Novel genomic technologies to improve fertility in northern beef cattle. This project aims to develop new genomic technologies to enable accelerated improvement of cow fertility. Increased global demand for beef is driving northern Australian beef enterprises to develop innovative ways to increase productivity. A substantial industry challenge is poor fertility of cows, with weaning rates frequently less than 40%. The expected outcomes of this project are an improvement in weaning rates to enabl ....Novel genomic technologies to improve fertility in northern beef cattle. This project aims to develop new genomic technologies to enable accelerated improvement of cow fertility. Increased global demand for beef is driving northern Australian beef enterprises to develop innovative ways to increase productivity. A substantial industry challenge is poor fertility of cows, with weaning rates frequently less than 40%. The expected outcomes of this project are an improvement in weaning rates to enable accelerated genetic gain for fertility in these enterprises by delivering a low cost array, which assays thousands of DNA variants affecting fertility simultaneously. This should provide significant benefits such as a new genomic prediction method informed by gene expression data from a unique resource of Brahman cattle with exceptionally high fertility, generating significant industry benefits.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Smarter fermentations through starter culture genomics. Australia makes over $1 billion dollars worth of cheese each year, however fermentation can be adversely affected by virus (phage) attack or sub-optimal strain mixtures. The latest genomics and molecular biology approaches will be used to characterise and optimise starter culture strains leading to improved flavour, quality and efficiency in cheese making.
Methods to infer dense genomic information from sparsely genotyped populations. Prediction of phenotype based on DNA polymorphisms or sequence has important applications such as prediction of disease risk in human medicine and prediction of genetic value in plant or animal breeding. This project will enhance precision and lower the cost of association studies leading to substantial increase in accuracy of such predictions. This will allow more effective genetic improvement, particularly of diff ....Methods to infer dense genomic information from sparsely genotyped populations. Prediction of phenotype based on DNA polymorphisms or sequence has important applications such as prediction of disease risk in human medicine and prediction of genetic value in plant or animal breeding. This project will enhance precision and lower the cost of association studies leading to substantial increase in accuracy of such predictions. This will allow more effective genetic improvement, particularly of difficult but important traits such as disease resistance, reduced green-house gas emissions and product quality. The same methods can be extended to improve genetic improvement in plants and better prediction of human disease risk. Read moreRead less
Generating a targeted mutation resource in zebrafish. How do genes function to build organisms and how are they regulated to produce organs and tissues? Using a new technique to target specific genes in the genome of zebrafish, this project will determine how genes control formation of different tissues. The new gene "knockout" technology will fundamentally change our understanding of how genes work during development.
Predicting Perfect Partners: climate resilient seed production technology . This project aims to increase productivity and profitability of the Australian sorghum industry in the face of risks imposed by an increasingly variable climate. This project expects to generate new knowledge of processes limiting hybrid seed production and translate this world-class research into tools and services that can be used by seed companies to improve its efficiency and reliability. The intended outcome will in ....Predicting Perfect Partners: climate resilient seed production technology . This project aims to increase productivity and profitability of the Australian sorghum industry in the face of risks imposed by an increasingly variable climate. This project expects to generate new knowledge of processes limiting hybrid seed production and translate this world-class research into tools and services that can be used by seed companies to improve its efficiency and reliability. The intended outcome will increase the security and sustainability of farming by minimising the risk of climate-induced seed shortages, maintaining Australia’s leadership in agricultural technology development. The expected benefits support profitable and productive businesses, providing Australian agriculture with a competitive, sustainable edge.Read moreRead less
Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health ser ....Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health service delivered to the Australian public. This project aims to develop better tests for application in prenatal diagnostics including non-invasive testing of fetal cells from maternal circulation or cervical samples at 6-13 weeks gestation, IVF and cancer diagnostics.Read moreRead less
Mapping recombination blocks in Brassica. DNA technology provides new ways to study genomes. Understanding how the genome behaves during plant breeding will help design strategies for the breeding and selection of improved crop plants.
Genomics to rust proof the humble oat. This project aims to reduce the impact of the damaging and currently intractable fungal pathogen crown rust (OCR) in Australian oat production. The expected project outcomes are: new sources of enduring high value resistance to OCR, tools to accelerate the use of these resistances, and locally adapted OCR resistant oat germplasm for use in developing profitable oat varieties. The project will use new approaches to tap very recently released genomic resource ....Genomics to rust proof the humble oat. This project aims to reduce the impact of the damaging and currently intractable fungal pathogen crown rust (OCR) in Australian oat production. The expected project outcomes are: new sources of enduring high value resistance to OCR, tools to accelerate the use of these resistances, and locally adapted OCR resistant oat germplasm for use in developing profitable oat varieties. The project will use new approaches to tap very recently released genomic resources and unique oat/ OCR resources assembled over many years. It will lead to responsible stewardship of broadly effective OCR resistance in grazing/milling/hay oats, increasing grower profitability, reducing reliance on fungicides, and underpinning planned growth in our export oat market. Read moreRead less
Identifying the diversity and evolution of loci associated with adaptation to aridity/heat and salinity in ancient cereal crops. This project will use ancient grains of wheat, barley and rye to find 'lost' genetic diversity at key genes associated with resistance to aridity, salt and disease. This project will make the proteins of key genes, and study their interaction with the environment over time by measuring ions in the grains to reveal the ancient environmental conditions.