The Role Of The Transcription Factor IRF4 In Peripheral Cd8 T Cell Differentiation
Funder
National Health and Medical Research Council
Funding Amount
$399,176.00
Summary
T cells protect against viral infections and fight cancer cells. In order to fulfill these roles T cells have to undergo significant phenotypic and functional changes. Our preliminary data indicate a central role for the regulator protein IRF4 in this process, as T cells that lack this protein are unable to grow and acquire the cellular tools necessary to provide protection. We wish to characterize the role of IRF4 in T cells in detail and aim to identify the processes regulated by IRF4.