A new theory for retinotectal map formation. How brains become wired up during development is a question of
importance to both biology and computing. In this project we adopt a
novel computational approach to understanding the development of
topographic maps, a wiring pattern that is ubiquitous in biological
nervous systems. This project will build capacity for research in
computational neuroscience in Australia. It may also lead to
technological benefits such as new ideas for the design o ....A new theory for retinotectal map formation. How brains become wired up during development is a question of
importance to both biology and computing. In this project we adopt a
novel computational approach to understanding the development of
topographic maps, a wiring pattern that is ubiquitous in biological
nervous systems. This project will build capacity for research in
computational neuroscience in Australia. It may also lead to
technological benefits such as new ideas for the design of self-wiring
computing devices, and new insights into
the causes of wiring defects both during normal development and
rewiring after injury.
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Wiring up the nervous system: how do axons detect molecular gradients? This project will improve our understanding of how the nervous system
becomes wired up during development. This will ultimately allow better
therapies for some types of developmental disorders, and for repairing
damaged connections for instance in the spinal cord. The theoretical
models developed will improve our understanding of the computations
necessary to generate appropriate wiring of the nervous system, which
may ....Wiring up the nervous system: how do axons detect molecular gradients? This project will improve our understanding of how the nervous system
becomes wired up during development. This will ultimately allow better
therapies for some types of developmental disorders, and for repairing
damaged connections for instance in the spinal cord. The theoretical
models developed will improve our understanding of the computations
necessary to generate appropriate wiring of the nervous system, which
may facilitate the development of self-organizing computing
devices. The project will also provide unique research training at the
interface of biology and computation, building capacity for such
interdisciplinary research throughout Australia.
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Systems biology to integrate genomics into crop improvement programs. Plant breeding programs have not reaped the benefits of the revolution in molecular genetic technologies. This systems biology project will develop mathematical models of plants to span levels of biological organisation from gene to whole organism. It will focus on understanding and modelling the genetics and physiology of key adaptive traits in sorghum and maize. It will use computer simulation to employ resultant gene-to- ....Systems biology to integrate genomics into crop improvement programs. Plant breeding programs have not reaped the benefits of the revolution in molecular genetic technologies. This systems biology project will develop mathematical models of plants to span levels of biological organisation from gene to whole organism. It will focus on understanding and modelling the genetics and physiology of key adaptive traits in sorghum and maize. It will use computer simulation to employ resultant gene-to-phenotype models in ways that will underpin a major shift in how plant breeding programs operate. This new integrating technology will lead to more rapid advance in breeding better adapted and higher yielding crops.Read moreRead less