First Aid For Burns: The Use Of Ice Water And Ice?
Funder
National Health and Medical Research Council
Funding Amount
$209,668.00
Summary
Millions of people worldwide receive burn injuries every year and last year the Royal Children's Hospital in Brisbane alone treated more than 500 children with new burn injuries. Many of these children with burn injuries will heal burn wounds with unsightly scars and impaired skin function. Cooling burns as first aid has been used since ancient time and is proved to be the most effective way to reduce skin temperature, lessen pain, minimize the depth of injury, and ultimately improve wound heali ....Millions of people worldwide receive burn injuries every year and last year the Royal Children's Hospital in Brisbane alone treated more than 500 children with new burn injuries. Many of these children with burn injuries will heal burn wounds with unsightly scars and impaired skin function. Cooling burns as first aid has been used since ancient time and is proved to be the most effective way to reduce skin temperature, lessen pain, minimize the depth of injury, and ultimately improve wound healing outcome. However, despite the evidence that cooling burns using ice water <4 C may be beneficial to burns, current first aid recommend to only use cold water 8-25 C and the use of ice-ice water is strongly discouraged for fear of the potential to cause hypothermia and deepen the existing burn injury. In this application we will examine the effect of ice-ice water 2 C on wound healing outcome compared to 15 C water as first aid, in an in vivo model. The wound healing will be clinically assessed by experienced clinicians weekly for six weeks, and then will also be assessed histologically and mechanically at week six. We will also determine the optimal cooling temperature and duration for injured tissue in burn wounds to recover and the conduction of cold through skin. With the coming new knowledge we wish to design an optimal cooling burn treatment which will maximize the beneficial of cooling to the burns but avoid adverse effect of excessive cooling. The success of this project will advance our knowledge on first aid treatment or burn cooling treatment and also wound healing process. It will enable us to offer better first aid treatment which may lead to wound healing with less scars, otherwise can not achieved by other current available treatments. The better healing of burn wounds will significantly improve burn patients' lives, particularly children with burn injuries. It will also release the burden on much needed health funds.Read moreRead less
Does Antipsychotic Dose Reduction Lead To Better Functional Recovery In First Episode Psychosis: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,371,552.00
Summary
Can a person with a first episode of psychosis, once remitted, reduce their dosage of medication and still achieve better outcomes in functioning, physical health and brain volume, than if they had stayed on traditional maintenance doses of medication? This study will examine if using a dose reduction strategy in conjunction with an evidence based suite of psychosocial interventions leads to better social and vocational recovery and improved physical health and brain volume.
The Efficacy Of N-acetyl Cysteine As An Adjunctive Treatment For First Episode Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$2,143,069.00
Summary
First episode psychosis may foreshadow devastating, chronic illness. Psychosis follows a staged, progressive pathway. There is evidence to suggest illness progression can be diminished and perhaps even averted if appropriate treatments are given at the early stages of illness. This project will test if N-acetycysteine (NAC) administered to young people who have experienced a first episode of psychosis can help prevent this early psychotic experience from developing into a chronic disorder.
Predicting Language Skills From Early Auditory Speech Discrimination In Infants With Hearing Loss: Implications For Early Management And Intervention
Funder
National Health and Medical Research Council
Funding Amount
$706,113.00
Summary
Now that newborn hearing checks are available, hearing loss can be picked up soon after birth and hearing aids are fitted shortly after. Although procedures exist for checking that the devices make sounds audible, there is no way to evaluate their effectiveness for supporting a child’s auditory discrimination. This study aims to 1) develop new clinical tools for assessing infants’ auditory discrimination, and 2) determine whether early discrimination predicts spoken language at 3 years of age.
GEM Study: General And Emotional Cognition In First Onset Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$385,659.00
Summary
Schizophrenia is a devastating mental illness that disrupts cognitive and emotional function. We assessed which cognitive and emotional impairments characterize the first onset of schizophrenia and identified their brain basis in neural circuits. We also assessed whether these impairments predict outcomes over time.