Innovative Health Programs To Reduce Inequality In Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
As part of his Senior NHMRC Fellowship, Prof Simon Stewart, a world-renowned health services researcher, will lead an internationally linked team of researchers from a broad range of health disciplines to undertake a program of research designed to improve the lives of those most vulnerable to heart disease and poor health outcomes. His program of research will focus on Indigenous Australians, patients with complex forms of heart disease and urban African communities in economic transition.
Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Can Skin Infection With Group A Streptococcus Cause Acute Rheumatic Fever?
Funder
National Health and Medical Research Council
Funding Amount
$459,450.00
Summary
It is traditionally taught that the cause of acute rheumatic fever (ARF) is always infection of the throat with the bacterium group A streptococcus (GAS). However, in Aboriginal communities of the Top End of the Northern Territory the incidence of ARF is the highest reported in the world, yet GAS is uncommonly isolated from the throat. There is further information to suggest that GAS skin sores may underlie many cases of ARF. If this were proven, it would completely alter the traditional view of ....It is traditionally taught that the cause of acute rheumatic fever (ARF) is always infection of the throat with the bacterium group A streptococcus (GAS). However, in Aboriginal communities of the Top End of the Northern Territory the incidence of ARF is the highest reported in the world, yet GAS is uncommonly isolated from the throat. There is further information to suggest that GAS skin sores may underlie many cases of ARF. If this were proven, it would completely alter the traditional view of the cause of ARF, and have important implications for prevention of ARF around the world. Presently, these approaches focus on diagnosing and treating sore throat, but no country has proven that such a program can be successful in substantially reducing new cases of ARF. If it was known that skin infection could lead to ARF, then countries (including Australia) could emphasise the importance of skin health programs. A further benefit of this knowledge would be to influence GAS vaccine development, which presently is largely focused on the prevention of sore throat. A different possibility has recently been raised - that the cause of ARF may not always be GAS, but instead that the related bacteria GCS and GGS may have the potential to cause this disease. Proof of this hypothesis would even more dramatically alter our understanding of disease causation, prevention, and vaccine development. We propose to determine the cause of ARF in Aboriginal communities by regularly swabbing families of people with a history of ARF, and using genetic fingerprinting of the bacteria from the skin and throat swabs. When cases of ARF occur, we will be able to determine the site and type of infection that precipitated the attack. We will conduct a related study in more communities, in which we will swab family members of people with ARF and of control families (without ARF) to determine the bacteria most commonly isolated from ARF families.Read moreRead less
CENTRE OF RESEARCH EXCELLENCE TO REDUCE INEQUALITY IN HEART DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$2,607,253.00
Summary
There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health ....There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health care services.Read moreRead less
A National Population-based Study Of Rheumatic Heart Disease In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$877,826.00
Summary
Whilst overall a rare disease, Indigenous peoples have disproportionately high rates of rheumatic heart disease (RHD). This study explores the prevalence and distribution of RHD in pregnancy in Australia and New Zealand. It details current management, diagnostic and referral process and risk factors. Key attributes of culturally safe models of care for RHD in pregnancy are explored, particularly as they relate to Indigenous women. Findings will inform policy, guidelines and education resources.
Discovery Indigenous Researchers Development - Grant ID: DI100100297
Funder
Australian Research Council
Funding Amount
$158,000.00
Summary
Archaeology in the long grass: A study of Aboriginal fringe camp sites in the urban hinterland around Darwin, Australia. This research will contribute to the priority goal of strengthening Australia's social and economic fabric by: 1) advancing the government priority policy commitment to close the gap of Indigenous disadvantage by contributing to social and economic improvements for Indigenous people living in the long grass around Darwin, and other urban centres; 2) contributing to native titl ....Archaeology in the long grass: A study of Aboriginal fringe camp sites in the urban hinterland around Darwin, Australia. This research will contribute to the priority goal of strengthening Australia's social and economic fabric by: 1) advancing the government priority policy commitment to close the gap of Indigenous disadvantage by contributing to social and economic improvements for Indigenous people living in the long grass around Darwin, and other urban centres; 2) contributing to native title debates; 3) developing the research capacity of Indigenous Australians; and 4) increasing public understandings of Aboriginal culture. The Larrakia Nation Aboriginal Corporation will benefit from enhanced research capacity through the quality training of research associates and new data to inform policy decisions and recommendations.Read moreRead less
Improving Sub-national Population Forecasts. The aim of this project is to make significant advances in two related areas of regional, council area and local population forecasting, namely improving accuracy, and providing an indication of forecast uncertainty. Population forecasts often turn out to be far more inaccurate than users realise and fail to come with any information about reliability. Every year forecasts inform a wide variety of planning and policy development activities and influen ....Improving Sub-national Population Forecasts. The aim of this project is to make significant advances in two related areas of regional, council area and local population forecasting, namely improving accuracy, and providing an indication of forecast uncertainty. Population forecasts often turn out to be far more inaccurate than users realise and fail to come with any information about reliability. Every year forecasts inform a wide variety of planning and policy development activities and influence investment decisions worth billions of dollars. In order to increase the value of forecasts to users, this project aims to combine methods from a range of disciplines to devise more accurate ways of forecasting populations, and provide accompanying information on their likely error.Read moreRead less
Families and generational asset transfers: making and challenging wills in contemporary Australia. This project, in collaboration with Public Trust offices across Australia, will provide a national database on which sectors of the population fail to make wills and why. The results will inform innovative service models, law reform initiatives and public education campaigns.
First Nations AI: Country, Climate, Communication. Our team of Indigenous and western scholars aims to develop a systematic account of artificial intelligence and its possibilities in climate change communication in remote First Nations communities in northern Australia. Working under Indigenous governance, we will establish spaces for Indigenous landowners and scientists to come together to probe diverse AI techniques for making sense of climate predictions and risks. We will build the capacity ....First Nations AI: Country, Climate, Communication. Our team of Indigenous and western scholars aims to develop a systematic account of artificial intelligence and its possibilities in climate change communication in remote First Nations communities in northern Australia. Working under Indigenous governance, we will establish spaces for Indigenous landowners and scientists to come together to probe diverse AI techniques for making sense of climate predictions and risks. We will build the capacity of Indigenous people to conceive and design AI, accounting for divergent languages and knowledge systems. This is expected to lead to more effective and trustworthy communications about extreme weather and climate change, improving the preparedness and responses of remote First Nations communities.Read moreRead less
Creative Tropical City: Mapping Darwin's Creative Industries. This research will improve our knowledge and understanding of the creative industries in Darwin. It will provide a strong evidence base for the development of policy options for growing the creative industries in Darwin. And it will interrogate national and international creative industry policy frameworks for their applicability to Darwin.