Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237664
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT- ....High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT-ICR-MS will provide key structural information on a wide range of synthetic and natural chemical substances, including sequence (e.g. peptides) and fragmentation patterns, while the MALDI-TOF instrument will be used primarily for high through-put proteomic analyses.Read moreRead less
Intelligent CRM through Conjoint Data Mining of Heterogeneous Sources. This project aims to investigate and develop techniques to improve customer relationship management (CRM) for public and private organisations. It aims to develop an intelligent framework to assist in adaptive marketing and management of customers. The framework is designed to manage multiple information resources for information sharing, and to synthesise knowledge through visualisation. Intended outcomes are standardised XM ....Intelligent CRM through Conjoint Data Mining of Heterogeneous Sources. This project aims to investigate and develop techniques to improve customer relationship management (CRM) for public and private organisations. It aims to develop an intelligent framework to assist in adaptive marketing and management of customers. The framework is designed to manage multiple information resources for information sharing, and to synthesise knowledge through visualisation. Intended outcomes are standardised XML profiles for the different data sets and business processes, novel techniques for conjoint mining of structured and semi-structured data, and adaptive business intelligence techniques. The results will be validated using large real-world data sets provided by the partner organisation.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Springer fibres, nilpotent cones and representation theory. This project will address new ideas and famous unsolved problems in the field of algebra known as representation theory, by studying the geometry of spaces called Springer fibres and nilpotent cones. This will keep Australian mathematics in the forefront of developments in this internationally active field, which is central to modern mathematics.
ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environme ....ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environments. EII will address 3 tightly coupled research themes: Ability to interoperate across existing heterogenous platforms & applications; Efficient processing of very large data sets; Technology adoption & impact. Generic results will be applicable to e-science and large business information systems installations.Read moreRead less
Geodetic groups: foundational problems in algebra and computer science. The project aims to resolve important and longstanding open problems in Geometric Group Theory and Theoretical Computer Science. Since the 1980s researchers have conjectured that the geometric property of being geodetic is equivalent to several purely algebraic, algorithmic, and language-theoretic characterisations.
The project team's expertise in geodesic properties of groups, the interaction between formal languages and g ....Geodetic groups: foundational problems in algebra and computer science. The project aims to resolve important and longstanding open problems in Geometric Group Theory and Theoretical Computer Science. Since the 1980s researchers have conjectured that the geometric property of being geodetic is equivalent to several purely algebraic, algorithmic, and language-theoretic characterisations.
The project team's expertise in geodesic properties of groups, the interaction between formal languages and groups, and the theory of rewriting systems, together with recent breakthroughs by the team ensures that significant results can be expected.
Benefits include training research students and postdoctoral researchers in cutting-edge techniques, and advancing fundamental knowledge in mathematics and computer science.Read moreRead less
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.