HIV/AIDS remains a major global threat with ?37 million individuals living with HIV in 2014. Antiretroviral drugs have transformed HIV from a death sentence into a chronic disease. Public health organisations recommend dramatic scale up of drugs for HIV treatment and prevention. However, a major threat is that drug options will be exhausted in the long-term due to drug resistance and toxicity. The major aim of this study is to advance the development of an entirely new drug class for HIV.
Understanding Mitochondrial DNA Segregation And Transmission.
Funder
National Health and Medical Research Council
Funding Amount
$512,449.00
Summary
We inherit our mitochondrial DNA from our mothers. Mutations to mitochondrial DNA can give rise to severely debilitating diseases that can be passed from one generation to the next. The aims of this application are to understand how mutant mitochondrial DNA is selected for; when it affects energy production during development; and to ensure that certain reproductive strategies do not result in the adverse transmission of mitochondrial DNA that will affect subsequent generations.
Discovery Early Career Researcher Award - Grant ID: DE230100056
Funder
Australian Research Council
Funding Amount
$410,154.00
Summary
Accurate Fault Location Methods for Complex Power Networks. This project aims to devise novel algorithms to tackle one of the longstanding and challenging problems in power networks; finding the fault location in power lines. Recent bushfire preventive technologies that have been installed in power networks make the fault location process extremely challenging and time-consuming, leaving communities without power for many hours in extreme heatwave conditions.
The intended outcomes of the projec ....Accurate Fault Location Methods for Complex Power Networks. This project aims to devise novel algorithms to tackle one of the longstanding and challenging problems in power networks; finding the fault location in power lines. Recent bushfire preventive technologies that have been installed in power networks make the fault location process extremely challenging and time-consuming, leaving communities without power for many hours in extreme heatwave conditions.
The intended outcomes of the project are innovative algorithms that are able to pinpoint the fault location more accurately in complex networks, with many fewer measurement devices than conventional methods. This is expected to provide significant benefits for public safety and power supply reliability.Read moreRead less
Mechanisms Underlying APOBEC3G Restriction Of HIV-1
Funder
National Health and Medical Research Council
Funding Amount
$540,075.00
Summary
In the fight against worldwide HIV-AIDS, understanding natural cell defenses to the HIV virus may identify new virus targets and strategies to block HIV in humans. Here, we will use state-of-the-art, high resolution, fluorescent microscopy to understand how the recently identified cell protein, APOBEC3G, blocks the HIV life cycle in human cells. We anticipate that APOBEC3G will stop HIV from invading the nucleus of human cells to defend against HIV, a strategy we can apply to new therapies.
Functional Genomics Of Malaria Liver Infection And Transmission
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
Chemotherapy is the front line defense against malaria but resistance is emerging. The WHO has advised that new drugs should target parasite stages that perpetuate the transmission of malaria to break the cycle of infection. We have identified proteins that are essential for the two transmissive stages of the most deadly parasite to infect their hosts. We will determine the precise function of these proteins and the mechanisms they govern. This may guide the development of new interventions.
Envelope Glycoprotein Determinants Of HIV-1 Subtype C Tropism And Pathogenicity
Funder
National Health and Medical Research Council
Funding Amount
$657,745.00
Summary
HIV-1 subtype C is the most common subtype of HIV-w worldwide, yet we know comparatively little about how it causes disease in humans. This study will elucidate how HIV-1 subtype C evolves in patients to become more pathogenic over time.
Next-Generation Optical Orthogonal frequency-division multiplexing (OFDM) for long-haul telecommunications: building on recent research and commercialisation success. The provision of Broadband Internet services to the home also requires extremely-fast 'backbone' connections between cities to carry the additional traffic demands.
In a previous project funded by the ARC, Monash researchers developed Optical-Orthogonal Frequency Division Multiplexing (OFDM) technology to increase the information- ....Next-Generation Optical Orthogonal frequency-division multiplexing (OFDM) for long-haul telecommunications: building on recent research and commercialisation success. The provision of Broadband Internet services to the home also requires extremely-fast 'backbone' connections between cities to carry the additional traffic demands.
In a previous project funded by the ARC, Monash researchers developed Optical-Orthogonal Frequency Division Multiplexing (OFDM) technology to increase the information-carrying capacity of optical fibers simply by plugging in new circuit boards at exchanges. This is now being commercialised by a new Australian company, to considerable international acclaim. This project aims to provide the next generation of this technology, which will support even faster internet and will ensure the long-term future of Australian telecommunications manufacturing.
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Genomic Approaches To Understand And Control The Emergence Of Vancomycin Resistant Enterococcus Faecium (VREfm) In Australia.
Funder
National Health and Medical Research Council
Funding Amount
$756,163.00
Summary
VRE is a serious hospital superbug that has been increasing in many major hospitals around Australia, while at the same time MRSA (Golden Staph) infections have been decreasing. This project will find out why VRE is increasing by examining what happens to patients at a major Australian hospital from their time of admission to the onset of infection with VRE. At the end of the project we will have the first real understanding of how VRE is transmitted so we can develop effective infection control ....VRE is a serious hospital superbug that has been increasing in many major hospitals around Australia, while at the same time MRSA (Golden Staph) infections have been decreasing. This project will find out why VRE is increasing by examining what happens to patients at a major Australian hospital from their time of admission to the onset of infection with VRE. At the end of the project we will have the first real understanding of how VRE is transmitted so we can develop effective infection control measures.Read moreRead less
Embedded Dispersion Measurement for Fibre Optic Transport Systems. This project addresses an important problem in long-haul optical transport systems and a solution would simplify the deployment, faultfinding and operation of these systems. A positive outcome may lead to an opportunity to license the technology to existing equipment manufacturers. Furthermore, the proposed solution involves optical and electronic technology that is within the capability of Australian industry. There will also ....Embedded Dispersion Measurement for Fibre Optic Transport Systems. This project addresses an important problem in long-haul optical transport systems and a solution would simplify the deployment, faultfinding and operation of these systems. A positive outcome may lead to an opportunity to license the technology to existing equipment manufacturers. Furthermore, the proposed solution involves optical and electronic technology that is within the capability of Australian industry. There will also be the more certain but indirect benefit the research in this project will provide additional stimulus to active and established research community in Australia working on optical devices, subsystems and systems.Read moreRead less