A coupled finite volume method for viscoelastic flow problems on highly-skewed unstructured meshes: a computational rheology revolution. Commercial tools are unavailable for 21st century industry to analyse complex flow processes involving viscoelastic materials. Using fabrication of microstructured polymer optical fibre as a key case study, a coupled finite volume methodology holds the key for the next generation of computational rheology simulators.
A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools ....A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools and the imaging platform will have applications for researchers wishing to visualise small and rapid molecular events in four dimensions (length, width, height and across time) under fluid shear stress, which is applicable across a range of industries. The project expects to deliver the next generation of intravital microscopes that can visualise and quantify events in a challenging flow environment.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Seeing is believing: Microscopy-capable single-molecule bioelectronics. This project aims to create new biophysical tools for single-molecule sensing by advancing the state-of-the-art in nanoscale bioelectronic devices. The goal is to generate novel bioelectronic devices optimised for fabrication on microscope coverslip (170 micron glass) for compatibility with new low-cost platforms for advanced biological microscopy. Expected outcomes include the first organic electrochemical transistors inter ....Seeing is believing: Microscopy-capable single-molecule bioelectronics. This project aims to create new biophysical tools for single-molecule sensing by advancing the state-of-the-art in nanoscale bioelectronic devices. The goal is to generate novel bioelectronic devices optimised for fabrication on microscope coverslip (170 micron glass) for compatibility with new low-cost platforms for advanced biological microscopy. Expected outcomes include the first organic electrochemical transistors interfaced to constrained area lipid bilayers for studying membrane proteins at single-molecule level and nanoscale transistors for electrostatically detecting motile microtubules in in-vitro molecular motor assays for biocomputation. The intended benefit is innovation in capabilities and manufacturing of bioelectronics.Read moreRead less
Developing novel aerosol inhalers for pulmonary drug delivery from the fundamental understanding of powder dispersion mechanisms. The project seeks to understand how powder aerosol inhalers can be significantly improved. The outcome will provide therapeutic benefits to the Australian community for better treatment of respiratory diseases and facilitate environmentally friendly technology since these inhalers do not require any harmful organic solvents to operate.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100073
Funder
Australian Research Council
Funding Amount
$174,627.00
Summary
Australian Contribution to CERN Large Hadron Collider Experiment Upgrade. Australian contribution to CERN large hadron collider experiment upgrade: The discovery of the Higgs Boson with the ATLAS experiment at the CERN laboratory's large hadron collider, has been a highlight for Australian science. Scientists will build upon the foundation of the Higgs discovery to further probe the nature of matter at the finest scales and highest energies. Detailed measurements of the Higgs characteristics wil ....Australian Contribution to CERN Large Hadron Collider Experiment Upgrade. Australian contribution to CERN large hadron collider experiment upgrade: The discovery of the Higgs Boson with the ATLAS experiment at the CERN laboratory's large hadron collider, has been a highlight for Australian science. Scientists will build upon the foundation of the Higgs discovery to further probe the nature of matter at the finest scales and highest energies. Detailed measurements of the Higgs characteristics will determine if it is as predicted by the Standard Model or whether it admits a variation, signalling new physics. The upgrade in this project will provide for such detailed measurements. It will also allow sensitive probes of new physics, searching for new particles or unexpected interactions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100042
Funder
Australian Research Council
Funding Amount
$621,834.00
Summary
Australian dark matter detector for high mass axions. This project aims to provide the necessary equipment to allow an Australian Dark Matter Axion Haloscope, with significantly increased sensitivity by providing a milliKelvin environment and a 14 T magnet to drive axion-to-photon conversions. Dark matter is a fundamental component of the universe yet the nature of its composition is still unknown. There is growing evidence that it is comprised of axions, a low energy, weakly interacting particl ....Australian dark matter detector for high mass axions. This project aims to provide the necessary equipment to allow an Australian Dark Matter Axion Haloscope, with significantly increased sensitivity by providing a milliKelvin environment and a 14 T magnet to drive axion-to-photon conversions. Dark matter is a fundamental component of the universe yet the nature of its composition is still unknown. There is growing evidence that it is comprised of axions, a low energy, weakly interacting particle. The precision measurement tools developed by this project will have the potential to contribute both to the economy, via commercialisation, and to national security, via future applications to radar, communication and the development of engineered quantum systems.Read moreRead less
Spatiotemporal dynamics and analysis of functional magnetic resonance imaging. Functional magnetic resonance imaging (fMRI) produces signals generated by brain activity in fine detail, but links between activity and images are poorly understood, posing a barrier to full use of the technology. Predictions from our new theory of such links will be made, tested experimentally and used to improve fMRI and discover new phenomena.
Metal dielectric microstructures: Tuneable metamaterials to medical devices. This project aims to demonstrate tuneable metamaterials fabricated economically and in volume. Tuneability is sought after and difficult to realise. This project will switch a metamaterial from metallic to dielectric behaviour, and dynamically vary the magnification of a hyperlens. To do this, it will create a micro/nanofabrication technology platform with potential widespread uses in high technology manufacturing. It e ....Metal dielectric microstructures: Tuneable metamaterials to medical devices. This project aims to demonstrate tuneable metamaterials fabricated economically and in volume. Tuneability is sought after and difficult to realise. This project will switch a metamaterial from metallic to dielectric behaviour, and dynamically vary the magnification of a hyperlens. To do this, it will create a micro/nanofabrication technology platform with potential widespread uses in high technology manufacturing. It expects to improve multi-modal neural interfaces for optogenetic research and implantable biomedical devices such as cochlear implants.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100037
Funder
Australian Research Council
Funding Amount
$223,039.00
Summary
Cryogenic quantum microscope facility. This project aims to establish a cryogenic, quantum microscope facility in Australia. Quantum sensing is a new field that harnesses the properties of individual quantum systems to realise new types of detection and imaging with unprecedented combination of sensitivity and spatial resolution. The potential innovations, applications and benefits to society are far reaching across the full spectrum of scientific and engineering activity, from the development o ....Cryogenic quantum microscope facility. This project aims to establish a cryogenic, quantum microscope facility in Australia. Quantum sensing is a new field that harnesses the properties of individual quantum systems to realise new types of detection and imaging with unprecedented combination of sensitivity and spatial resolution. The potential innovations, applications and benefits to society are far reaching across the full spectrum of scientific and engineering activity, from the development of atomic-scale imaging of protein structures for drug discovery, to the study of chemical, physical, and biological processes and materials for advanced technology and manufacturing.Read moreRead less