New techniques to detect fetal heart abnormalities. Australia’s national fetal death rate is 6.7 per one thousand births. In Australia’s Indigenous community it surges to 12.3 deaths per one thousand births. Early diagnosis (and management) of abnormal fetu.ses with cardiac defects will go a long way in reducing these numbers. The proposed technology will help set up easy-to-use systems for fetal cardiac abnormality screening and reduce fetal deaths and congenital heart disease burden in adult l ....New techniques to detect fetal heart abnormalities. Australia’s national fetal death rate is 6.7 per one thousand births. In Australia’s Indigenous community it surges to 12.3 deaths per one thousand births. Early diagnosis (and management) of abnormal fetu.ses with cardiac defects will go a long way in reducing these numbers. The proposed technology will help set up easy-to-use systems for fetal cardiac abnormality screening and reduce fetal deaths and congenital heart disease burden in adult life. This project will also provide domain trained researchers with cutting edge international academic and industry expertise.Read moreRead less
A role for Cited2, Transforming Growth Factor-beta and matrix metaloproteinases in trophoblast invasion and placenta formation. The placenta is essential for the growth and development of the fetus, and if it fails to form correctly during pregnancy, it can have dramatic effects that can result death in utero, or adult onset diseases. Our research aims to understand how one protein functions in placenta formation. We will also investigate how this protein works at the molecular level in a proces ....A role for Cited2, Transforming Growth Factor-beta and matrix metaloproteinases in trophoblast invasion and placenta formation. The placenta is essential for the growth and development of the fetus, and if it fails to form correctly during pregnancy, it can have dramatic effects that can result death in utero, or adult onset diseases. Our research aims to understand how one protein functions in placenta formation. We will also investigate how this protein works at the molecular level in a process that enables single cells to respond to molecules sent from a distance by other cells (TGF-beta signalling). This process is also very important for a host of other biological processes relevant to human health, including cancer.Read moreRead less
Development of a non-invasive diagnostic test of Embryo Viability. A successful outcome will:
. improve the cost effectiveness of assisted reproductive technologies resulting in reduced health care costs and allowing greater use of ART in animal production
. by greater cost-effectiveness, facilitate greater access to these advanced technologies in less well developed economies
. build the national capacity in development and validation of biotech diagnostics
. build collaborative relationsh ....Development of a non-invasive diagnostic test of Embryo Viability. A successful outcome will:
. improve the cost effectiveness of assisted reproductive technologies resulting in reduced health care costs and allowing greater use of ART in animal production
. by greater cost-effectiveness, facilitate greater access to these advanced technologies in less well developed economies
. build the national capacity in development and validation of biotech diagnostics
. build collaborative relationship between the CI, University of Sydney and a leading industry partner (Cook Australia)
. lead to significant new fundamental knowledge in embryology that will be of major International significance
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Screening and responding to domestic violence experienced by refugee women. We will adapt and test an evidence-based intervention to identify and address domestic violence with newly arrived refugee women, partnering with Settlement Services International, one of Australia’s largest providers of settlement programs. Domestic violence is the lead contributor to premature death among Australian women, and costs $22 b each year, with refugee women at heightened risk. This study will compare outcome ....Screening and responding to domestic violence experienced by refugee women. We will adapt and test an evidence-based intervention to identify and address domestic violence with newly arrived refugee women, partnering with Settlement Services International, one of Australia’s largest providers of settlement programs. Domestic violence is the lead contributor to premature death among Australian women, and costs $22 b each year, with refugee women at heightened risk. This study will compare outcomes for women who receive the intervention to controls and culturally sensitive, scaleable tested tools. This intervention should reduce the human and financial cost of domestic violence among refugee and other vulnerable migrant women, providing tools to settlement services to address this complex, hidden problem. Read moreRead less
Time of day, time awake and alcohol: the effects on fatigue and performance. The results of this study will clarify the effects of sleep deprivation and time of day on the experiences of fatigue and on performance. This information will have a direct impact on policy and practice relating to the management of fatigue. The results will have a direct impact on community safety, especially on the road and in the workplace. The study therefore has direct relevance for guidelines and regulations de ....Time of day, time awake and alcohol: the effects on fatigue and performance. The results of this study will clarify the effects of sleep deprivation and time of day on the experiences of fatigue and on performance. This information will have a direct impact on policy and practice relating to the management of fatigue. The results will have a direct impact on community safety, especially on the road and in the workplace. The study therefore has direct relevance for guidelines and regulations deveoped by bodies such as national and state road safety and workplace health and safety bodies.Read moreRead less
The impact of post-incident debriefing on psychological wellbeing and recall of events. First response emergency service personnel, such as fire fighters, police officers and paramedics provide an essential service, but as a result of their work are at increased risk of developing Post Traumatic Stress Disorder (PTSD). In an attempt to protect against PTSD many personnel are required to attend group debriefings following exposure to traumatic events. However, there is evidence that these group d ....The impact of post-incident debriefing on psychological wellbeing and recall of events. First response emergency service personnel, such as fire fighters, police officers and paramedics provide an essential service, but as a result of their work are at increased risk of developing Post Traumatic Stress Disorder (PTSD). In an attempt to protect against PTSD many personnel are required to attend group debriefings following exposure to traumatic events. However, there is evidence that these group debriefings may actually increase the risk of PTSD and also permanently distort the participants' memory for the events they witnessed. We will work with NSW Fire Brigade to develop an effective PTSD intervention for emergency service personnel which also preserves the integrity of the participants' memory for critical events.Read moreRead less
