Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Industrial Transformation Training Centres - Grant ID: IC230100015
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation ....ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation of infrastructure design in Australia and internationally. Achieving carbon neutral infrastructure in its whole life will bring significant far-reaching benefits, including equipping industry with tools required to meet Australia’s emission reduction targets as well as economic, commercial, environmental, and social gains.Read moreRead less
Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We ....Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We will generate antibody fragments that bind these MP and express them in tomato. We will analyse antibody expression in tomato and study their association with the phytoplasma membrane. Transgenic plants will be inoculated with phytoplasma and monitored for resistance. This work represents a major step towards engineering resistance to phytoplasmas.Read moreRead less
Using community engagement and enhanced visual information to promote FireWatch satellite communication as a support for collaborative decision-making. Using continuously updated satellite data, FireWatch will repurpose its professional service for use by the wider public, informing community-based decision-making and action. Communication flows and community decision-making will promote informed action at times of fire stress. Complex visual data will be communicated in clear and compelling way ....Using community engagement and enhanced visual information to promote FireWatch satellite communication as a support for collaborative decision-making. Using continuously updated satellite data, FireWatch will repurpose its professional service for use by the wider public, informing community-based decision-making and action. Communication flows and community decision-making will promote informed action at times of fire stress. Complex visual data will be communicated in clear and compelling ways.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100278
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
Automating the smart home: an investigation of automated cooling practices. Home automation technologies are expected to achieve reductions in household energy costs and consumption. However, there has been no systematic investigation of the ways in which they are being incorporated into everyday life. The project aims to address this critical gap in relation to home cooling. It will investigate how automated cooling technologies are being incorporated into household practices in Australia, and ....Automating the smart home: an investigation of automated cooling practices. Home automation technologies are expected to achieve reductions in household energy costs and consumption. However, there has been no systematic investigation of the ways in which they are being incorporated into everyday life. The project aims to address this critical gap in relation to home cooling. It will investigate how automated cooling technologies are being incorporated into household practices in Australia, and the expectations they promote, sustain and transform. The project also aims to produce important new knowledge about how to study and understand the effects of ambient and automated technologies in everyday life and their potential impact on energy consumption.Read moreRead less
Adverse effects of sopite syndrome on occupants in wind-excited buildings. Current building motion design guidelines focus primarily on motion perception and complaint rates. However, wind-induced building motion can cause sopite syndrome or early onset motion sickness which adversely affects occupant wellbeing and work performance. This research aims to advance the understanding of the physiology of sopite syndrome, quantify the motion dosage that causes sopite syndrome and determine its advers ....Adverse effects of sopite syndrome on occupants in wind-excited buildings. Current building motion design guidelines focus primarily on motion perception and complaint rates. However, wind-induced building motion can cause sopite syndrome or early onset motion sickness which adversely affects occupant wellbeing and work performance. This research aims to advance the understanding of the physiology of sopite syndrome, quantify the motion dosage that causes sopite syndrome and determine its adverse effects on building occupants in real-world motion environments. This knowledge is expected to guide the formulation of building motion acceptability criteria based on safe motion exposure duration to facilitate the design of tall building that promotes population health and wellbeing and lifts work performance and productivity.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989804
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A Universal Nano Tribometer for Surface and Thin Film Characterisation. The proposed infrastructure will be of major benefit to a large number of ARC funded research projects involving chracterisation of materials at four universities UOW,QUT, UNSW and CDU. The project will extend the research capability of the participating researchers and facilitate innovative projects and new research direction in advanced materials processing in the nano/micro scale. This in turn will lead to improved intern ....A Universal Nano Tribometer for Surface and Thin Film Characterisation. The proposed infrastructure will be of major benefit to a large number of ARC funded research projects involving chracterisation of materials at four universities UOW,QUT, UNSW and CDU. The project will extend the research capability of the participating researchers and facilitate innovative projects and new research direction in advanced materials processing in the nano/micro scale. This in turn will lead to improved international competitiveness of Australian industry.Read moreRead less
ABRA: improving foundational literacy through technology in regional and remote schools through a randomized controlled trial. Education outcomes in regional and remote Australia, particularly for Indigenous students, are worsening, to the point of constituting a national crisis. Skilled educators are not consistently available in sufficient numbers to arrest this trend in the early years by giving the intensive, continuous expert instruction required. Under limited pilot conditions, a web-base ....ABRA: improving foundational literacy through technology in regional and remote schools through a randomized controlled trial. Education outcomes in regional and remote Australia, particularly for Indigenous students, are worsening, to the point of constituting a national crisis. Skilled educators are not consistently available in sufficient numbers to arrest this trend in the early years by giving the intensive, continuous expert instruction required. Under limited pilot conditions, a web-based instructional tool known as ABRACADABRA has shown considerable promise as a means of conferring the foundational skills in literacy for emerging learners, despite high workforce turnover. Testing the effectiveness of ABRACADABRA under more stringent experimental conditions is an essential precursor to offering tested solutions based on evidence, not advocacy.Read moreRead less
Caring for Cosmologies: Making Living Maps for West Miyarrka. This project aims to develop a new kind of digital mapping to document endangered forms of knowledge along a coastline under threat from climate change. The project expects to draw on unique Yolngu knowledge practices and representational systems - with traditional owners and managers guiding digital media experts, rangers and artists. Expected outcomes include: 1) expanded Indigenous research capacities and digital expertise; and, 2) ....Caring for Cosmologies: Making Living Maps for West Miyarrka. This project aims to develop a new kind of digital mapping to document endangered forms of knowledge along a coastline under threat from climate change. The project expects to draw on unique Yolngu knowledge practices and representational systems - with traditional owners and managers guiding digital media experts, rangers and artists. Expected outcomes include: 1) expanded Indigenous research capacities and digital expertise; and, 2) access to novel resources for a new generation of Indigenous leaders. Benefits include: enhanced intergenerational and intercultural knowledge transmission and negotiation; methods adaptable to other Indigenous contexts; and greater national recognition of Indigenous seeing and caring for country.Read moreRead less