Phenotypic differences in behaviour, brain function and structure of genetically dissimilar forms of intellectual disability. How is the brain of someone with intellectual disability different from that of a normal person? Are behavioural phenotypes such as intellectual disability more related to similarities in brain structure and function than to the genotypic anomaly? This project will use neuroscience techniques of psychophysics, electrophysiology and fMRI to probe these questions. The ben ....Phenotypic differences in behaviour, brain function and structure of genetically dissimilar forms of intellectual disability. How is the brain of someone with intellectual disability different from that of a normal person? Are behavioural phenotypes such as intellectual disability more related to similarities in brain structure and function than to the genotypic anomaly? This project will use neuroscience techniques of psychophysics, electrophysiology and fMRI to probe these questions. The benefit of this project is that cortical flattening fMRI techniques together with new and efficient stimulus paradigms will result in a functional landmark mapping tool capable of application to many other brain genotype-phenotype questions. Also, the functional brain basis of intellectual disability will be further revealed.Read moreRead less
Predicting Behaviour from Brain Representations. This project aims to advance our understanding of how perceptual information is represented in the human brain and to link the structure of perceptual brain representations to human behaviour. The project plans to use complementary methods for recording brain activity (human neuroimaging and primate single-cell neurophysiology) and cutting-edge analytic techniques to generate a predictive model of behaviour based on the structure of perceptual bra ....Predicting Behaviour from Brain Representations. This project aims to advance our understanding of how perceptual information is represented in the human brain and to link the structure of perceptual brain representations to human behaviour. The project plans to use complementary methods for recording brain activity (human neuroimaging and primate single-cell neurophysiology) and cutting-edge analytic techniques to generate a predictive model of behaviour based on the structure of perceptual brain representations. It is anticipated that the results will significantly advance the field of cognitive neuroscience by providing a novel empirical framework for understanding how brain representations are predictive of behaviour.Read moreRead less
Chronic pain and functional impairment following traumatic injury: an investigation into the impact of compensation status and experience. This project will enhance understanding of the impact of the psychosocial factors and the compensation process on recovery from traumatic injury. The project will generate new resources (screening and referral guidelines; educational materials) to improve decision making consistency, client experience, and recovery from road trauma.
Using shape change for object perception: human and artificial vision. This project aims to examine the steps taken by the visual system to code the shape of objects, including those that change shape over time. The project seeks to employ experiments assessing human vision and machine learning techniques to examine these codes and, in particular, focus on the advantages of a system that exaggerates shape change over time. Expected outcomes include an improved shape code based on superior human ....Using shape change for object perception: human and artificial vision. This project aims to examine the steps taken by the visual system to code the shape of objects, including those that change shape over time. The project seeks to employ experiments assessing human vision and machine learning techniques to examine these codes and, in particular, focus on the advantages of a system that exaggerates shape change over time. Expected outcomes include an improved shape code based on superior human performance that can have many applications in automated visual systems. This project can directly benefit the animation industries where the creation of realistic movement of humans and animals remains a computationally intensive challenge.Read moreRead less
The brain in real time: a neural model of rhythmic action and perception. This project aims to study a fundamental function of the human brain: its temporal architecture. It will provide an innovative perspective on the neural mechanisms underlying and relating perception, intention, and voluntary action in real time, though a combination of eye-tracking, behaviour, and neural recordings. By providing a common language with which to relate perception, cognition, volition and action, this will ....The brain in real time: a neural model of rhythmic action and perception. This project aims to study a fundamental function of the human brain: its temporal architecture. It will provide an innovative perspective on the neural mechanisms underlying and relating perception, intention, and voluntary action in real time, though a combination of eye-tracking, behaviour, and neural recordings. By providing a common language with which to relate perception, cognition, volition and action, this will provide significant benefits that will transform the way we think about brain function.Read moreRead less
Parallel and generative binding in human visual cortex. Imagine watching a group of children running around in brightly coloured T-shirts. How does your brain keep track of which colour goes with which T-shirt goes with which child? This project will use magnetic resonance imaging to identify where in our brains information about colour, shape and motion gets put together.
The rules governing combined rod and cone photoreceptor signalling in visual pathways. The research program investigates vision at dim (mesopic) light levels where rod and cone photoreceptors simultaneously transmit visual information. The interaction between rod and cone signals is not trivial because their different amplitudes, timings and delays significantly change the perceptual qualities of our visual experience. The research addresses fundamental questions about how the retina and brain i ....The rules governing combined rod and cone photoreceptor signalling in visual pathways. The research program investigates vision at dim (mesopic) light levels where rod and cone photoreceptors simultaneously transmit visual information. The interaction between rod and cone signals is not trivial because their different amplitudes, timings and delays significantly change the perceptual qualities of our visual experience. The research addresses fundamental questions about how the retina and brain integrate disparate signals from the rods and cones to produce a homogenous visual percept. New psychophysical and electroretinographic paradigms will independently control the retinal photoreceptors to resolve the long standing problem of how noise modifies signalling and information flow between the retina and visual cortex.Read moreRead less
Adaptation and after effects in perception of tactile motion. This project investigates sensory properties of the skin covering the human hand, focusing on the ability to perceive how surfaces move across the palm when objects are handled or explored. This project aims to elucidate sensory information processing, leading to applications in diagnostics of neurological disorders and robotics.
Melanopsin function in humans. This project aims to understand melanopsin signalling in humans. A newly discovered retinal ganglion cell class expresses the melanopsin photopigment. Melanopsin signalling controls neural functions for light dependent image formation and non-image forming processes. Many of these are unknown in humans. This project will use a 5-primary photostimulator to define how melanopsin controls these processes in humans. The outcomes are expected to advance understanding of ....Melanopsin function in humans. This project aims to understand melanopsin signalling in humans. A newly discovered retinal ganglion cell class expresses the melanopsin photopigment. Melanopsin signalling controls neural functions for light dependent image formation and non-image forming processes. Many of these are unknown in humans. This project will use a 5-primary photostimulator to define how melanopsin controls these processes in humans. The outcomes are expected to advance understanding of human vision. This could provide avenues for using light to increase active participation in society and improve health and well-being, and strategies to assess human vision and the body’s internal clock.Read moreRead less
Information Encoding By Temporal Structure Of Afferent Spike Trains
Funder
National Health and Medical Research Council
Funding Amount
$231,175.00
Summary
Our ability to sense, discriminate and interpret touch stimuli underpins some of the most crucial functions of the human hand that relate to object exploration and manipulation. The fundamental mechanism of how nerve impulses generated by tactile receptors are interpreted by the nervous system is not understood. Only by discovering the underlying neural encoding mechanisms can we appreciate the functional impairments in patients and learn to identify them before they become widespread and irreve ....Our ability to sense, discriminate and interpret touch stimuli underpins some of the most crucial functions of the human hand that relate to object exploration and manipulation. The fundamental mechanism of how nerve impulses generated by tactile receptors are interpreted by the nervous system is not understood. Only by discovering the underlying neural encoding mechanisms can we appreciate the functional impairments in patients and learn to identify them before they become widespread and irreversible.Read moreRead less