Self-destructing CRISPR-constructs For Targeted Genome Editing In The Retina.
Funder
National Health and Medical Research Council
Funding Amount
$679,926.00
Summary
Despite the identification of specific mutations causing many inherited retinal dystrophies, all of these conditions are currently untreatable. We have established gene-editing techniques and have developed a novel mouse model, which will serve as a robust platform for testing different techniques of gene editing in the retina. No other group in the world is known to be using this platform for gene editing and our work will expedite the clinical translation of this technology.
Towards a Legal and Institutional Framework for the Conservation and Sustainable Use of High Seas Biodiversity. The legal and institutional challenges required to manage high seas biodiversity have been identified by the United Nations as one of the greatest challenges in oceans management in the 21st century. This Project will research the legal and institutional factors at the national, regional and international levels that militate against conservation of marine biodiversity beyond nation ....Towards a Legal and Institutional Framework for the Conservation and Sustainable Use of High Seas Biodiversity. The legal and institutional challenges required to manage high seas biodiversity have been identified by the United Nations as one of the greatest challenges in oceans management in the 21st century. This Project will research the legal and institutional factors at the national, regional and international levels that militate against conservation of marine biodiversity beyond national jurisdictions and develop practical actions to address the problems identified. The outcome of the Project will be the development of a policy oriented methodology to guide the legal and policy developments on high seas biodiversity conservation at the international and national levels.Read moreRead less
Impacts of climate change on biogenic habitat-forming seaweeds in south east Australia. Seaweed-based systems on rocky reefs in south east Australia support high levels of biodiversity, endemism and economic activity (fisheries). We will provide important insight into how climate change is likely to affect the key habitat-forming seaweeds in this system, and a first assessment of how other marine species will respond to any shift in abundance of the habitat-forming seaweeds. These predictions ar ....Impacts of climate change on biogenic habitat-forming seaweeds in south east Australia. Seaweed-based systems on rocky reefs in south east Australia support high levels of biodiversity, endemism and economic activity (fisheries). We will provide important insight into how climate change is likely to affect the key habitat-forming seaweeds in this system, and a first assessment of how other marine species will respond to any shift in abundance of the habitat-forming seaweeds. These predictions are critical if human adaptation to effects of climate change are to be proactive and not reactive. We will also test a basic assumption of most bio-climate envelope models that are the basis of many current predictions of the effect of climate change on species distributions. The project will provide the basis for training of two PhD students.Read moreRead less
Dark survival in the polar winter. There is strong public interest in both the Arctic and Antarctica and global climate change. By better understanding how these polar ecosystems function in winter and the likely effects of increasing temperatures we will be able to keep the public informed on likely impacts. There are large fishing industries in the Arctic and growing finfish and krill fisheries in the Southern Ocean. This project will contribute to a better understanding of how these stocks wi ....Dark survival in the polar winter. There is strong public interest in both the Arctic and Antarctica and global climate change. By better understanding how these polar ecosystems function in winter and the likely effects of increasing temperatures we will be able to keep the public informed on likely impacts. There are large fishing industries in the Arctic and growing finfish and krill fisheries in the Southern Ocean. This project will contribute to a better understanding of how these stocks will be affected (together with seals, penguins and whales) and how they should be managed to ensure sustainable fisheries and maximum biodiversity.Read moreRead less
Reducing skeletal malformations in cultured marine fish using gene expression, improved nutrition and advanced system operation. Reducing malformations in farmed fish will benefit the Australian economy and society by providing greater quantities of cheaper, higher quality fish. Increased farmed fish production, currently worth ~$300 million p.a., will increase exports and decrease imports (currently ~50% of all Australian consumed fish). To benefit are the important regional farming operations ....Reducing skeletal malformations in cultured marine fish using gene expression, improved nutrition and advanced system operation. Reducing malformations in farmed fish will benefit the Australian economy and society by providing greater quantities of cheaper, higher quality fish. Increased farmed fish production, currently worth ~$300 million p.a., will increase exports and decrease imports (currently ~50% of all Australian consumed fish). To benefit are the important regional farming operations in QLD, NSW, SA, NT, TAS and WA. In particular, the largest industry in Tasmania will profit by having a viable new species to farm (striped trumpeter) reducing risk due to climate change and global oversupply of salmon. Another important benefactor will be the rapidly expanding yellowtail kingfish industry. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237912
