Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Engineering improved and multifunctional gene editing systems. Advances in genome editing have enabled the targeted modulation of gene expression in cells and provided new tools for biotechnology. This project will combine computational design and genetic selection to deliver the next generation of precision gene editing tools. These new technologies can be used for modification of genes in any cellular compartment and will be useful for understanding and improving energy metabolism. Increased c ....Engineering improved and multifunctional gene editing systems. Advances in genome editing have enabled the targeted modulation of gene expression in cells and provided new tools for biotechnology. This project will combine computational design and genetic selection to deliver the next generation of precision gene editing tools. These new technologies can be used for modification of genes in any cellular compartment and will be useful for understanding and improving energy metabolism. Increased cellular energy production can be harnessed to make valuable biological products, with unprecedented efficiency.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100714
Funder
Australian Research Council
Funding Amount
$354,000.00
Summary
Shaping light – new frontiers in big fast data. This project aims to address the need for new technologies to tackle the bandwidth overload. Because of the basic human desire to communicate and interact, our society has an exponentially growing Internet data demand. The data capacity crunch is imminent. Data demand is rapidly approaching the nonlinear Shannon limit which governs the maximum data capacity of single-mode optical fibres. Bandwidth limitations may have severe implications for societ ....Shaping light – new frontiers in big fast data. This project aims to address the need for new technologies to tackle the bandwidth overload. Because of the basic human desire to communicate and interact, our society has an exponentially growing Internet data demand. The data capacity crunch is imminent. Data demand is rapidly approaching the nonlinear Shannon limit which governs the maximum data capacity of single-mode optical fibres. Bandwidth limitations may have severe implications for society and economy. This project aims to develop chip-scale mode-multiplexers based on innovative 3D integrated photonics and combine them with optical gain to shape light for space-division multiplexed optical communication networks. This is designed to break through the data capacity limit that currently prevents growth in Internet data rates.Read moreRead less
Towards an intercontinental quantum network. This project aims to address the security vulnerabilities of online data transmission. Cyber attacks and data stealing are threatening the daily operations of public and private organisations worldwide, and the privacy of individuals. This project expect to realise the key element for a new global network architecture where security is guaranteed by the fundamental laws of physics. This element is the quantum node and it will be implemented through th ....Towards an intercontinental quantum network. This project aims to address the security vulnerabilities of online data transmission. Cyber attacks and data stealing are threatening the daily operations of public and private organisations worldwide, and the privacy of individuals. This project expect to realise the key element for a new global network architecture where security is guaranteed by the fundamental laws of physics. This element is the quantum node and it will be implemented through the development of new techniques for the control and manipulation of individual atoms and innovative integrated optical devices for the interface with fibre networks. The development of this technology will lead to intrinsically secure online communication for organisations in the health and defence sectors and private individuals worldwide.Read moreRead less
Routing shapes of light for the next generation of fibre optic networks. In 2016, the United Nations declared access to the Internet as basic human right. Our communication networks are facing a capacity crunch, which will transform a basic human right for everyone into a privilege for a few. This project aims to avoid a capacity crunch by creating innovative solutions for the next generation of optical fibre communication networks. This project stands to generate new knowledge in photonics, opt ....Routing shapes of light for the next generation of fibre optic networks. In 2016, the United Nations declared access to the Internet as basic human right. Our communication networks are facing a capacity crunch, which will transform a basic human right for everyone into a privilege for a few. This project aims to avoid a capacity crunch by creating innovative solutions for the next generation of optical fibre communication networks. This project stands to generate new knowledge in photonics, optical communication and advanced manufacturing. The expected benefits are new academic collaborations, enhancing Australia’s international standing and economic benefit through commercialisation and training of students for the growing photonics industry in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100055
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Controlling light with nonlinear effects in silicon nanocrystals. The project will help to promote in Australia the novel field of silicon nanophotonics, which is currently one of the most explored disciplines within the field of integrated optics. It will introduce innovative concepts for superior light control, which will keep Australia at the forefront of international research and frontier technologies.
