Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775570
Funder
Australian Research Council
Funding Amount
$570,000.00
Summary
Purchase of a high resolution organic mass spectrometer. The diverse research supported by the new instrument is expected to encompass a wide range of beneficial outcomes in the areas of health, plant genetics and breeding, horticulture, chemistry and novel analytical technologies. Genetic studies will lead to improved plant crops and are expected to contribute to new treatments for multiple scleroris and diabetes. Investigations in organic and organometallic chemistry will lead to the productio ....Purchase of a high resolution organic mass spectrometer. The diverse research supported by the new instrument is expected to encompass a wide range of beneficial outcomes in the areas of health, plant genetics and breeding, horticulture, chemistry and novel analytical technologies. Genetic studies will lead to improved plant crops and are expected to contribute to new treatments for multiple scleroris and diabetes. Investigations in organic and organometallic chemistry will lead to the production of better materials, more efficient catalysts and novel drugs. This instrument will provide infrastructure essential to enabling researchers to maintain internationally competitive profiles in these areas.Read moreRead less
A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on th ....A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on the role this protein family may play in all animals. The findings are expected to provide key insights into the modification of growth factor activity, which is often dysregulated in human cancers and growth disorders, and may enable the design of new strategies for interfering with insect development for pest control.Read moreRead less
Ultra-high-throughput genotyping of Eucalyptus trees: Development and application of diversity array technology for genomic studies. A major international eucalypt genomic project is underway. Australia needs to take part because the Australian public would expect Australia to be at the forefront of research on one of its national symbols. Eucalypts are critically important to biodiversity and commercial forestry. The development of the proposed generic eucalypt DArT chip will help keep Australi ....Ultra-high-throughput genotyping of Eucalyptus trees: Development and application of diversity array technology for genomic studies. A major international eucalypt genomic project is underway. Australia needs to take part because the Australian public would expect Australia to be at the forefront of research on one of its national symbols. Eucalypts are critically important to biodiversity and commercial forestry. The development of the proposed generic eucalypt DArT chip will help keep Australia at the forefront of genetic and genomic research in eucalypts and help develop our biotechnology industry. Such research is essential for future forest tree breeding. Furthermore, eucalypt forests are one of our most important natural assets and their continual preservation requires that we develop better knowledge of their natural genetic variation and development.Read moreRead less
Transitions between modes of sex-determination in a changing world. Sex-determination controls the largest variation within animals—the division into males and females. While the different systems of sex-determination—involving genetic or environmental control—are fairly well understood, transitions between these systems remain enigmatic in evolutionary biology. This project aims to address this gap by revealing the molecular change required to transition between systems, using one of only two k ....Transitions between modes of sex-determination in a changing world. Sex-determination controls the largest variation within animals—the division into males and females. While the different systems of sex-determination—involving genetic or environmental control—are fairly well understood, transitions between these systems remain enigmatic in evolutionary biology. This project aims to address this gap by revealing the molecular change required to transition between systems, using one of only two known lizard species exhibiting both genetic and temperature control of sex. This knowledge will have important implications for species conservation, facilitating predictions of highly biased sex ratios under climate change, plus potential commercial applications for species where production of one sex is favoured.Read moreRead less
Redefining the molecular mechanism underlying crustacean metamorphosis. This project uses the astonishing lifecycle of lobster larvae to better define the pathways and discover the key genes that regulate crustacean metamorphosis. Where, when, why and how metamorphosis occurs in crustaceans are important factors affecting fisheries recruitment and aquaculture production. The project suggests that the current accepted paradigm for the molecular control of metamorphosis does not apply to lobsters ....Redefining the molecular mechanism underlying crustacean metamorphosis. This project uses the astonishing lifecycle of lobster larvae to better define the pathways and discover the key genes that regulate crustacean metamorphosis. Where, when, why and how metamorphosis occurs in crustaceans are important factors affecting fisheries recruitment and aquaculture production. The project suggests that the current accepted paradigm for the molecular control of metamorphosis does not apply to lobsters and possibly other crustaceans where larval metamorphosis and the juvenile transformation are uncoupled. Using a unique supply of cultured lobsters and advanced molecular techniques, the project aims to develop tools to trigger and synchronise metamorphosis for use in aquaculture and invasive species management.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100080
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Acquisition of an advanced Fluorescence-Activated Cell Sorter for Tasmania. Tasmania has immediate need for contemporary flow cytometry infrastructure to maintain world-class research for local and global benefit. This project aims to establish next generation, single cell sorting capability to study the impact of ageing and environmental stressors on human, animal and plant biology. Outcomes of this project include: 1) multi-disciplinary expansion across the areas of neuroscience, ecology, evol ....Acquisition of an advanced Fluorescence-Activated Cell Sorter for Tasmania. Tasmania has immediate need for contemporary flow cytometry infrastructure to maintain world-class research for local and global benefit. This project aims to establish next generation, single cell sorting capability to study the impact of ageing and environmental stressors on human, animal and plant biology. Outcomes of this project include: 1) multi-disciplinary expansion across the areas of neuroscience, ecology, evolutionary biology, oceanography, epi/genomics and immunology, 2) ability to develop innovative assays and vaccines, and 3) increase the scale of national and international collaborations. This project will provide direct benefit through our contribution of new knowledge, commercial uptake and impact on policy.Read moreRead less
Turning back the clock on brain cell aging. This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable ....Turning back the clock on brain cell aging. This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable cognitive decline that occurs in healthy aging and why some populations age less successfully than others do. Better understanding of the impact of environmental change on the biology of aging has potential community benefits.Read moreRead less