Validation Of A Multiplexed Blood Based Screening Assay For The Diagnosis Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$556,712.00
Summary
Colorectal cancer (CRC) is the second most common cancer in Australia with poor patient outcome due to late detection of the disease. We have developed a simple blood based test that can diagnose individuals with CRC at an early stage when the chance of cure is greater than 80%.
Implementation Of A New, Inexpensive And High-throughput Matrix Assisted Laser Desorption / Ionization _ Time Of Flight Mass Spectrometry Test For Superior Detection Of Fragile X Syndrome In Targeted Diagnostics And Newborn Population Screening.
Funder
National Health and Medical Research Council
Funding Amount
$254,175.00
Summary
Background: The Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability. There are now a number of treatments for FXS. However, often this disorder is not clearly recognized. We have developed a novel FXS test that could resolve this issue. Our objective is to develop a commercial package that describes suitability of our test for diagnostic use. If successful this could potentially leading to improvement in the prognosis for FXS children through early treatment int ....Background: The Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability. There are now a number of treatments for FXS. However, often this disorder is not clearly recognized. We have developed a novel FXS test that could resolve this issue. Our objective is to develop a commercial package that describes suitability of our test for diagnostic use. If successful this could potentially leading to improvement in the prognosis for FXS children through early treatment intervention.Read moreRead less
The Clinical Value Of Serology And Molecular Tests For Diagnosing Invasive Aspergillosis In At-risk Hematology Patients
Funder
National Health and Medical Research Council
Funding Amount
$1,095,500.00
Summary
Aspergillus is a fungus found in soil, on farms and on construction sites. In those whose immune system is impaired it causes severe infection. The people who are particularly at high-risk of Aspergillus infection (called Invasive Aspergillosis) are those with acute leukaemia on chemotherapy or post bone marrow transplantation. Currently 15% of those at high-risk get Invasive Aspergillosis and 58-93% of those infected die. The main reason for this high death rate is that our current diagnostic t ....Aspergillus is a fungus found in soil, on farms and on construction sites. In those whose immune system is impaired it causes severe infection. The people who are particularly at high-risk of Aspergillus infection (called Invasive Aspergillosis) are those with acute leukaemia on chemotherapy or post bone marrow transplantation. Currently 15% of those at high-risk get Invasive Aspergillosis and 58-93% of those infected die. The main reason for this high death rate is that our current diagnostic tests are not good at detecting infection or often only detect the infection at advanced stages when treatment is ineffective. Because of the limitations of current diagnostic tests the current practice is to give empiric antifungal therapy (EAFT) early to treat Invasive Aspergillosis. However studies have demonstrated that this therapy has only resulted in a minor reduction in the mortality rates and it causes significant drug toxicity. It is a suboptimal treatment modality. New tests have been developed to diagnose Invasive Aspergillosis. These tests are for the detection of an Aspergillus protein in blood and for the detection of Aspergillus DNA in the blood. Available data suggests that these new tests are sensitive in the detection of Invasive Aspergillosis. Also other studies suggest that these new tests make an early diagnosis and seem to be able to monitor responses to treatment. However no study has been performed to date which demonstrates that the use of these tests can impact on important patient outcomes. This trial is designed to determine whether the use of the new tests to guide therapy will help improve treatment of Invasive Aspergillosis, reduce drug toxicity and reduce the death rate in the high-risk patients as compared with the current standard method of diagnosis and treatment with EAFT. If the trial is successful then this represents a significant advancement in the treatment and survival of leukaemic and bone marrow transplantation patients.Read moreRead less
Ultrafast Photonic Electron Microscopy: Visualising dynamics at the nanoscale. The dynamics of molecular processes are too fast to observe with any microscope so science has instead relied on recording the static before and after states of these changes, inferring what happens in between. This project aims to combine the advantages of ultrafast photonic laser control and electron microscopy to allow the direct visualisation of dynamics at the nanoscale in physical and biological systems. By prov ....Ultrafast Photonic Electron Microscopy: Visualising dynamics at the nanoscale. The dynamics of molecular processes are too fast to observe with any microscope so science has instead relied on recording the static before and after states of these changes, inferring what happens in between. This project aims to combine the advantages of ultrafast photonic laser control and electron microscopy to allow the direct visualisation of dynamics at the nanoscale in physical and biological systems. By providing a view into how order emerges from the thermal chaos of molecular objects this project aims to help to reveal the physical basis for life.Read moreRead less
New generation pulsed magnetron sputtering for the synthesis of advanced materials. Magnetron sputtering underpins the manufacture of many products ranging from semiconductor microelectronics to energy efficient windows. This project will create a new generation sputtering process fully compatible with current technology but capable of synthesising new phases and new film microstructures with greatly enhanced performance.
Prediction of solar activity and space weather by automated analyses of solar radio and magnetic field observations and simulations. This project will build world-recognised capabilities to forecast space weather events at Earth in time to take protective measures. It involves around the clock automated identification and analysis of specific solar radio bursts, forecasting solar activity that results in transients moving Earth-ward, and simulations to predict when these will reach Earth.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100021
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A diagnostics platform for advanced plasma-chemical analysis. A wide range of production processes involve the use of plasmas to modify materials, but they are not well understood. This project will give Australian researchers the tools to look inside plasma processes and fully characterise them for the first time, unlocking new knowledge and providing new insight into the plasma processing environment.
Bright x-ray beams from laser-driven microplasmas. This project aims to develop a new generation of bright, laser-like x-ray sources for laboratory use. X-ray sources underpin key diagnostic techniques in materials science, advancing applications from structural engineering through to ore processing and energy storage. However, the limited brightness of present-day laboratory x-ray sources restricts the utility and range of these diagnostic techniques. This research intends to use intense lasers ....Bright x-ray beams from laser-driven microplasmas. This project aims to develop a new generation of bright, laser-like x-ray sources for laboratory use. X-ray sources underpin key diagnostic techniques in materials science, advancing applications from structural engineering through to ore processing and energy storage. However, the limited brightness of present-day laboratory x-ray sources restricts the utility and range of these diagnostic techniques. This research intends to use intense lasers to create microscopic plasmas and drive high harmonic generation. The high harmonic generation process is already used to create laser-like ultraviolet light. By optimising the characteristics of the plasma medium, the project aims to extend bright high harmonic generation to the x-ray regime.Read moreRead less
Numerical modelling of the solar atmosphere. This project will develop a complete and realistic model of the magnetic solar activity using computer simulations of the interconnected solar interior and atmosphere. The results of this project will provide a deeper insight into the physical processes behind solar activity phenomena and will help in the development of methods of solar activity prediction.