Anti-sporulation Strategies For Clostridium Difficile Infections
Funder
National Health and Medical Research Council
Funding Amount
$651,559.00
Summary
Hospital-acquired infections with the bacterium Clostridium difficile are a major global public health concern with highly virulent isolates emerging overseas in 2002 and in Australia in 2010. These strains have spread through our hospitals and are also found in the community. This project will increase our understanding of how these strains spread and will provide knowledge that is critical for developing improved strategies for preventing these infections.
Discovery Early Career Researcher Award - Grant ID: DE180100202
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Interplay between plasticity and senescence. This project aims at bridging two fundamental human stressors together in a quantitative genetic framework. The environment changes globally on a huge scale coupled with effect on the age-structures and genetic composition of countless populations by over-harvesting and exploitation. This project will provide significant benefits, such as potential strategies of dealing with future human-induced changes more effectively.
Discovery Early Career Researcher Award - Grant ID: DE220100555
Funder
Australian Research Council
Funding Amount
$458,872.00
Summary
Identifying factors that counter negative impacts of ocean climate change. This project aims to identify factors that counter the negative impacts of climate change on coral reefs. This project expects to address key research gaps to ensure the persistence of these ecosystems. Expected outcomes of this project include identification of coral reefs that are buffered by adjacent systems, such as mangroves and seagrass, and characterisation of conditions (e.g. increased food availability) that allo ....Identifying factors that counter negative impacts of ocean climate change. This project aims to identify factors that counter the negative impacts of climate change on coral reefs. This project expects to address key research gaps to ensure the persistence of these ecosystems. Expected outcomes of this project include identification of coral reefs that are buffered by adjacent systems, such as mangroves and seagrass, and characterisation of conditions (e.g. increased food availability) that allow coral reefs and associated organisms to persist under stress. Outcomes of this project should provide significant benefits such as adding to the interventions toolbox in alleviating the impacts of global change on coral reefs and identifying conservation strategies to help prevent the loss of these valuable ecosystems.Read moreRead less
Re-EValuating The Inhibition Of Stress Erosions (REVISE): Gastrointestinal Bleeding Prophylaxis In ICU
Funder
National Health and Medical Research Council
Funding Amount
$2,955,164.00
Summary
Around 50,000 patients in Australian Intensive Care Units receive a drug called pantoprazole each year with the aim of preventing bleeding from the gut. Recent research suggests this practice is ineffective and may harm patients by increasing their risk of serious infections. We will perform a definitive study to determine whether the widespread use of pantoprazole is beneficial or harmful.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Adaptive capacity of marine invertebrates in a climate change ocean. As the oceans simultaneously warm and acidify, prospects for marine biota are of concern. This project aims to determine the potential for phenotypic adjustment and evolutionary adaptation. To discern the roles of phenotype and genotype in marine invertebrate stress tolerance this project endeavours to use selection experiments, long-term rearing and quantitative genetics . A focus on vulnerable calcification systems could dete ....Adaptive capacity of marine invertebrates in a climate change ocean. As the oceans simultaneously warm and acidify, prospects for marine biota are of concern. This project aims to determine the potential for phenotypic adjustment and evolutionary adaptation. To discern the roles of phenotype and genotype in marine invertebrate stress tolerance this project endeavours to use selection experiments, long-term rearing and quantitative genetics . A focus on vulnerable calcification systems could determine genetic mechanisms underlying impaired growth. Investigation of species from the east Australia latitudinal thermal gradient, a global change hot spot could generate insights into biological responses and adaptive potential in a changing ocean and on time scales relevant to resource managers to understand the challenges faced by marine biota.Read moreRead less
How climate-resilient are our temperate fisheries species? This project assesses the resilience of our temperate fisheries species to climate change. Using natural warming hotspots and volcanic CO2 vents we study populations of fisheries species that are already pre-adapted to future climate, and therefore could act as key populations for replenishment of future fisheries stocks. An innovative and interdisciplinary approach combines the ecology, genetics, behaviour, and physiology of fisheries s ....How climate-resilient are our temperate fisheries species? This project assesses the resilience of our temperate fisheries species to climate change. Using natural warming hotspots and volcanic CO2 vents we study populations of fisheries species that are already pre-adapted to future climate, and therefore could act as key populations for replenishment of future fisheries stocks. An innovative and interdisciplinary approach combines the ecology, genetics, behaviour, and physiology of fisheries species to evaluate their climate resilience. An advanced food web model will be developed to forecast changes to fisheries production in a future world. This provides a much-improved forecast of climate adaptation and managing future biodiversity and fisheries species through resilient genes and populations.Read moreRead less
A Varied Diet, Ageing, and the Evolution of Life Histories. This research aims to understand how nutritional environments affect lifespan and its evolution. The expected outcomes are improved knowledge around the biology of ageing including the identification of diet-responsive genes and biological pathways. These elements will comprise targets for future applied studies on ageing, metabolic dysfunction and personalised nutrition. This study will also inform as to how lifespans evolve. Because l ....A Varied Diet, Ageing, and the Evolution of Life Histories. This research aims to understand how nutritional environments affect lifespan and its evolution. The expected outcomes are improved knowledge around the biology of ageing including the identification of diet-responsive genes and biological pathways. These elements will comprise targets for future applied studies on ageing, metabolic dysfunction and personalised nutrition. This study will also inform as to how lifespans evolve. Because lifespan is a fundamental demographic trait, this knowledge will improve ability to predict how populations adapt to environmental change. Lastly, through methodological innovation this project will also provide new statistical tools for studying how treatments affect the risk of death age specifically.Read moreRead less
An integrated mechanistic model of species' responses to environmental change: from individual responses to range shifts and beyond. To effectively adapt to future environmental change, reliable forecasts are needed of how human alterations to climate and habitat will affect species. This project integrates cutting-edge methods in nutritional, physiological and spatial ecology to develop new tools for predicting and understanding how species will respond to environmental change.
The failure-threshold of leaves in drought. This project aims to reveal how specific water-stress thresholds damage the leaves of Australian crop and forest species during drought. Water stress affects agricultural productivity and plant survival in drought-prone regions such as Australia. Using optical and X-ray techniques, this project seeks to visualise and quantify the dynamic processes of damage and repair in leaves under stress. Anticipated outputs include a practical basis to predict drou ....The failure-threshold of leaves in drought. This project aims to reveal how specific water-stress thresholds damage the leaves of Australian crop and forest species during drought. Water stress affects agricultural productivity and plant survival in drought-prone regions such as Australia. Using optical and X-ray techniques, this project seeks to visualise and quantify the dynamic processes of damage and repair in leaves under stress. Anticipated outputs include a practical basis to predict drought-induced canopy death; identification of threats to ecologically sensitive plants; and selection and screening tools to improve the drought resilience of agriculturally important crop species.Read moreRead less