Further Characterisation Of The Role Of HSSB1 In DNA Repair And Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$85,526.00
Summary
To date, all breast cancer predisposition genes identified play an important role in the DNA damage repair pathway. We have characterised a new protein designated as hSSB1, which plays a crucial role in the maintenance of genomic stability by protecting us from DNA damage. Significantly, evidence strongly suggests an interaction of hSSB1 with the breast cancer susceptibility protein BRCA2. This project will investigate the role of hSSB1 in breast cancer predisposition and DNA damage repair.
Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction: The Relationship Between Function And Neuromechanics
Funder
National Health and Medical Research Council
Funding Amount
$76,252.00
Summary
Anterior cruciate ligament (ACL) reconstruction allows most people to return to their previous level of function, but does not prevent the onset of knee osteoarthritis (OA). The development of OA in young people after ACL reconstruction may be caused by the initial injury, altered movement patterns, or changes in muscle control. This study will investigate the relationship between these factors. The findings will help to improve understanding of the causes of OA following ACL reconstruction.