The Use Of MicroRNA As Novel Therapeutic Targets For Reducing Retinal Inflammation And Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$349,076.00
Summary
Age-Related Macular Degeneration (AMD) is the most common cause of blindness in Australia. We aim to investigate a new class of potential therapeutics, microRNA which are involved in the regulation of many biological processes, including inflammation. A greater understanding of these miRNA will enable discovery of novel therapeutic targets for inflammatory diseases like AMD, and will have further reaching applications in other inflammatory disease such as Alzheimer’s and Parkinson’s.
Implementation Of Dynamic Reference Points And Harvest Strategies To Account For Environmentally-driven Changes In Productivity In Australian Fisheries
Funder
Fisheries Research and Development Corporation
Funding Amount
$552,027.00
Summary
Recently, the risks resulting from not accounting for variability in productivity have become translated into potential risks associated with environmentally driven trends in recruitment, particularly the risk created by ongoing declines in recruitment (and/or growth) driven by climate-change induced trends in water temperature, weather and current patterns.
A number of southeast Australia fish stocks have failed to 'recover' following substantial reductions in catch and effort, and a n ....Recently, the risks resulting from not accounting for variability in productivity have become translated into potential risks associated with environmentally driven trends in recruitment, particularly the risk created by ongoing declines in recruitment (and/or growth) driven by climate-change induced trends in water temperature, weather and current patterns.
A number of southeast Australia fish stocks have failed to 'recover' following substantial reductions in catch and effort, and a number of research projects have concluded that some of these have undergone an environmentally-driven reduction in productivity. A productivity shift has already been demonstrated for Eastern Jackass Morwong, with the stock-recruit relationship and reference points being adjusted to reflect this change. Ecosystem and climate-change modelling have predicted increasing likelihood of similar changes in productivity for a number of Australian fish stocks.
Current harvest strategies assume either equilibrium or some average B0, and associated target (B48) and limit (B20) reference points. Use of equilibrium B0-based reference points and harvest strategies do not correctly reflect the natural dynamics of stocks where productivity changes. This can lead to sub-optimal management, either over-utilising a reduced productivity stock or under-utilising an increased productivity stock. In contrast, reference points based on some proportion of naturally variable unfished biomass (Bunfished or dynamic B0) will fluctuate to follow environmentally-driven productivity changes. Dynamic reference points have been evaluated and adopted for a number of international fisheries.
The need to adapt stock assessment methods and harvest strategies to explicitly and justifiably account for shifts in productivity has been recognised by the AFMA Resource Assessment Group for the Southern and Eastern Scalefish and Shark Fishery (SESSF), not least as a result of clearly evident declines in biomass (Jackass Morwong, Redfish) or recruitment (Silver Warehou) that cannot be attributed to fishing under current productivity assumptions.
