Development Of An Antibody-targeted Drug/miRNA/peptide Delivery System For Effective Prevention Of Restenosis
Funder
National Health and Medical Research Council
Funding Amount
$319,064.00
Summary
The re-blocking of vessels after surgery occurs up to 50% of patients, and none of the preventive approaches are cost-effective and safe enough. This project aims to develop a nano-scaled therapeutics delivering combination therapies to effectively prevent the re-blockage after surgery. If successful, this research will present a whole new range of therapeutic agent that prevents the patient from developing clots after surgery, improving the productivity and health of patients with reduced cost.
Prevention Of Stroke Caused By Carotid Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$200,062.00
Summary
Stroke is a leading cause of death and disability and a huge drain on health resources in Australia and worldwide. Carotid artery atherosclerosis (vascular disease) is an important cause of stroke. Currently surgery (with a significant risk of stroke-death) is commonly performed to prevent carotid stroke. My aim is to show that current best practice medical intervention is superior to surgery and to identify high risk patients for whom additional stroke prevention strategies may be justified.
Studying Coronary Physiology Within Human Coronary Arteries Using Computational Fluid Dynamics
Funder
National Health and Medical Research Council
Funding Amount
$383,834.00
Summary
The aim of this project is to combine the recent technological advances within the individual fields of coronary physiology, three-dimensional coronary angiography, and computational fluid dynamics to develop a novel method to calculate realistic coronary blood flow. This technique will provide a simple and clinically applicable method to measure physiological parameters such as microcirculatory resistance and shear stress within _live� human coronary arteries.
An International Population-Based Study Into The Genetic Epidemiology Of Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Melanoma is the most aggressive form of skin cancer and is a major public health issue in Australia. This project aims to find genes and levels of sun exposure, plus ways the genes and exposure interact with each other, that increase people’s risk of melanoma and how long they survive after diagnosis. The results will help to identify people at a higher risk of disease earlier and also better predict prognosis in those already diagnosed.
Evaluating Coronary Stents Using High-resolution Optical Coherence Tomography Imaging In Patients With Coronary Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$217,274.00
Summary
A stent is a device made of metal that is placed inside an artery to prop it. Recently, the applicant introduced into Australia a novel technology to examine these stents once inside the body. This information may help make stents safer for patients
Plasma Metabolomic Profiling Of Patients With Serial Coronary Atheroma Progression For Predicting Myocardial Infarction And Death
Funder
National Health and Medical Research Council
Funding Amount
$373,114.00
Summary
Heart attacks are the leading cause of death, and half of all 1st heart attack victims have </= 1 known risk factors for coronary heart disease. There is an urgent need to better predict heart attack risk, and to develop new drugs to combat atherosclerosis. This study will involve a more advanced technique of identifying new molecules found in people who demonstrate progression of coronary atherosclerosis, heart attack and death, in the setting of a large-scale clinical trial testing a new ag ....Heart attacks are the leading cause of death, and half of all 1st heart attack victims have </= 1 known risk factors for coronary heart disease. There is an urgent need to better predict heart attack risk, and to develop new drugs to combat atherosclerosis. This study will involve a more advanced technique of identifying new molecules found in people who demonstrate progression of coronary atherosclerosis, heart attack and death, in the setting of a large-scale clinical trial testing a new agent that dramatically lowers cholesterol.Read moreRead less