Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Eat, cook, grow: Ubiquitous technology for sustainable food culture in the city. Raising people's awareness of healthy and ecological food options with nutritional data and educational information does not foster a sustained practice towards a more environmentally friendly food culture. This study seeks to develop a better understanding how to go beyond just informing and into supporting and sustaining action and change. Drawing on interaction design, ubiquitous computing and real- time informat ....Eat, cook, grow: Ubiquitous technology for sustainable food culture in the city. Raising people's awareness of healthy and ecological food options with nutritional data and educational information does not foster a sustained practice towards a more environmentally friendly food culture. This study seeks to develop a better understanding how to go beyond just informing and into supporting and sustaining action and change. Drawing on interaction design, ubiquitous computing and real- time information, the study will deliver research findings that inform viable new design approaches and information interfaces which will strengthen Australia's position to resolve the problems of obesity, malnutrition and ecological issues of mass food processing, and contribute to the sustainability of life in Australian cities.Read moreRead less
Sociophysical Interactions: understanding the role of social and tangible technologies in maintaining good habits into old age. How can technology help us 'age well'? The project will study, design and evaluate novel information systems that integrate and support social engagement and physical activity in order to build foundational knowledge about these technologies and maintain the opportunities for social engagement and physical activity in our ageing population.
Enhancing the content and experience of Interactive Childrens Television. Interactive television (iTV) as a participatory, on-demand communication provides a unique opportunity to significantly engage, entertain and educate preschool children. Through considerable industry partner collaboration and participation, this project will evaluate three distinct interactive options produced from selected children's television programs with proven success in Australia. Usability studies employing a vari ....Enhancing the content and experience of Interactive Childrens Television. Interactive television (iTV) as a participatory, on-demand communication provides a unique opportunity to significantly engage, entertain and educate preschool children. Through considerable industry partner collaboration and participation, this project will evaluate three distinct interactive options produced from selected children's television programs with proven success in Australia. Usability studies employing a variety of surveillance techniques will evaluate content design and user response. Children's viewing habits will be evaluated within a social context (the home) and a mobile lab setting using qualitative and quantitative assessment. The results will identify effective ways to produce meaningful interactivity and will encourage future industry based research.Read moreRead less
Framing and Enabling Children’s Active Play using Novel Technology. This project aims to address inactivity in the 3-5 age group through understanding and exploring innovative interactive active play experiences for children, with a view to increasing their physical activity over the long term. This project will be based on empirical research with real children undertaking real interactive experiences in real contexts, in order to understand issues around sustained engagement with these types of ....Framing and Enabling Children’s Active Play using Novel Technology. This project aims to address inactivity in the 3-5 age group through understanding and exploring innovative interactive active play experiences for children, with a view to increasing their physical activity over the long term. This project will be based on empirical research with real children undertaking real interactive experiences in real contexts, in order to understand issues around sustained engagement with these types of systems. We will design and develop solutions that may address the issues and test those interventions in a longitudinal manner. The outcome will be a framework which can be applied in a variety of situations and modalities by designers and developers of such systems, and feed into childhood technology guidelines.
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Special Research Initiatives - Grant ID: SR0354753
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
MESH: amalgamating innovative teams of cross-disciplinary collaborators for creativity in Media-arts, E-culture, Science and Humanities. MESH is a cross-disciplinary network that amalgamates a national array of sub-networks of research in digital arts, ICT and cross-cultural and policy negotiation. It boosts Australia's existing cross-disiciplinary strengths in Media-arts, E-culture, Science and Humanities by encouraging existing digital sub-networks to grow together via well-brokered communic ....MESH: amalgamating innovative teams of cross-disciplinary collaborators for creativity in Media-arts, E-culture, Science and Humanities. MESH is a cross-disciplinary network that amalgamates a national array of sub-networks of research in digital arts, ICT and cross-cultural and policy negotiation. It boosts Australia's existing cross-disiciplinary strengths in Media-arts, E-culture, Science and Humanities by encouraging existing digital sub-networks to grow together via well-brokered communications and demonstrations online and on-location. Progressively, MESH participants will discover existing harmonies whilst also inventing new languages and protocols leading to breakthroughs in cross-disciplinary collaboration and innovation. MESH encourages a 'paradigm shift' in digital research, realising the extraordinary potential that is ready but latent across Australia's arts and sciences.Read moreRead less
Investigating Post-transcriptional Gene Regulation In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
In this program, I will enhance our understanding of cancer gene regulation and provide novel avenues for the treatment of aggressive tumours. Using own data and that from collaborators, I will determine patterns of gene regulation in blood cancers and identify markers that predict disease outcome. I aim to understand how gene regulation can transform healthy cells into tumour cells and whether personalised treatment can kill tumour cells more effectively and prevent relapse and metastasis.
Transforming The Diagnosis And Management Of Severe Neurocognitive Disorders Through Genomics
Funder
National Health and Medical Research Council
Funding Amount
$2,499,330.00
Summary
Neurocognitive disorders (NCD) are one of the most common genetic conditions in our society and it results with a need for ongoing permanent care for many affected people. Until recently, only 30% of people with NCD could be diagnosed but this has changed with the availability of genomic testing where all genes can be tested at once. The use of genomics in the CRE will lead to new NCD genes being identified and this information being translated into a clinical setting.