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Acoustic tracking key marine species in Tasmania using new technology. We will use new passive listening receivers and uniquely indentifiable acoustic tags to track key marine species (squid, octopus, fish and crustaceans) in Tasmania. This technology allows us to remotely track species with a level of detail previously not available. By using a large number of receivers we will build listening 'curtains'. A series of curtains will then form a multi-species listening grid. This equipment wi ....Acoustic tracking key marine species in Tasmania using new technology. We will use new passive listening receivers and uniquely indentifiable acoustic tags to track key marine species (squid, octopus, fish and crustaceans) in Tasmania. This technology allows us to remotely track species with a level of detail previously not available. By using a large number of receivers we will build listening 'curtains'. A series of curtains will then form a multi-species listening grid. This equipment will allow us to reconstruct movement between habitats, and migration routes to better understand and manage this marine ecosystem. An important feature will involve monitoring organism movements into and out of marine protected areas.Read moreRead less
Genetic and Hormonal Regulation of Plant Growth. Leguminous plants make a substantial contribution to the Australian economy. To ensure future growth, we need to know more about how legume development is regulated. Genetic mutants, typically affecting the growth-promoting gibberellin plant hormones, played a key role in the green revolution, which transformed agriculture world-wide. Recent results show that gibberellin acts in concert with another hormone, auxin. We will generate new auxin-relat ....Genetic and Hormonal Regulation of Plant Growth. Leguminous plants make a substantial contribution to the Australian economy. To ensure future growth, we need to know more about how legume development is regulated. Genetic mutants, typically affecting the growth-promoting gibberellin plant hormones, played a key role in the green revolution, which transformed agriculture world-wide. Recent results show that gibberellin acts in concert with another hormone, auxin. We will generate new auxin-related mutants that will help us to understand how auxin and auxin-mediated interactions affect crop architecture and performance. Further benefit will accrue from training of students in state-of-the-art techniques, and the generation of new germplasm for use by other researchers and plant breeders. Read moreRead less
The role of neurohormones in the regulation of appetite and successful sea water transfer in farmed Atlantic salmon. Cultured Atlantic salmon spend the first part of their life in freshwater and then following a physiological adaption phase called smoltification, the fish (now termed smolts) are transferred to sea cages for growout. A proportion of smolts fail to thrive after transfer, show slow or no growth and usually die some months later. This project will investigate the role that the neuro ....The role of neurohormones in the regulation of appetite and successful sea water transfer in farmed Atlantic salmon. Cultured Atlantic salmon spend the first part of their life in freshwater and then following a physiological adaption phase called smoltification, the fish (now termed smolts) are transferred to sea cages for growout. A proportion of smolts fail to thrive after transfer, show slow or no growth and usually die some months later. This project will investigate the role that the neurohomones that control both appetite and physiological stress in fish have in stimulating the resumption of feeding after sea water transfer.The basic knowledge generated will be used directly in development of strategies for minimising smolt failure in Atlantic salmon aquaculture.Read moreRead less
Genetic and Hormonal Interactions Controlling Shoot Growth. This project will determine how plant growth is regulated at the genetic, biochemical, and physiological levels, and how plant hormones provide key links between the genotype and overall phenotype (phenome). The work uses peas as a model because of the wealth of mutants available and the suitability of the species for physiological and biochemical studies. Our results will allow comparison of development in the caulescent pea plant wi ....Genetic and Hormonal Interactions Controlling Shoot Growth. This project will determine how plant growth is regulated at the genetic, biochemical, and physiological levels, and how plant hormones provide key links between the genotype and overall phenotype (phenome). The work uses peas as a model because of the wealth of mutants available and the suitability of the species for physiological and biochemical studies. Our results will allow comparison of development in the caulescent pea plant with other model species with different growth habits, such as Arabidopsis. The project is significant because it will enable shoot growth to be modified either genetically or chemically to meet particular agronomic objectives.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.