Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We ....Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We will generate antibody fragments that bind these MP and express them in tomato. We will analyse antibody expression in tomato and study their association with the phytoplasma membrane. Transgenic plants will be inoculated with phytoplasma and monitored for resistance. This work represents a major step towards engineering resistance to phytoplasmas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less
Special Research Initiatives - Grant ID: SR120300015
Funder
Australian Research Council
Funding Amount
$16,000,000.00
Summary
The Science of Learning Research Centre. In this innovative new Centre, researchers in education, neuroscience and cognitive psychology will work together with teachers to understand the learning process. This collaboration will establish new criteria to assess the impact of different types of learning and strategies to inform teaching practices of benefit to all Australians.
Thermodynamics inversion for mineral systems. This project aims to provide a newly developed science approach to the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP). AusLAMP provides unparalleled geophysical information aimed at unravelling the tectonic history of the Australian continent and its mineral potential. The project will use thermodynamically based geodynamic simulators to jointly analyse and quantify intraplate deformation. This will illuminate the cause of dri ....Thermodynamics inversion for mineral systems. This project aims to provide a newly developed science approach to the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP). AusLAMP provides unparalleled geophysical information aimed at unravelling the tectonic history of the Australian continent and its mineral potential. The project will use thermodynamically based geodynamic simulators to jointly analyse and quantify intraplate deformation. This will illuminate the cause of driving fluid flow thorough the lithosphere, mineralisation phenomena, their datasets and geometries, and dynamic aspects of the processes driving mineral systems.Read moreRead less
Dating the aboriginal rock art sequence of the Kimberley in north west Australia. This project aims to develop a robust time scale for the known aboriginal rock art sequence in the Kimberley, Western Australia (WA). The project will use new knowledge of complex processes on sandstone surfaces across the north Kimberley, and an innovative combination of four scientific dating methods developed through our earlier work. The project expects to provide a well-dated sequence for Kimberley rock art ba ....Dating the aboriginal rock art sequence of the Kimberley in north west Australia. This project aims to develop a robust time scale for the known aboriginal rock art sequence in the Kimberley, Western Australia (WA). The project will use new knowledge of complex processes on sandstone surfaces across the north Kimberley, and an innovative combination of four scientific dating methods developed through our earlier work. The project expects to provide a well-dated sequence for Kimberley rock art based on replication of results, confirmation across different methods, and a large interdisciplinary data set. The project will allow rigorous analysis of the relationship between dating results and rock art styles that has not previously been possible, and give new insights into Australia’s deep indigenous heritage. This will have a significant impact for future efforts in rock art conservation, and lay a foundation for cultural tourism, with important benefits for the local economy and health of regional indigenous communities.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100015
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation ....ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation of infrastructure design in Australia and internationally. Achieving carbon neutral infrastructure in its whole life will bring significant far-reaching benefits, including equipping industry with tools required to meet Australia’s emission reduction targets as well as economic, commercial, environmental, and social gains.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100117
Funder
Australian Research Council
Funding Amount
$1,275,000.00
Summary
A platform consortium for integrated 'systems-omics' research. The proposal aims to establish a multi-institutional integrated ‘systems-omics’ platform across two of Victoria’s leading research universities, and associated research institutes. The platform will consist of two cutting edge ultra-high resolution mass spectrometers (i) a Thermo Scientific Orbitrap Fusion LUMOS for rapid and comprehensive metabolomic profiling and detailed structural characterization, located at La Trobe University ....A platform consortium for integrated 'systems-omics' research. The proposal aims to establish a multi-institutional integrated ‘systems-omics’ platform across two of Victoria’s leading research universities, and associated research institutes. The platform will consist of two cutting edge ultra-high resolution mass spectrometers (i) a Thermo Scientific Orbitrap Fusion LUMOS for rapid and comprehensive metabolomic profiling and detailed structural characterization, located at La Trobe University, and (ii) a Thermo Scientific Orbitrap Q Exactive HFX for high-throughput, deep and reproducible quantitative proteome analysis, located at the University of Melbourne.This platform will address applications across the agri-biosciences, medicinal agriculture and fundamental biomedical sciences sectors.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100159
Funder
Australian Research Council
Funding Amount
$160,000.00
Summary
Mobile Australian field isotope alliance. This project will enable a quantum leap in capacity to undertake, real-time, field-based studies of environmental processes using the natural isotope tracers of carbon, oxygen and hydrogen. This will enable the project to address a range of fundamental research questions in climate change, water resources, ecology and human impact in tropical Australia.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100063
Funder
Australian Research Council
Funding Amount
$539,000.00
Summary
A Living Archive of Aboriginal Languages - Stage II. A living archive of Aboriginal languages - Stage 2: A living archive of 16 Australian Indigenous languages was created with funding from an ARC 2012 LIEF grant. This project for Stage 2 aims to involve more partner organisations to radically expand the number of languages and document types included, to develop bespoke interfaces and technical configurations at the remote community level, and to engage local language authorities, community mem ....A Living Archive of Aboriginal Languages - Stage II. A living archive of Aboriginal languages - Stage 2: A living archive of 16 Australian Indigenous languages was created with funding from an ARC 2012 LIEF grant. This project for Stage 2 aims to involve more partner organisations to radically expand the number of languages and document types included, to develop bespoke interfaces and technical configurations at the remote community level, and to engage local language authorities, community members and school students to work with researchers around the world in refining and extending the archive. Read moreRead less