New Membrane Chips For Protein Interaction Analysis. This proposal is based on a strategic partnership between Monash University and Farfield Sensors. We will create a series of new biosensors that will be used to establish a new approach to the structural analysis of membrane protein function. In particular, this technology may lead to the identification of new proteins and drug targets for therapeutic development. The long-term outcome would be the development of improved therapeutics which wo ....New Membrane Chips For Protein Interaction Analysis. This proposal is based on a strategic partnership between Monash University and Farfield Sensors. We will create a series of new biosensors that will be used to establish a new approach to the structural analysis of membrane protein function. In particular, this technology may lead to the identification of new proteins and drug targets for therapeutic development. The long-term outcome would be the development of improved therapeutics which would be coupled to potential economic returns when further commercialisation is achieved. Read moreRead less
Molecular-genetic organization and evolution of dinoflagellate mitochondria. Dinoflagellates are unicellular organisms that are important parts of the biota as significant primary producers of the oceans. Certain dinoflagellates form essential symbionts of reef-forming corals and loss of the symbiont causes coral bleaching and death, a phenomenon linked to global warming. Dinoflagellate blooms are also notorious for causing fish kills and human illnesses such as paralytic shellfish poisoning. My ....Molecular-genetic organization and evolution of dinoflagellate mitochondria. Dinoflagellates are unicellular organisms that are important parts of the biota as significant primary producers of the oceans. Certain dinoflagellates form essential symbionts of reef-forming corals and loss of the symbiont causes coral bleaching and death, a phenomenon linked to global warming. Dinoflagellate blooms are also notorious for causing fish kills and human illnesses such as paralytic shellfish poisoning. My studies of the mitochondrion will address a major aspect of the biology of this poorly understood group. Mitochondrial function is often a target for drugs and other controlling agents, and therefore these studies could offer scope to better interpret and manage dinoflagellates in our environment.Read moreRead less
The cost of a meal: life-history consequences of foraging mode in fur seals and sea lions. Australia's two fur seal species are currently experiencing population increases throughout their range as they recover from the over-exploitation of the commercial sealing era (18-19th centuries) whereas the Australian sea lion population is decreasing (or stable but low) throughout its range and is considered vulnerable. Understanding the mechanisms which determine foraging efficiency in fur seals and s ....The cost of a meal: life-history consequences of foraging mode in fur seals and sea lions. Australia's two fur seal species are currently experiencing population increases throughout their range as they recover from the over-exploitation of the commercial sealing era (18-19th centuries) whereas the Australian sea lion population is decreasing (or stable but low) throughout its range and is considered vulnerable. Understanding the mechanisms which determine foraging efficiency in fur seals and sea lions will have implications for the management of these species, which are likely to experience increasing interactions with fisheries activities. The results of this research will assist in the development of policies to ensure the environmentally sustainable use of marine resources. Read moreRead less
Assembly and function of arabinogalactan-proteins: a class of proteoglycans involved in plant growth and development. We aim to define the mechanisms by which a family of cell surface proteoglycans, the arabinogalactan-proteins (AGPs), are assembled and contribute to the regulation of plant growth and development using Arabidopsis, a model system amenable to a functional genomics strategy. This will be achieved through the application of bioinformatics for gene discovery and molecular, biochemi ....Assembly and function of arabinogalactan-proteins: a class of proteoglycans involved in plant growth and development. We aim to define the mechanisms by which a family of cell surface proteoglycans, the arabinogalactan-proteins (AGPs), are assembled and contribute to the regulation of plant growth and development using Arabidopsis, a model system amenable to a functional genomics strategy. This will be achieved through the application of bioinformatics for gene discovery and molecular, biochemical and genetics approaches to define gene function. Understanding mechanisms that control plant growth and development will ultimately impact on industries (agriculture, horticulture and forestry) vital to Australia's prosperity.Read moreRead less
Assembly and function of arabinogalactan-proteins: a class of proteoglycans involved in plant growth and development. Achievements of the Objectives will specifically address National Research Priority 3 by developing breakthrough science and utilising frontier technologies with application to Australia's agri-biotechnology industries. In addition to contributing to world class research outcomes, we will train highly skilled graduates and postdoctoral fellows in functional genomics technologies, ....Assembly and function of arabinogalactan-proteins: a class of proteoglycans involved in plant growth and development. Achievements of the Objectives will specifically address National Research Priority 3 by developing breakthrough science and utilising frontier technologies with application to Australia's agri-biotechnology industries. In addition to contributing to world class research outcomes, we will train highly skilled graduates and postdoctoral fellows in functional genomics technologies, thereby contributing to the "knowledge nation".Read moreRead less
How does allocation to each sex evolve in hermaphrodites? New insight from the sea. Understanding the ability of hermaphroditic animals to adapt their sex allocation to suit environmental conditions will pave the way for integration between pure and applied research. Such understanding can provide stakeholders across a range of disciplines (natural resource management, aquaculture, conservation) with key information about genetic and environmental influences on the reproduction of many species o ....How does allocation to each sex evolve in hermaphrodites? New insight from the sea. Understanding the ability of hermaphroditic animals to adapt their sex allocation to suit environmental conditions will pave the way for integration between pure and applied research. Such understanding can provide stakeholders across a range of disciplines (natural resource management, aquaculture, conservation) with key information about genetic and environmental influences on the reproduction of many species of significant ecological, economic and social value with this mating system. This research will yield knowledge at the very forefront of evolutionary ecology, enhancing Australia's reputation for research excellence in this field, and further benefit Australian science through the training of young scientists.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560722
Funder
Australian Research Council
Funding Amount
$512,744.00
Summary
High-speed Ultracentrifuge Facility with Sensitive Scanning Optics for the Analysis of Interacting Biomolecules. This request is for a high-speed analytical ultracentrifuge equipped with sensitive absorbance, fluorescence, and interference scanning optics. The equipment, the first of its kind in Australia, would establish a world-class facility for analysing the size, shape, and stability of macromolecular complexes and their interactions in solution. This new facility will enable high through ....High-speed Ultracentrifuge Facility with Sensitive Scanning Optics for the Analysis of Interacting Biomolecules. This request is for a high-speed analytical ultracentrifuge equipped with sensitive absorbance, fluorescence, and interference scanning optics. The equipment, the first of its kind in Australia, would establish a world-class facility for analysing the size, shape, and stability of macromolecular complexes and their interactions in solution. This new facility will enable high through-put screening of small molecules with potential as new drugs. This core platform technology will cover the range of needs from basic research through to commercialization of discovery. The equipment will support existing high quality research projects in biotechnology and provide new opportunities for post-graduate training and international collaboration.Read moreRead less
Valuations and Business Models for Biotechnology Companies. The primary aim of this project is to reduce the risk involved in investment in biotechnology companies by developing a model that will aid in a more accurate assessment of their value. This project will also develop commercialisation pathways incorporating valuation modeling techniques that will maximise the commercial potential of the intellectual capital portfolios held by biotechnology companies. By developing new models that accoun ....Valuations and Business Models for Biotechnology Companies. The primary aim of this project is to reduce the risk involved in investment in biotechnology companies by developing a model that will aid in a more accurate assessment of their value. This project will also develop commercialisation pathways incorporating valuation modeling techniques that will maximise the commercial potential of the intellectual capital portfolios held by biotechnology companies. By developing new models that account for the specific variables of the biotechnology industry, this project will contribute new knowledge and advance development of valuation models applicable to other knowledge-based industries which share characteristics such as intangible assets, high risk, complexity and uncertainty.Read moreRead less