Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Platinum deposit genesis: A new way of thinking. Platinum is becoming increasingly crucial to the high technology sector, and is used particularly in catalytic converters and fuel cells, which serve to minimise or eliminate car exhaust pollution. Greatly expanded resources of this precious metal are needed to help society's transition to a low carbon dioxide (CO2) lifestyle. This project will combine high temperature-pressure experiments with geological field research to greatly improve our unde ....Platinum deposit genesis: A new way of thinking. Platinum is becoming increasingly crucial to the high technology sector, and is used particularly in catalytic converters and fuel cells, which serve to minimise or eliminate car exhaust pollution. Greatly expanded resources of this precious metal are needed to help society's transition to a low carbon dioxide (CO2) lifestyle. This project will combine high temperature-pressure experiments with geological field research to greatly improve our understanding of how platinum ore deposits form and thus where to find them. The outcomes of this project will change mineral exploration strategies in Australia and around the world, and facilitate our progression to a cleaner, greener future.Read moreRead less
Plate kinematics to plate dynamics: understanding plate boundary processes at the global scale. This proposal aims to create geodynamic models which can be used a basis for a new, smart resource exploration and extraction industry which uses simulation to help characterize regions where traditional geophysical imaging alone is not able to penetrate. It provides essential scientific underpinnings for
The Australian Computational Earth System Simulator Major National Research Facility (ACcESS).
NUMERICAL MODELS OF PLATE TECTONICS, MANTLE CONVECTION AND SLAB DYNAMICS WITH EVOLVING FAULTS. We plan to develop a method for simulating large-scale
geological structures with a much improved treatment
of tectonic faults in 3D.
Current computer models have sharp geological faults at plate
boundaries represented by broad, blurred zones. New techniques
for modeling cracks in engineering structures will be scaled up to
the whole Earth.
This will help us to understand how the Earth's p ....NUMERICAL MODELS OF PLATE TECTONICS, MANTLE CONVECTION AND SLAB DYNAMICS WITH EVOLVING FAULTS. We plan to develop a method for simulating large-scale
geological structures with a much improved treatment
of tectonic faults in 3D.
Current computer models have sharp geological faults at plate
boundaries represented by broad, blurred zones. New techniques
for modeling cracks in engineering structures will be scaled up to
the whole Earth.
This will help us to understand how the Earth's plates move and
interact now and in the past and how the structure of the continents
arose.
Not only is this intrinsically interesting, it
will also be of immediate practical benefit to geological modelers.Read moreRead less
Volatile recycling at the crust-mantle interface: Evidence from halogens and noble gases in deep-crustal fluids. 1) The technique proposed for this study is of proven interest to the mineral exploration industry. This project will: i) increase knowledge of the deep-crustal fluids often implicated in giant hydrothermal ore deposits; and ii) develop laser ablation, which will increase the techniques applicability to Australia's oldest ore deposits. These outcomes will further benefit the mineral e ....Volatile recycling at the crust-mantle interface: Evidence from halogens and noble gases in deep-crustal fluids. 1) The technique proposed for this study is of proven interest to the mineral exploration industry. This project will: i) increase knowledge of the deep-crustal fluids often implicated in giant hydrothermal ore deposits; and ii) develop laser ablation, which will increase the techniques applicability to Australia's oldest ore deposits. These outcomes will further benefit the mineral exploration industry.
2) The experimental data can be applied to testing the long-term storage of CO2 by geo-sequestration.
3) The proposed research is extremely topical and will be presented at international conferences and in high impact journals raising the profile of Australian science. Read moreRead less
Thick-skin continental deformation and the rheology of faulted continental lithosphere. We plan to study the way in which major, long-lived faults influence the large-scale deformation of continental lithosphere in response to plate and mantle derived stresses. We will develop realistic computer models of networks of faults embedded in the crust to examine the way large faults (e.g. the San Andreas fault in California) interact with the deep crust and shallow mantle and the way they interact w ....Thick-skin continental deformation and the rheology of faulted continental lithosphere. We plan to study the way in which major, long-lived faults influence the large-scale deformation of continental lithosphere in response to plate and mantle derived stresses. We will develop realistic computer models of networks of faults embedded in the crust to examine the way large faults (e.g. the San Andreas fault in California) interact with the deep crust and shallow mantle and the way they interact with each other. No one previous model has been able to incorporate all the important dynamics. The work will be used by structural geologists, planetary scientists and be a valuable tool in mineral exploration.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989123
Funder
Australian Research Council
Funding Amount
$575,000.00
Summary
Spark Plasma Sintering (SPS) Facility for Advanced Materials Processing. The establishment of the first Spark Plasma Sintering (SPS) facility would significantly enhance Australia's capacity in manufacturing of advanced materials, especially the more sophisticated and specialized materials, which is a National Research Priority. This facility will benefit a large number of researchers and projects in Australia's premier research organisations and will also meet the needs of organisations outside ....Spark Plasma Sintering (SPS) Facility for Advanced Materials Processing. The establishment of the first Spark Plasma Sintering (SPS) facility would significantly enhance Australia's capacity in manufacturing of advanced materials, especially the more sophisticated and specialized materials, which is a National Research Priority. This facility will benefit a large number of researchers and projects in Australia's premier research organisations and will also meet the needs of organisations outside the consortium. It will allow Australian researchers to remain at the leading edge of research and enhance collaborations in advanced materials nationwide. The successful outcomes of these activities will underpin the advancement in many areas of research and technology developments in the country.Read moreRead less
Epigenetic Programming Of Immune Development In Utero: Role Of The Maternal Environment In The Allergy Epidemic
Funder
National Health and Medical Research Council
Funding Amount
$764,463.00
Summary
This study will provide new insights into the development of allergic disease. Specifically, we will explore the hypothesis that allergic disease and other disorders or immune dysregulation occur as a result of gene-environmental interactions in early life, and that these events begin in pregnancy when the developing fetus is still developing and most susceptible to these effects.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less