Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors w ....Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors will be used to devise a simple portable colorimetric test that can be performed in the vineyard or the winery. The ability to rapidly determine the level of grape contamination with phenolic glucosides would give Australian wine growers and wine makers a powerful tool to mitigate the effects of bushfires.Read moreRead less
A new generation high crash energy absorbing barrier for improved road safety. The new, high energy absorbing road safety barrier developed in this project will provide better protection for all road users than current barriers by reducing the severity of car crashes. Current road barriers result in an average loss of 1600 lives in Australia annually, including a disproportionate number of young lives. The new barrier will be highly efficient in absorbing collisions from vehicles travelling at s ....A new generation high crash energy absorbing barrier for improved road safety. The new, high energy absorbing road safety barrier developed in this project will provide better protection for all road users than current barriers by reducing the severity of car crashes. Current road barriers result in an average loss of 1600 lives in Australia annually, including a disproportionate number of young lives. The new barrier will be highly efficient in absorbing collisions from vehicles travelling at speeds between 60 to over a 100 kilometres per hour. Installation of the new road safety barrier systems in high accident zones will save lives by reducing the severity of accidents involving road barriers. This will significantly benefit the community by reducing injury, medical, rehabilitation and property damage costs, and improve quality of life for all road users.Read moreRead less
Plant based foods: Towards sustainable and acceptable meat analogues. The project aims to address the need for engineering plant-based food products to deliver a sensory experience akin to meat. The project expects to generate new knowledge on the structural drivers for emulating meat-like texture and taste within burger products. Expected outcomes of this project include new ingredients and food characterisation methodologies, including rheology and sensory, which can be employed in rational ....Plant based foods: Towards sustainable and acceptable meat analogues. The project aims to address the need for engineering plant-based food products to deliver a sensory experience akin to meat. The project expects to generate new knowledge on the structural drivers for emulating meat-like texture and taste within burger products. Expected outcomes of this project include new ingredients and food characterisation methodologies, including rheology and sensory, which can be employed in rational food structure design. This should provide significant benefits in enhancing the consumer acceptance of plant-based foods that is required to support the rapidly growing market opportunity for them and sustainable food production.Read moreRead less
Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological method ....Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological methods. This work is expected to determine how nanomaterials’ attributes direct pathways for liver cell disposal and describe nanomaterial–liver interactions at the cellular level, information crucial in enabling safer nanomaterials for use in products such as drug formulations, sunscreens and cosmetics.Read moreRead less
Towards autonomous structural safety prognostics: integrating in-situ imaging and predictive modelling. This project aims to advance a scientific basis for autonomous safety prognostics by developing predictive models and in-situ damage imaging principles. Development of this new health prognostic approach will overcome the significant challenge of safety assurance of composite structures in the presence of in-service damage, which is largely hidden.
Enabling the design of superior healthy snack foods and beverages through innovative assessment of oral processing and mucosal film interactions. Reducing sugar and fat in foods generally leads to products that are perceived as less flavoursome and appealing. A significant contributor to this is the interaction of foods and beverages with oral mucosal substrates, which play a key role in perceptual processes that drive unacceptable mouthfeel sensations. This project seeks to develop and use oral ....Enabling the design of superior healthy snack foods and beverages through innovative assessment of oral processing and mucosal film interactions. Reducing sugar and fat in foods generally leads to products that are perceived as less flavoursome and appealing. A significant contributor to this is the interaction of foods and beverages with oral mucosal substrates, which play a key role in perceptual processes that drive unacceptable mouthfeel sensations. This project seeks to develop and use oral mimetic substrates to permit objective and quantified rheological and tribological responses, imitating the underlying physics occurring during food oral processing that drive dynamic sensory responses. The project aims to enable a mechanism-based approach to minimise the amounts of fat, salt and sugar required for sensory properties that meet consumer expectations.Read moreRead less
Nonlinear frequency mixing methods for materials and damage evaluation. This project aims to investigate new approaches for frequency mixing in nonlinear ultrasonics, and to demonstrate their potential for the non-destructive evaluation of material degradation and early damage detection. The anticipated outcomes will be increased detection sensitivity relative to current inspection techniques and an enhanced capability for quantifying the damage. This will provide the basis for more cost efficie ....Nonlinear frequency mixing methods for materials and damage evaluation. This project aims to investigate new approaches for frequency mixing in nonlinear ultrasonics, and to demonstrate their potential for the non-destructive evaluation of material degradation and early damage detection. The anticipated outcomes will be increased detection sensitivity relative to current inspection techniques and an enhanced capability for quantifying the damage. This will provide the basis for more cost efficient safety management of high-value assets and infrastructure, and for enhancing Australia’s competitiveness in advanced manufacturing.Read moreRead less
Engineering biomimetic lubrication with mucin. Engineering coatings for water to be an effective lubricant is a significant challenge. The project seeks to emulate how nature builds highly lubricating water-rich polymer films on biological surfaces. This is intended to be achieved by directing the self-assembly of mucin macromolecules onto polymer brushes attached to a substrate, and then cross-linking the constituents to obtain a hydrated gel-like lubricating coating. This research is expected ....Engineering biomimetic lubrication with mucin. Engineering coatings for water to be an effective lubricant is a significant challenge. The project seeks to emulate how nature builds highly lubricating water-rich polymer films on biological surfaces. This is intended to be achieved by directing the self-assembly of mucin macromolecules onto polymer brushes attached to a substrate, and then cross-linking the constituents to obtain a hydrated gel-like lubricating coating. This research is expected to provide new insights on the mechanisms by which mucin-rich fluids lubricate and protect biosurfaces, which is important to human health, nutrition and well-being. It may also lead to new discoveries for engineering surface coatings for biomaterials and nanomaterials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100174
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons. Synchrotron science dramatically affects the community through the innovative scientific, engineering and medical research outcomes it produces. This program for access to synchrotron beamlines is aimed at enhancing Australia's high international standing in synchrotron science and will have many flow-on effects in areas such as health and ind ....Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons. Synchrotron science dramatically affects the community through the innovative scientific, engineering and medical research outcomes it produces. This program for access to synchrotron beamlines is aimed at enhancing Australia's high international standing in synchrotron science and will have many flow-on effects in areas such as health and industry.Read moreRead less