Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Improving the Governance of Species Lists. The aim of this project is to develop a system of governance for the creation of taxonomic lists. This project expects to apply knowledge of how other science organizations govern themselves to the governance of taxonomic lists, estimate the costs of current inefficiencies and identify impediments to improvement. Expected outcomes of this project include a process for validating global lists of species. This should provide significant benefits, such as ....Improving the Governance of Species Lists. The aim of this project is to develop a system of governance for the creation of taxonomic lists. This project expects to apply knowledge of how other science organizations govern themselves to the governance of taxonomic lists, estimate the costs of current inefficiencies and identify impediments to improvement. Expected outcomes of this project include a process for validating global lists of species. This should provide significant benefits, such as single lists of species that can be adopted at any scale and are readily comparable across countries and applications. A single list will ensure threatened species and those of quarantine or health concern don’t fall through the cracks and cause problems.Read moreRead less
The impacts of commercial gambling on Aboriginal communities in Northern Australia. The project will represent the first detailed exploration of the effects of commercial gambling on Aboriginal people in Northern Australia. It specifically aims to assess the impact of continued commercial gambling expansion, including the spread of electronic gaming machines (EGMs), on Aboriginal communities. The project will explore how Aboriginal cultures react to, and adopt, western gambling into existing cul ....The impacts of commercial gambling on Aboriginal communities in Northern Australia. The project will represent the first detailed exploration of the effects of commercial gambling on Aboriginal people in Northern Australia. It specifically aims to assess the impact of continued commercial gambling expansion, including the spread of electronic gaming machines (EGMs), on Aboriginal communities. The project will explore how Aboriginal cultures react to, and adopt, western gambling into existing cultural frameworks. The core task of the project will be to develop appropriate methodological tools for the assessment of gambling activity in Aboriginal communities. The result will have direct policy impacts in the context of regional well-being and identifying and protecting vulnerable communities.Read moreRead less
Wellbeing not Winning: remote Indigenous identity and organised sport. This project examines the construction of Indigenous identity through organised sport in remote communities. Despite high profile successes of Indigenous people in elite sports, the effectiveness of relationships between remote communities and organised sport is not well understood. This project addresses the problem of how participation in organised sport affects identity and everyday life in remote Indigenous communities, b ....Wellbeing not Winning: remote Indigenous identity and organised sport. This project examines the construction of Indigenous identity through organised sport in remote communities. Despite high profile successes of Indigenous people in elite sports, the effectiveness of relationships between remote communities and organised sport is not well understood. This project addresses the problem of how participation in organised sport affects identity and everyday life in remote Indigenous communities, both positively and negatively. The project aims to provide an understanding of the role of organised sport in Indigenous identity construction in remote Australia and thus open opportunities for equitable and reconciliatory modes of participation.Read moreRead less
Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We ....Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We will generate antibody fragments that bind these MP and express them in tomato. We will analyse antibody expression in tomato and study their association with the phytoplasma membrane. Transgenic plants will be inoculated with phytoplasma and monitored for resistance. This work represents a major step towards engineering resistance to phytoplasmas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less