Discovery Early Career Researcher Award - Grant ID: DE150100091
Funder
Australian Research Council
Funding Amount
$341,000.00
Summary
Traffic on DNA: interplay between RNA polymerases and DNA-bound proteins. The DNA inside the cell is not just a repository of information, but is an active player in how that information is used. Proteins bind to defined locations on the DNA to control which genes are active, and genes are expressed by RNA polymerases that track along the DNA. Collisions between RNA polymerases and DNA-bound proteins can remove the proteins or block the polymerase. How can these essential processes safely coexis ....Traffic on DNA: interplay between RNA polymerases and DNA-bound proteins. The DNA inside the cell is not just a repository of information, but is an active player in how that information is used. Proteins bind to defined locations on the DNA to control which genes are active, and genes are expressed by RNA polymerases that track along the DNA. Collisions between RNA polymerases and DNA-bound proteins can remove the proteins or block the polymerase. How can these essential processes safely coexist on the DNA? The project aims to integrate systematic experiments using well-defined genetic components and mathematical modelling to understand the 'design' features of DNA and proteins that minimise these traffic problems. A better understanding could inform new strategies for manipulation of gene expression.Read moreRead less
Structural domains of beta-tubulin and their role in microtubule dynamics and transport. This study aims to obtain a fundamental understanding of how the structural domains of the cytoskeletal protein beta-tubulin are involved in microtubule structures during cell division and vesicular transport. Using gene-editing technology and coupling this with cell biological approaches and high-resolution cell imaging will enable detailed analysis of the role of beta-tubulin domains in these important cel ....Structural domains of beta-tubulin and their role in microtubule dynamics and transport. This study aims to obtain a fundamental understanding of how the structural domains of the cytoskeletal protein beta-tubulin are involved in microtubule structures during cell division and vesicular transport. Using gene-editing technology and coupling this with cell biological approaches and high-resolution cell imaging will enable detailed analysis of the role of beta-tubulin domains in these important cellular processes. The outcomes will include fundamental new knowledge in cell biology and lead to the development of unique biological models that can be used to understand disease.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100620
Funder
Australian Research Council
Funding Amount
$378,000.00
Summary
Mechanisms of controlled gene expression in cells and organisms. The goal of this project is to reveal the nature of a cellular mechanism that has a major influence on gene expression in all eukaryotic cells. How gene expression is controlled is of fundamental importance to all life forms. The project plans to develop molecular tools that enable the visualisation and interrogation of this gene regulatory mechanism in live cells, tissues and whole organisms. The outcomes are anticipated to lead t ....Mechanisms of controlled gene expression in cells and organisms. The goal of this project is to reveal the nature of a cellular mechanism that has a major influence on gene expression in all eukaryotic cells. How gene expression is controlled is of fundamental importance to all life forms. The project plans to develop molecular tools that enable the visualisation and interrogation of this gene regulatory mechanism in live cells, tissues and whole organisms. The outcomes are anticipated to lead to an essential understanding of how cells respond to physiological and environmental cues by coordinating changes in gene expression, and to provide potential avenues towards manipulation for pharmaceutical, agricultural and biotechnology purposes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101669
Funder
Australian Research Council
Funding Amount
$430,485.00
Summary
Polycomb Group Proteins - Shaping Chromatin Architecture to Silence Genes . This project aims to address the fundamental question of how genes are switched off by studying a group of molecular off-switches, the polycomb group proteins. The project is expected to generate new knowledge in the area of gene regulation and epigenetics by combining innovative methods of structural biology and cell biology in an interdisciplinary way. The expected outcomes include a more complete picture of the molecu ....Polycomb Group Proteins - Shaping Chromatin Architecture to Silence Genes . This project aims to address the fundamental question of how genes are switched off by studying a group of molecular off-switches, the polycomb group proteins. The project is expected to generate new knowledge in the area of gene regulation and epigenetics by combining innovative methods of structural biology and cell biology in an interdisciplinary way. The expected outcomes include a more complete picture of the molecular mechanisms that regulate gene expression and the development of novel methods to image the genome. This should provide significant benefits, such as facilitated development of gene editing tools and regulatory circuits for synthetic biology, as well as novel capabilities to image the genome at high resolution Read moreRead less