Gravity Current Driven Smoke Dispersion In a Stratified Ambient. Smoke from bushfires transported by gravity currents, and known to occur nationwide, caused the shutdown of businesses, education and events in Canberra in 2019. Recent scientific investigations have shown that the speed of propagation and concentration of smoke in these three-dimensional gravity currents have a long term ‘memory’ of their initial configuration. In this project, high-fidelity computational and experimental techniq ....Gravity Current Driven Smoke Dispersion In a Stratified Ambient. Smoke from bushfires transported by gravity currents, and known to occur nationwide, caused the shutdown of businesses, education and events in Canberra in 2019. Recent scientific investigations have shown that the speed of propagation and concentration of smoke in these three-dimensional gravity currents have a long term ‘memory’ of their initial configuration. In this project, high-fidelity computational and experimental techniques will be used to elucidate the fundamental mechanisms of gravity current entrainment and propagation. This knowledge will set a strong foundation to improve operational forecasts of smoke transport that will allow government agencies to better respond to the negative impact of these complicated flows.Read moreRead less
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Characterization of Fast Propagating Fires in Green Buildings. This project aims to gain a better understanding of the mechanisms of fast-propagating fires and to address the deficiency in current fire models in assessing the fire safety requirement of green buildings. Although there are many compelling advantages associated with green building designs, because they promote better natural ventilation they could pose a significant fire hazard to occupants due to the propensity of rapid fire and s ....Characterization of Fast Propagating Fires in Green Buildings. This project aims to gain a better understanding of the mechanisms of fast-propagating fires and to address the deficiency in current fire models in assessing the fire safety requirement of green buildings. Although there are many compelling advantages associated with green building designs, because they promote better natural ventilation they could pose a significant fire hazard to occupants due to the propensity of rapid fire and smoke spread within the enclosed space. The new predictive fire model in this project is expected to promote a safer and sustainable building environment.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100032
Funder
Australian Research Council
Funding Amount
$4,272,072.00
Summary
ARC Training Centre in Fire Retardant Materials and Safety Technologies. The ARC Training Centre in Fire Retardant Materials and Safety Technologies aims to train a cohort of industry-focused researchers to improve the fire safety of lightweight materials and structures and fire protection systems. The Training Centre expects to create knowledge on novel green and durable fire retardant materials, advanced fire models for urban and built environment, fire suppression technologies, and new flamma ....ARC Training Centre in Fire Retardant Materials and Safety Technologies. The ARC Training Centre in Fire Retardant Materials and Safety Technologies aims to train a cohort of industry-focused researchers to improve the fire safety of lightweight materials and structures and fire protection systems. The Training Centre expects to create knowledge on novel green and durable fire retardant materials, advanced fire models for urban and built environment, fire suppression technologies, and new flammability tests for compliance with fire safety regulatory standards. An expected outcome of this Training Centre is to accelerate the transformation of Australia’s industries in fire retardant materials, products and engineering services.Read moreRead less
Enabling low greenhouse gas emissions from road vehicles through the proper use of alternative fuels. A major increase in alternative transport fuel use appears necessary in our response to the challenges of climate change and energy security. This proposal will advance our fundamental understanding of key aspects of the combustion of particular alternative fuels, thus enabling proper engine design and so maximising greenhouse and energy security benefits. Further, the Australian automotive indu ....Enabling low greenhouse gas emissions from road vehicles through the proper use of alternative fuels. A major increase in alternative transport fuel use appears necessary in our response to the challenges of climate change and energy security. This proposal will advance our fundamental understanding of key aspects of the combustion of particular alternative fuels, thus enabling proper engine design and so maximising greenhouse and energy security benefits. Further, the Australian automotive industry is a major employer and exporter, and needs to develop and/or maintain international leadership in low emission technologies to ensure its long term viability. This proposal builds a consortium of local organisations with common interests, thus helping local industry respond to several, significant challenges that they presently face.Read moreRead less
Endocrine And Molecular Regulation Of Placental CRH Expression
Funder
National Health and Medical Research Council
Funding Amount
$466,980.00
Summary
Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotr ....Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotrophin releasing hormone, CRH) in the placenta and the length of time the baby is carried in the mother. In women who will deliver prematurely a rise in CRH occurs earlier in the pregnancy and more rapidly, while in women who deliver late the rise occurs more slowly. This work has given rise to the concept of a biological clock that determines the length of time the fetus will be carried by the mother before birth, and in which production of CRH in the placenta plays a central role. We have been studying how the CRH gene is controlled in placental cells. We have discovered some regions in the DNA of the CRH gene which have important roles in controlling how much CRH is made by the placenta. The experiments described in this research project will determine the molecular mechanisms that control the production of CRH in the human placenta. This will be done in two ways: (1) by examining the DNA sequences involved in controlling expression of the CRH gene and (2) by identifying the proteins that actually perform the regulating functions that result in either increased or decreased amounts of CRH being produced by the placenta. This important information will help us better understand how normal and abnormal birth is controlled, and from that knowledge new ways to detect and prevent premature birth can be invented.Read moreRead less
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Understanding the Origin and Development of Extreme and Mega Bushfires. Extreme and megafires result in significant damage to property and infrastructure and are associated with large suppression costs. These events form when separate fires Merge. Their increase occurrence in recent seasons highlights the importance of developing tools and technologies that better predict extreme events to aid fire response and inform strategies for greater resilience. This project combines fire field experiment ....Understanding the Origin and Development of Extreme and Mega Bushfires. Extreme and megafires result in significant damage to property and infrastructure and are associated with large suppression costs. These events form when separate fires Merge. Their increase occurrence in recent seasons highlights the importance of developing tools and technologies that better predict extreme events to aid fire response and inform strategies for greater resilience. This project combines fire field experiments with computer modelling to determine factors driving extreme fire development, and develop new knowledge and models. These enable better prediction of active fires, enhance the knowledge base of fire managers for critical decision making and to improve risk modelling and mitigation planning for fire-prone communities.Read moreRead less
Development and application of a virtue experimental blast furnace. This project aims to develop a virtual experimental blast furnace based on advanced discrete particle simulation technique. It is intended that the model furnace will be used to study the flow and thermochemical behaviour in iron making, quantify the effects of key variables related to raw material and operational conditions, and formulate strategies for optimum process design and control under different conditions. The findings ....Development and application of a virtue experimental blast furnace. This project aims to develop a virtual experimental blast furnace based on advanced discrete particle simulation technique. It is intended that the model furnace will be used to study the flow and thermochemical behaviour in iron making, quantify the effects of key variables related to raw material and operational conditions, and formulate strategies for optimum process design and control under different conditions. The findings aim to be very useful to comprehensively assess the performance of Australian minerals in iron making, improve the energy efficiency and reduce carbon dioxide emission in the steel industry, and enhance the competitiveness of the Australian economy.Read moreRead less
Multiscale modelling of the transport phenomena of liquid iron and slag in ironmaking blast furnace. Blast furnace ironmaking is a key operation in the steel industry which, with an annual turnover around $11 billion, is a significant manufacturing sector in Australia. This project, focused on the behaviour of liquid iron and slag, can generate computer models that can reliably describe the complicated multiphase flow and thermochemical processes in the furnace. The implementation of the resulta ....Multiscale modelling of the transport phenomena of liquid iron and slag in ironmaking blast furnace. Blast furnace ironmaking is a key operation in the steel industry which, with an annual turnover around $11 billion, is a significant manufacturing sector in Australia. This project, focused on the behaviour of liquid iron and slag, can generate computer models that can reliably describe the complicated multiphase flow and thermochemical processes in the furnace. The implementation of the resultant models and the new understanding should lead to long life campaigns, better operational control, decreased fuel consumption, improved productivity and reduced environmental impact. This, together with the proposed research training, is important to the development of Australia's competitive steel industry.Read moreRead less