A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
Understanding The Causes Of Childhood Congenital Anomalies Of The Kidney And Urinary Tract
Funder
National Health and Medical Research Council
Funding Amount
$609,748.00
Summary
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified ....Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified genes.Read moreRead less
Thermal enhancement strategies and development of a high-performance micro-scale heat exchanger for thermoelectric refrigeration with large cooling loads. Traditional refrigeration essentially utilises CFC-refrigerants which are potent atmospheric pollutants causing widespread ecological damage. Devoid of such adversities, electronic heat pumping mechanism of thermoelectric principle offers a practical ?CFC-free? alternative for conventional cooling methods. While the current thermoelectric te ....Thermal enhancement strategies and development of a high-performance micro-scale heat exchanger for thermoelectric refrigeration with large cooling loads. Traditional refrigeration essentially utilises CFC-refrigerants which are potent atmospheric pollutants causing widespread ecological damage. Devoid of such adversities, electronic heat pumping mechanism of thermoelectric principle offers a practical ?CFC-free? alternative for conventional cooling methods. While the current thermoelectric technology adequately meets light cooling demand, its potential for heavy-duty refrigeration is critically undermined by ill-developed methods for dissipating heat from thermoelectric modules to coolants, and remains grossly under-utilised. The proposed work will devise novel heat transfer techniques for raising thermoelectric cooling thresholds to suit large heat loads and develop a thermally enhanced micro-scale heat exchanger for application in commercial thermoelectric refrigeration.Read moreRead less
Transcriptional Control Of Blood Vessel Development By Sox18
Funder
National Health and Medical Research Council
Funding Amount
$468,564.00
Summary
Blood vessels play an essential role in maintaining the supply of nutrients to every organ and tissue in the body. Improper development of blood vessels in the embryo can compromise survival of the embryo, and defects in the ability of blood vessels to grow, regenerate and adapt to change during adult life can be life-threatening. The growth of new blood vessels (angiogenesis) is also an important factor in the ability of solid tumours to grow during the progression of cancer. It is therefore of ....Blood vessels play an essential role in maintaining the supply of nutrients to every organ and tissue in the body. Improper development of blood vessels in the embryo can compromise survival of the embryo, and defects in the ability of blood vessels to grow, regenerate and adapt to change during adult life can be life-threatening. The growth of new blood vessels (angiogenesis) is also an important factor in the ability of solid tumours to grow during the progression of cancer. It is therefore of fundamental importance in the health sciences to gain an understanding of how blood vessels form and regenerate. As a result of our collaborative research efforts, we have discovered a gene, Sox18, that appears to regulate blood vessel development by controlling the formation and-or behaviour of endothelial cells, which line the blood vessels and make them impermeable. Our research so far indicates that MICE WITH DEFECTS IN SOX18 DIE FROM VASCULAR DEFECTS, underlining the importance of this gene. THIS PROJECT IS CONCERNED WITH FINDING OUT HOW SOX18 WORKS - exactly what goes wrong in mice lacking this gene, whether Sox18 can influence endothelial cell behaviour in cell culture, how Sox18 comes to be active in endothelial cells, what genes are switched on by Sox18, and what genes Sox18 co-operates with in its role in endothelial cells. The answers to these questions will not only provide fundamental basic information about how blood vessels development is controlled, but also sow the seeds for possible future therapies in which blood vessel development could be stimulated (eg in wound healing) or suppressed (eg in tumour progression) through pharmaceutical intervention.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101533
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
A risk-based approach to natural gas hydrates in oil and gas production. Like a cholesterol for oil and gas pipelines, gas hydrates are ice-like deposits that completely block the flow during production and are expensive to prevent as well as dangerous to remove. This proposal provides a risk-based approach to hydrate management that will increase the viability of natural gas production from fields in deep water.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100174
Funder
Australian Research Council
Funding Amount
$193,000.00
Summary
Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be i ....Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be integrated with a specialised Raman imaging microscope to study crystallisation, mass transfer and molecular exchange, in application areas including energy transport, carbon capture and storage, and protein nucleation. This project is expected to open new avenues in engineering, chemistry and physics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101094
