Diseases of the 21st century are complex with environmental and genetic causes. At the interface of these is Epigenetics - factors not specified by DNA sequence that control genes. Recent data show much of the risk associated with disease is set early in life, even during the time in the womb. The MCRI CDDE laboratory has assembled teams of researchers of diverse expertise investigating epigenetics of human development and complex disease to hopefully prevent or reverse them early in life.
A National Population-based Study Of Rheumatic Heart Disease In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$877,826.00
Summary
Whilst overall a rare disease, Indigenous peoples have disproportionately high rates of rheumatic heart disease (RHD). This study explores the prevalence and distribution of RHD in pregnancy in Australia and New Zealand. It details current management, diagnostic and referral process and risk factors. Key attributes of culturally safe models of care for RHD in pregnancy are explored, particularly as they relate to Indigenous women. Findings will inform policy, guidelines and education resources.
Early Nutrition, Epigenetics And Developmental Outcomes In Children.
Funder
National Health and Medical Research Council
Funding Amount
$550,093.00
Summary
Increasing evidence demonstrates that early nutrition, including in pregnancy, has long lasting programming effects on later health of children. Evidence implicates epigenetics (literally ‘above DNA’) in mediating these effects. The most convincing data exists for obesity and related disorders such as metabolic syndrome, diabetes, and heart disease. The focus of this project is on understanding how ‘epigenetic’ mechanisms are influencing the way our genes function to cause these disorders.
Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Epigenetic Programming Of Immune Development In Utero: Role Of The Maternal Environment In The Allergy Epidemic
Funder
National Health and Medical Research Council
Funding Amount
$764,463.00
Summary
This study will provide new insights into the development of allergic disease. Specifically, we will explore the hypothesis that allergic disease and other disorders or immune dysregulation occur as a result of gene-environmental interactions in early life, and that these events begin in pregnancy when the developing fetus is still developing and most susceptible to these effects.
Special Research Initiatives - Grant ID: SR0354823
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
National network for the study of cognitive processes and treatment across the phases of schizophrenia. Schizophrenia is associated with great costs to the community and individual. Controlled studies have demonstrated Cognitive Behaviour Therapy (CBT) is efficacious in treating symptoms of schizophrenia. Studies of cognitive processes have also advanced understanding of psychotic phenomena. This initiative affords the opportunity to
1) Improve treatment efficacy by developing, testing and appl ....National network for the study of cognitive processes and treatment across the phases of schizophrenia. Schizophrenia is associated with great costs to the community and individual. Controlled studies have demonstrated Cognitive Behaviour Therapy (CBT) is efficacious in treating symptoms of schizophrenia. Studies of cognitive processes have also advanced understanding of psychotic phenomena. This initiative affords the opportunity to
1) Improve treatment efficacy by developing, testing and applying theoretically-driven models of psychotic symptoms.
2) Disseminate the findings of research on CBT for psychotic disorders in clinical settings by (a) training the work-force, and (b) facilitating CBT delivery in routine practice.
3) Apply CBT in various settings with a variety of psychotic populations to test its effectiveness in routine clinical settings.
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Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring tha ....Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring that the evidence generated has contemporary policy relevance. The project expects to identify clear and actionable policy pathways to reduce child inequities in Australia, which can benefit decision makers by helping them to direct limited public funds towards intervention opportunities that will have the greatest impact.Read moreRead less
Internet technologies, health informatics and statistical methods, and new delivery platforms in call centres. Although depression is the major cause of health disability, 60% of Australians with depression do not receive professional help. There are few systems for delivering health information and resilience skills to members of the community. This project aims to develop a workable system to reduce unmet need. It will provide a model of information delivery applicable to other areas of the ....Internet technologies, health informatics and statistical methods, and new delivery platforms in call centres. Although depression is the major cause of health disability, 60% of Australians with depression do not receive professional help. There are few systems for delivering health information and resilience skills to members of the community. This project aims to develop a workable system to reduce unmet need. It will provide a model of information delivery applicable to other areas of the health industry, particularly those involving chronic disease. It has applicability to education and other sectors which involve the delivery of information to the public. Because e-health is an emerging field, the project also has the capacity to build expertise in an area which is under-resourced. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100637
Funder
Australian Research Council
Funding Amount
$322,534.00
Summary
Finding the Path: Service access and navigation for serious mental illness. This project aims to inform health system change to ensure people with serious mental illness can access quality services. While improved access to quality mental health services has been a key target in Australian health policy for over 20 years, people with mental illness continue to report problems accessing and navigating the complex service system. The project aims to study consumers' mental health service experienc ....Finding the Path: Service access and navigation for serious mental illness. This project aims to inform health system change to ensure people with serious mental illness can access quality services. While improved access to quality mental health services has been a key target in Australian health policy for over 20 years, people with mental illness continue to report problems accessing and navigating the complex service system. The project aims to study consumers' mental health service experiences using policy, qualitative, quantitative and geographic analysis to identify systemic problems. Mental health consumers and service providers will be actively involved in developing final policy recommendations to ensure system change reflects their knowledge.Read moreRead less