Shifting the trend in radical battery research . The project aims to address a growing problem of increasing energy consumption by storing intermittent energy from the sun in affordable and efficient flow batteries. The project expects to generate new knowledge in the areas of materials science and battery research by using innovative theoretical chemistry approaches to studying electrochemical properties of nitroxide radicals in ionic media. The project aims to develop radical organic flow batt ....Shifting the trend in radical battery research . The project aims to address a growing problem of increasing energy consumption by storing intermittent energy from the sun in affordable and efficient flow batteries. The project expects to generate new knowledge in the areas of materials science and battery research by using innovative theoretical chemistry approaches to studying electrochemical properties of nitroxide radicals in ionic media. The project aims to develop radical organic flow batteries by utilising ionic liquids to stabilise radicals. Intended outcomes of the project include improved efficiency of flow batteries that can store energy from widely used solar panels. This should provide significant benefits to Australia’s effort to switch to renewable energy technologies. Read moreRead less
The role of hypohalous acids and related oxidants in the oxidative damage of biological systems: a computational investigation. The aim of this project is to decipher the molecular mechanisms of key reactions involved in oxidative damage to biomolecules. The study will lead to a better understanding of oxidative stress in biological systems and its role in chronic inflammatory disease, heart disease, and cancer.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100222
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Advanced stopped flow: electron paramagnetic resonance apparatus for measurement of short-lived free radicals in engineering, science and medicine. The facility will enable world class research into complex chemical processes relevant to industry, environmental science and biochemistry. This will result in development of new technologies in explosives, pollution reduction and energy storage, and enhance our understanding of chemical processes that lead to sperm deoxyribonucleic acid (DNA) damage ....Advanced stopped flow: electron paramagnetic resonance apparatus for measurement of short-lived free radicals in engineering, science and medicine. The facility will enable world class research into complex chemical processes relevant to industry, environmental science and biochemistry. This will result in development of new technologies in explosives, pollution reduction and energy storage, and enhance our understanding of chemical processes that lead to sperm deoxyribonucleic acid (DNA) damage and infertility.Read moreRead less
A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Role Of Transition Metal Ions And Redox Activity In The Development Of Atherosclerotic Plaques
Funder
National Health and Medical Research Council
Funding Amount
$196,018.00
Summary
Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability ....Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability to generate free radicals is controversial. This study will employ a novel, minimally-invasive, technique to assess the nature and quantity of metal ions present in well-defined human and animal lesions at different stages of lesion development. The ability of these metal ions to catalyse free radical formation from components present in the artery wall will also be assessed. The release of these metal ions from the artery wall to added organic molecules will be assessed as this might minimise their potential to cause damage, and provide a possible therapeutic strategy. These studies will therefore provide valuable information as to the significance and role of reactive metal ions in the development of human artery disease and the possible prevention, or minimisation, of such processes.Read moreRead less
Light Activated Electrochemistry: Microelectrode Arrays with just one wire. Electrochemistry requires each electrode to be connected to the external circuit by a wire. With many electrodes this means many wires. Wires limit electrode density in arrays and dictate that the electrode architecture must be predetermined. This project aims to remove the need for a wire for each electrode by using light to sequentially connect each electrode to a single wire. This will be achieved using modified silic ....Light Activated Electrochemistry: Microelectrode Arrays with just one wire. Electrochemistry requires each electrode to be connected to the external circuit by a wire. With many electrodes this means many wires. Wires limit electrode density in arrays and dictate that the electrode architecture must be predetermined. This project aims to remove the need for a wire for each electrode by using light to sequentially connect each electrode to a single wire. This will be achieved using modified silicon electrodes where irradiating with light causes an increase in conductivity at the illumination spot. The project will explore the variables that influence the spatial resolution and apply the ideas to making soft connects for nanoelectronics and making high density electrode arrays for electroanalysis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100732
Funder
Australian Research Council
Funding Amount
$359,544.00
Summary
Electrostatic Catalysis: guiding reactive interfaces using electric fields. This project seeks to gain quantitative understanding of the role of electrostatics over chemical processes. Chemical transformations of organic compounds at interfaces underpin some of the most important processes, from the production of fine chemicals for pharmaceuticals to assisting bio-degradation of pollutants in clean technologies. Recent computational studies suggest that by applying oriented electric fields at in ....Electrostatic Catalysis: guiding reactive interfaces using electric fields. This project seeks to gain quantitative understanding of the role of electrostatics over chemical processes. Chemical transformations of organic compounds at interfaces underpin some of the most important processes, from the production of fine chemicals for pharmaceuticals to assisting bio-degradation of pollutants in clean technologies. Recent computational studies suggest that by applying oriented electric fields at interfaces, the rate and the selectivity of chemical processes can be altered at will. The project intends to test these theoretical findings. The knowledge generated by this research may translate into new technologies for the fine-chemical and biotechnology industries.Read moreRead less
Ionic lquids for scalable production of monolayer two-dimensional materials. This project aims to produce stable solutions of high quality, two-dimensional materials (2DMs, exemplified by graphene) in ionic liquids by spontaneous exfoliation. The project will develop processes for producing significant quantities of high quality 2DMs for use in a diverse range of technologies, and train graduate students in experimental and computational chemistry techniques.
Hirshfeld surfaces in molecular crystals: Revolutionary tools for crystal engineers. Crystal engineering is an exciting modern branch of chemistry that seeks to understand intermolecular interactions in the context of crystal packing, and to use this understanding in the design of new materials with desirable physical and chemical properties. This project will considerably extend our already significant contribution to the detailed analysis of intermolecular interactions in molecular crystal st ....Hirshfeld surfaces in molecular crystals: Revolutionary tools for crystal engineers. Crystal engineering is an exciting modern branch of chemistry that seeks to understand intermolecular interactions in the context of crystal packing, and to use this understanding in the design of new materials with desirable physical and chemical properties. This project will considerably extend our already significant contribution to the detailed analysis of intermolecular interactions in molecular crystal structures. It will achieve this by a substantial enhancement of our novel visualization tools, by improving upon current approaches to the analysis of theoretical and experimental crystalline electron distributions for molecular materials, and by ensuring the widespread availability of resulting software to all researchers.Read moreRead less