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Precision Spectroscopy of CO2 Exchange in Hydrates for Clean Energy Production. Carbon dioxide capture and sequestration is a widely considered climate change mitigation strategy. Clathrate hydrates of natural gas, found in deep-water ocean sediments, represent a tremendous opportunity for simultaneous carbon dioxide sequestration and clean energy production. By injecting carbon dioxide into the hydrate reservoir, methane can be displaced and replaced by carbon dioxide. This project will use Ram ....Precision Spectroscopy of CO2 Exchange in Hydrates for Clean Energy Production. Carbon dioxide capture and sequestration is a widely considered climate change mitigation strategy. Clathrate hydrates of natural gas, found in deep-water ocean sediments, represent a tremendous opportunity for simultaneous carbon dioxide sequestration and clean energy production. By injecting carbon dioxide into the hydrate reservoir, methane can be displaced and replaced by carbon dioxide. This project will use Raman spectroscopy and nuclear magnetic resonance imaged core-flood experiments to develop a fundamental understanding of the exchange mechanisms governing the replacement of the methane molecule in the hydrate cage with carbon dioxide. This knowledge will be critical for future development of these resources to safely extract methane from sub-sea hydrates.Read moreRead less
Heat Transfer Mechanisms in an Indirectly Fired Rotary Kiln with Lifters and Its Role in Scaling. This project will apply heat transfer principles to improve and optimise the design and performance of ANSAC's innovative kiln technology for a wide range of process applications. By understanding the mechanisms of heat transfer involved in the working of the proprietary technology, major factors limiting the performance of the kiln can be identified, resulting in design criteria that link key opera ....Heat Transfer Mechanisms in an Indirectly Fired Rotary Kiln with Lifters and Its Role in Scaling. This project will apply heat transfer principles to improve and optimise the design and performance of ANSAC's innovative kiln technology for a wide range of process applications. By understanding the mechanisms of heat transfer involved in the working of the proprietary technology, major factors limiting the performance of the kiln can be identified, resulting in design criteria that link key operating parameters for the kiln scaling and performance forecast. The research outcomes will provide a scientific basis that underpins the development of an Australian technology and supports the growth of a new Australian small business, creating employment opportunities within Australia.Read moreRead less
Near zero-emission hydrogen and carbon production from natural gas and bio-methane. Hydrogen is envisaged as a clean fuel for power generation particularly for the transportation sector. In the short- and mid-term future, hydrogen will be derived from fossil fuels. Based on the conventional processes, the route from fossil fuels to hydrogen invariably produces greenhouse gases. Geosequestration is a viable technique of storing carbon dioxide but has an uncertain long-term environmental ramifi ....Near zero-emission hydrogen and carbon production from natural gas and bio-methane. Hydrogen is envisaged as a clean fuel for power generation particularly for the transportation sector. In the short- and mid-term future, hydrogen will be derived from fossil fuels. Based on the conventional processes, the route from fossil fuels to hydrogen invariably produces greenhouse gases. Geosequestration is a viable technique of storing carbon dioxide but has an uncertain long-term environmental ramification. In contrast, our proposed technique avoids the production of greenhouse gases and, instead, engenders high value added graphitized carbon as a by-product. Given the relative stability and value of graphitized carbon, our catalytic cracking process provides another option to geosequestration.Read moreRead less
Carbon dioxide-methane exchange in porous media for carbon-neutral energy production. This project aims to incorporate carbon capture and storage into natural gas production from energy reserves. Carbon sequestration could assist in achieving the goals of the Paris Climate Agreement. Injecting carbon dioxide into natural gas reservoirs or methane hydrate sands would be a nearly carbon-neutral means of energy production. However, this exchange of carbon dioxide for methane is poorly understood in ....Carbon dioxide-methane exchange in porous media for carbon-neutral energy production. This project aims to incorporate carbon capture and storage into natural gas production from energy reserves. Carbon sequestration could assist in achieving the goals of the Paris Climate Agreement. Injecting carbon dioxide into natural gas reservoirs or methane hydrate sands would be a nearly carbon-neutral means of energy production. However, this exchange of carbon dioxide for methane is poorly understood in both reservoirs and sands because multiple phases like water and sand affect mixing and recovery. This project will combine spatially-resolved Magnetic Resonance Imaging of high-pressure flooding and exchange experiments with multi-scale modelling. The expected outcome is simultaneous carbon dioxide sequestration with enhanced energy production.Read moreRead less