Making Human T- And B-lymphocytes For Immunotherapy And Antibody Production
Funder
National Health and Medical Research Council
Funding Amount
$795,880.00
Summary
Lymphocytes are white blood cells that are involved in producing antibodies, killing defective cells, or killing cells infected with viruses. In recent years, researchers have found ways to harness lymphocytes to develop medicines for treating a variety of different cancers. In this project, we will establish methods to make human lymphocytes in the laboratory from stem cells, paving the way for the broader application of this cell type to new therapies.
A Suite Of Engineered Human Pluripotent Stem Cell Lines To Facilitate The Generation Of Hematopoietic Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$881,221.00
Summary
Our goal is to develop tools that address major bottlenecks that have prevented the generation of blood forming stem cells in culture for therapeutic use. We will generate human embryonic stem cell reporter lines that can be used to monitor key milestones in blood stem cell development. These lines will serve as tools to identify growth conditions to improve the differentiation of pluripotent stem cells to functional blood stem cells.
Electronically Conducting Nanofibres and Assemblies. With the use of new techniques that have just emerged in the last two years and are receiving rapidly growing interest throughout the world, this project will bring to Australia a new nanofabrication platform for making a variety of complex nanostructures. Fundamental researches on these complex nanostructures will greatly advance nanoscience. New nanotechnologies will be developed to address some world-wide challenging problems, e.g. energy ....Electronically Conducting Nanofibres and Assemblies. With the use of new techniques that have just emerged in the last two years and are receiving rapidly growing interest throughout the world, this project will bring to Australia a new nanofabrication platform for making a variety of complex nanostructures. Fundamental researches on these complex nanostructures will greatly advance nanoscience. New nanotechnologies will be developed to address some world-wide challenging problems, e.g. energy conversion and storage, chemical/biological sensing and other micro- and nanoelectronic devices. This project will bring both breakthrough science and frontier technologies for building and transforming Australian industries and help place Australia at the forefront of nanotechnology. Read moreRead less
The characterization and pocessing of Australian grown hemp fibres. This project will, for the first time, systematically examine the characteristics and processing behaviour of Australian grown hemp fibres. The hemp industry is an emerging new industry in rural Australia. This research will tackle a number of complex problems concerning characterization, degumming, and processing of Australian grown hemp, and will engineer the finest and softest yarns as well as industrial products from this he ....The characterization and pocessing of Australian grown hemp fibres. This project will, for the first time, systematically examine the characteristics and processing behaviour of Australian grown hemp fibres. The hemp industry is an emerging new industry in rural Australia. This research will tackle a number of complex problems concerning characterization, degumming, and processing of Australian grown hemp, and will engineer the finest and softest yarns as well as industrial products from this hemp. This will position the local hemp industry as well fibre processing industry in a very strong position to meet the growing demand world wide on this "green" fibre.Read moreRead less
Understanding the Behavior of Single-Walled Carbon Nanotubes in Liquids. The imminent manufacture of Single Walled Carbon Nanotubes (SWNTs) at prices comparable to those of high-performance polymers such as Kevlar, will open up potential applications of SWNTs as high-performance fibres and coatings. A major challenge is the development of scalable processes for producing large objects made of SWNTs. This project, in collaboration with researchers at Rice and Stanford Universities, aims to unders ....Understanding the Behavior of Single-Walled Carbon Nanotubes in Liquids. The imminent manufacture of Single Walled Carbon Nanotubes (SWNTs) at prices comparable to those of high-performance polymers such as Kevlar, will open up potential applications of SWNTs as high-performance fibres and coatings. A major challenge is the development of scalable processes for producing large objects made of SWNTs. This project, in collaboration with researchers at Rice and Stanford Universities, aims to understand the principles that underlie the successful liquid state processing of SWNTs. The novel strategies that arise will cement Australia's position as a leading country for research in nanotechnology, and place it at the forefront of this field, with great potential for economic advantage.Read moreRead less
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less
New hybrid fibres incorporating nano protein materials. This project aims to develop new cellulose fibres incorporating nano protein materials extracted from animal fibres such as wool. The structure and property of the new hybrid fibres will be studied. Combining cellulose and protein materials within a single fibre is a new and original concept. This will lead to the production of new fibres with enhanced attributes and add significant value to the multi-billion dollar animal fibre industry in ....New hybrid fibres incorporating nano protein materials. This project aims to develop new cellulose fibres incorporating nano protein materials extracted from animal fibres such as wool. The structure and property of the new hybrid fibres will be studied. Combining cellulose and protein materials within a single fibre is a new and original concept. This will lead to the production of new fibres with enhanced attributes and add significant value to the multi-billion dollar animal fibre industry in Australia. It will also benefit the collaborating country as the major consumer of animal fibres imported from AustraliaRead moreRead less
An Integrated Systems Biology Approach For The Development Of New Therapeutic Strategies For The Treatment Of High Grade Glioma
Funder
National Health and Medical Research Council
Funding Amount
$696,404.00
Summary
Glioma, the most common adult brain cancer, is incurable. Recent advances now allow us to grow glioma cells directly from patients in the laboratory in a way that preserves the features of the original tumor. In this proposal we will systematically analyze such cells using state-of-the-art technologies to identify new processes important to glioma, which in turn should facilitate the identification of innovative therapeutic approaches.
Resilient Remote Environment Emulation for Human-to-Machine Communication. Human-to-machine haptic communication allow humans to immersively interact with remotely-located robots/machines. Current networks cannot support its technical demands, thereby limiting the achievable human-machine distance. This project aims to develop cloudlet intelligence together with a programmable resilient network to realise reliable remote environment emulation, a concept where the physical environment at the remo ....Resilient Remote Environment Emulation for Human-to-Machine Communication. Human-to-machine haptic communication allow humans to immersively interact with remotely-located robots/machines. Current networks cannot support its technical demands, thereby limiting the achievable human-machine distance. This project aims to develop cloudlet intelligence together with a programmable resilient network to realise reliable remote environment emulation, a concept where the physical environment at the remote machine is emulated close to the human. A key outcome will be the first reliable remote environment emulation platform that achieves vast human-machine distances on current networks. Enabling immersive human-machine experience will significantly benefit many sectors, from education through to industrial manufacturing.Read moreRead less
Formation and characterisation of continuous electrospun nanofibre yarns. Australia historically has a strong fibre and textile industry that can be augmented by embracing emerging nanotechnology. The proposed research will develop a technology that can greatly improve the productivity of nanofibres. These fibres can then be spun into continuous yarns and other form of textile products. The nanostructured products offer exceptional functions for biomedical and environmental applications. This ne ....Formation and characterisation of continuous electrospun nanofibre yarns. Australia historically has a strong fibre and textile industry that can be augmented by embracing emerging nanotechnology. The proposed research will develop a technology that can greatly improve the productivity of nanofibres. These fibres can then be spun into continuous yarns and other form of textile products. The nanostructured products offer exceptional functions for biomedical and environmental applications. This new technology has the potential to transform the Australian textile technology and fibre processing industry. Read moreRead less