Objectives: 1. To review relevant international research and management approaches to account for environmentally-driven productivity change in stock assessments, reference points and harvest strategies for selected Australian fish stocks. 2. To identify and describe circumstances and fish stocks for which dynamic reference points should or should not be used in stock assessments and harvest strategies, and develop appropriate methodology for conducting assessments using dynamic reference points. 3. To identify selected candidate fish stocks showing likely environmentally-driven productivity change, conduct comparative assessments for these stocks using equilibrium and dynamic reference points, and prepare a candidate harvest strategy that includes dynamic reference points for testing in the FRDC Multi-Species Harvest Strategy project. 4. To make recommendations on future implementation of dynamic reference points and harvest strategies for Australian fish stocks. 5. To develop and improve methods for detecting and quantifying changes in productivity (growth and recruitment) in stock assessments, to relate these to environmental mechanisms causing productivity changes, and to evaluate data needs, including environmental indices, required to usefully detect and evaluate productivity change under various circumstances. 6. To consider and evaluate options for effective harvest control rules, incorporating dynamic reference points, that might appropriately respond to changes in fish stock productivity, including environmentally driven trends in productivity. 7. To identify environmental circumstances and fish stock characteristics under which it would be appropriate and advisable to move to using assessments and management approaches incorporating dynamic productivity and reference points, vs. stocks for which dynamic approaches offer no benefit compared to existing equilibrium approaches. 8. To make recommendations on future stock assessment approaches, data requirements, harvest control rules and management approaches incorporating environmental indicators, dynamic productivity and dynamic reference points for Australian fish stocks. Read moreRead less
Development Of Therapeutically Useful Human Artificial Chromosomes For Gene Delivery And Optimal Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$496,986.00
Summary
Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in ....Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in terms of infection, immune response, and germline modification. We have developed the first stage of a new technology for gene delivery that does not require the use of viruses. This technology is based on the generation of human artificial chromosomes, which are smaller versions of the naturally occurring chromosomes that carry all the genes inside our cells. Safety in these artificial chromosomes comes from the use of entirely human materials for their engineering. These artificial chromosomes also have other advantages over the viral approaches, including allowing large genes to be carried, and providing a permanent cure in a single treatment. We have already successfully constructed, published, and patented a number of first-generation human artificial chromosomes. The current project aims to complete the next proof-of-concept milestone towards the further development of this technology. Specifically, we propose to demonstrate the ability of the artificial chromosomes to carry genes and provide sustainable expression of these genes in cells and in animal models. Success in this study will allow the technology to proceed rapidly into commercialisation and clinical trial as a new improved tool for gene delivery and gene therapy.Read moreRead less
Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
New models for the role of chromatin in controlling inducible gene expression. This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these ....New models for the role of chromatin in controlling inducible gene expression. This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these areas are important to the Biotechnology industry. Answering questions about higher order chromatin structure in gene transcription will provide cutting edge, innovative knowledge that will have international significance. Read moreRead less
Discovery Indigenous Researchers Development - Grant ID: DI100100130
Funder
Australian Research Council
Funding Amount
$180,834.00
Summary
Developing predictive tools for rapid assessment of multiple impacts, including climate change, on the marine ecosystem of Torres Strait (Australia). This project will underpin Australia's long-term commitment to maintain environmental biodiversity and sustainability in the face of synergistic effects from multiple threats. We will describe the consequences of threats and stressors on marine processes, harvested resources, and ecosystem functioning by identifying vulnerable species and habitats. ....Developing predictive tools for rapid assessment of multiple impacts, including climate change, on the marine ecosystem of Torres Strait (Australia). This project will underpin Australia's long-term commitment to maintain environmental biodiversity and sustainability in the face of synergistic effects from multiple threats. We will describe the consequences of threats and stressors on marine processes, harvested resources, and ecosystem functioning by identifying vulnerable species and habitats. We will provide management advice on balancing cultural and ecosystem integrity, economic efficiency, and ecosystem resilience under scenarios of climate and environmental change. This information is of immediate use by Australian government agencies. The project will put Australian scientists at the forefront of research focused on the adaptation of marine ecosystems to synergistic effects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237912
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Acoustic tracking key marine species in Tasmania using new technology. We will use new passive listening receivers and uniquely indentifiable acoustic tags to track key marine species (squid, octopus, fish and crustaceans) in Tasmania. This technology allows us to remotely track species with a level of detail previously not available. By using a large number of receivers we will build listening 'curtains'. A series of curtains will then form a multi-species listening grid. This equipment wi ....Acoustic tracking key marine species in Tasmania using new technology. We will use new passive listening receivers and uniquely indentifiable acoustic tags to track key marine species (squid, octopus, fish and crustaceans) in Tasmania. This technology allows us to remotely track species with a level of detail previously not available. By using a large number of receivers we will build listening 'curtains'. A series of curtains will then form a multi-species listening grid. This equipment will allow us to reconstruct movement between habitats, and migration routes to better understand and manage this marine ecosystem. An important feature will involve monitoring organism movements into and out of marine protected areas.Read moreRead less