Neurosteroid Mediated Protection After Birth: Approaches For Maximising Protective Steroid Levels In The Neonatal Brain
Funder
National Health and Medical Research Council
Funding Amount
$450,703.00
Summary
Complications during pregnancy, birth asphyxia or premature birth can lead to neurological impairment in the newborn. Despite excellent neonatal care many of these babies go on to have serious handicaps. Neurosteroids are a group of steroids that regulate brain activity. These steroids protect brain cells from damage caused by an inadequate supply of oxygen by suppressing toxicity caused by excessive activity. We have shown that the levels of these protective steroids are remarkably high in the ....Complications during pregnancy, birth asphyxia or premature birth can lead to neurological impairment in the newborn. Despite excellent neonatal care many of these babies go on to have serious handicaps. Neurosteroids are a group of steroids that regulate brain activity. These steroids protect brain cells from damage caused by an inadequate supply of oxygen by suppressing toxicity caused by excessive activity. We have shown that the levels of these protective steroids are remarkably high in the fetal brain and levels rise further in response to fetal stress. The placenta contributes steroid precursors that help maintain these high neurosteroid levels. This placenta-fetal brain interaction comprises an internal mechanism that protects the fetal brain from adverse events during pregnancy. At birth, however, there is a dramatic decline in neurosteroid concentrations in the brain after the loss of the placental precursor supply. The fall in concentrations is even greater in animals that are born growth restricted. This suggests that newborns, particularly those from compromised pregnancies, are at increased risk of brain damage due to low neurosteroid levels. We believe that certain commonly used steroid therapies may also lower steroid levels in the brain and result in increased vulnerability to brain damage during birth or in the early neonatal period. Alternatively, we propose that replacement of neurosteroid precursors in the newborn may raise brain neurosteroid levels and protect against brain damage. In the proposed studies we will evaluate treatments that can raise the concentration of steroids and determine the best strategy for reducing brain injury following complications during pregnancy, at birth and during the early newborn period. This work will determine the best therapeutic approaches for maximising neurosteroid-induced brain protection and for reducing the risk of brain damage.Read moreRead less
Neuroactive Steroids In The Developing Brain: Potential For Preventing Perinatal Brain Damage
Funder
National Health and Medical Research Council
Funding Amount
$481,500.00
Summary
Complications during pregnancy, birth asphyxia or premature birth can lead to serious neurological impairment in the newborn. Despite excellent neonatal care many of these babies go on to have serious handicaps. Neuroactive steroids are a group of neuromodulators that are derived from the hormone progesterone. These steroids fall into two groups, those that appear to protect brain cells from damage caused by an inadequate supply of oxygen and those that may increase cell death. We have shown tha ....Complications during pregnancy, birth asphyxia or premature birth can lead to serious neurological impairment in the newborn. Despite excellent neonatal care many of these babies go on to have serious handicaps. Neuroactive steroids are a group of neuromodulators that are derived from the hormone progesterone. These steroids fall into two groups, those that appear to protect brain cells from damage caused by an inadequate supply of oxygen and those that may increase cell death. We have shown that protective neuroactive steroids are present in very large amounts in the fetal brain. Steroids produced by the placenta are converted to these neuroactive products by enzymes in the brain leading to the high levels that are seen during fetal life. Certain adverse conditions during pregnancy as well as preterm birth may cause marked changes in the balance of steroids that could increase susceptibility to brain injury. We have found that areas of the brain, where damage most often occurs, normally contain the highest amount of protective steroids, but only in late pregnancy. This suggests that disturbances that lower steroid production in these areas could contribute to the death of cells, particularly in mid-pregnancy and after premature birth. In the proposed studies, we will examine whether a toxic balance of steroids develops following adverse events in pregnancy as well as the areas of the brain where this is most pronounced. We will examine the changes in the expression of enzymes that can potentially cause the accumulation of protective steroids in the brain. We will then examine treatments that can raise the concentration of steroids and determine which combination of steroids best reduces cell death and brain injury following complications during pregnancy. The findings of this work will indicate the best therapeutic approach that may be adopted to modify the concentration of certain steroids so as to reduce the risk of brain damage in the fetus and neonate.Read moreRead less
Online and offline social networks and the development of sexual agency. This project will explore whether there exists a relationship between adolescents' social networks (both online and offline) and one important aspect of healthy sexual development - the development of sexual agency - and if so, it will investigate the nature of that relationship. The longitudinal mixed methods study proposed here aims to capture the development of sexual behaviours and the online and offline interactions ad ....Online and offline social networks and the development of sexual agency. This project will explore whether there exists a relationship between adolescents' social networks (both online and offline) and one important aspect of healthy sexual development - the development of sexual agency - and if so, it will investigate the nature of that relationship. The longitudinal mixed methods study proposed here aims to capture the development of sexual behaviours and the online and offline interactions adolescents engage in. This project aims to determine: whether there is a relationship between adolescents' online and offline social networks and the development of sexual agency; if such a relationship exists, what is its nature? And, if the relationship exists, to what extent is the relationship moderated by online social media use?Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102878
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Mobile phone text reminders to modify behaviours and prevent cardiovascular disease. Strategies are needed to improve adherence to behavioural and medical preventative treatments for heart disease. Brief informative reminders sent via mobile phone text message have potential as a cheap and safe method of improving behavioural change and adherence to treatments in people at risk of cardiovascular disease.