Tapasin And Major Histocompatibility Complex Class I Antigen Presentation
Funder
National Health and Medical Research Council
Funding Amount
$226,650.00
Summary
An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. ....An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. This research proposal aims to examine the role of tapasin in this regard. A thorough understanding of the basic principles of peptide presentation to T cells is crucial to the design of effective vaccines. Furthermore it will also broaden our understanding of immunological responses to cancer, autoimmune diseases and infections.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101178
Funder
Australian Research Council
Funding Amount
$344,324.00
Summary
Water Harvesting and the Cultural Politics of Resource Equity. This project aims to provide a new framework for understanding water equity challenges in urban South Asia. Equitable water access is an everyday struggle in this region. For example, in New Delhi, millions suffer from inadequate supplies, while the wealthy enjoy more than their share. The project plans to investigate how people respond to water stress by adopting techniques such as water harvesting. It also plans to examine the degr ....Water Harvesting and the Cultural Politics of Resource Equity. This project aims to provide a new framework for understanding water equity challenges in urban South Asia. Equitable water access is an everyday struggle in this region. For example, in New Delhi, millions suffer from inadequate supplies, while the wealthy enjoy more than their share. The project plans to investigate how people respond to water stress by adopting techniques such as water harvesting. It also plans to examine the degree to which water harvesting leads to social inclusion or exclusion. Through ethnographic examinations of the water values, resource subjectivities and power dynamics that influence the success of urban water harvesting, the projects intends to gain insights to improve regional water policy and aid effectiveness.Read moreRead less
Social exclusion in adolescence: risks, assets, experiences and policy action. This project aims to investigate social exclusion among young people aged 8 to 17 including the risks of exclusion they face, the assets mobilised to support their inclusion and their life experiences in the context of these risks and assets. The project intends to investigate which risks, assets and experiences are most closely related to outcomes, and how these vary by age and gender. Expected outcomes include a new ....Social exclusion in adolescence: risks, assets, experiences and policy action. This project aims to investigate social exclusion among young people aged 8 to 17 including the risks of exclusion they face, the assets mobilised to support their inclusion and their life experiences in the context of these risks and assets. The project intends to investigate which risks, assets and experiences are most closely related to outcomes, and how these vary by age and gender. Expected outcomes include a new understanding of the relationship between social exclusion and outcomes in adolescence as well as entry points for policy intervention. Addressing social exclusion in adolescence will lead to improved outcomes in health, education and productivity, and a more socially-cohesive society.Read moreRead less
Solar solutions to improve energy affordability for low-income renters. This Project aims to develop solutions for low-income renters to access solar energy. Low-income households spend higher proportions of income on electricity costs. Solar energy is a key way to reduce electricity costs and thus improve energy affordability. Renters are largely excluded from this opportunity. Intended Project outcomes are solutions to access solar energy suitable for widespread application to low-income priva ....Solar solutions to improve energy affordability for low-income renters. This Project aims to develop solutions for low-income renters to access solar energy. Low-income households spend higher proportions of income on electricity costs. Solar energy is a key way to reduce electricity costs and thus improve energy affordability. Renters are largely excluded from this opportunity. Intended Project outcomes are solutions to access solar energy suitable for widespread application to low-income private, public and community rental housing. Adoption of the Project’s outcomes are expected to benefit low-income renters, assist electricity retailers to maintain and extend their customer base, and provide commercial incentives for the many stakeholders providing rental housing and residential solar and battery systems.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Creating better pathways into civic participation for young homeless people through sustainable accommodation and support program models. A sustained independent living environment is a significant contributor to health and well being. This project will offer new insights into how young homeless people use and experience supported accommodation and programs. It will recommend practical models for policy development, practice and service delivery.
Characterising Novel Alternative Splicing Networks That Promote Tumour Cell Plasticity
Funder
National Health and Medical Research Council
Funding Amount
$609,329.00
Summary
During cancer progression, tumour cells can change their properties and become more aggressive and resistant to therapies. We have identified an important regulator of this tumour cell transition, called “Quaking”, which causes widespread changes in gene splicing. We aim to investigate how "Quaking" causes changes in gene splicing and what the effects of these splicing changes are in tumour cells.
Are the kids alright? Understanding the wellbeing of Australian children in their middle years. This project will produce the first comprehensive national stock-take of wellbeing among Australian children in their middle years, with a special focus on children who experience disadvantage. Findings will reflect children's views and experiences, have direct policy relevance and lay the groundwork for comparing and monitoring of child wellbeing.
Improved methods for quantitation of acute phase proteins in biological samples. Using monoclonal antibodies and fluorescence polarisation, we aim to develop improved quantitative analytical methods that are superior to the current clinical assays. The initial targets will be C-reactive protein (CRP) and serum amyloid precursor protein (SAP), but the technology should be readily adaptable to other serum proteins. Better assays for CRP and SAP will greatly facilitate improved clinical management ....Improved methods for quantitation of acute phase proteins in biological samples. Using monoclonal antibodies and fluorescence polarisation, we aim to develop improved quantitative analytical methods that are superior to the current clinical assays. The initial targets will be C-reactive protein (CRP) and serum amyloid precursor protein (SAP), but the technology should be readily adaptable to other serum proteins. Better assays for CRP and SAP will greatly facilitate improved clinical management of those at risk of heart attack, the single biggest contributor to healthcare costs in Australia. We further aim to adapt this technology to enable "point-of-care" assays that would help medical practitioners, especially in rural areas, to make informed diagnoses immediately.Read moreRead less