Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668481
Funder
Australian Research Council
Funding Amount
$140,385.00
Summary
Time-resolved observation of highly transient events by a novel digital high-speed camera. Highly transient, that is, rapidly changing, events occur in nature and in almost every field of science and engineering. Knowledge and understanding of these processes is vital for the design of better and innovative machines, materials and instruments. Valuable insight into these processes can be gained if one can visualise them by means of high-speed photography. This application seeks the acquisition o ....Time-resolved observation of highly transient events by a novel digital high-speed camera. Highly transient, that is, rapidly changing, events occur in nature and in almost every field of science and engineering. Knowledge and understanding of these processes is vital for the design of better and innovative machines, materials and instruments. Valuable insight into these processes can be gained if one can visualise them by means of high-speed photography. This application seeks the acquisition of a novel and unique digital camera system that would allow one to observe rapidly occurring processes with unprecedented clarity. The availability of such a system would significantly strengthen cutting-edge research activities in various disciplines that would ultimately lead to the development of original and innovative products.Read moreRead less
Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Prion-like Behaviour In Immunity: Super-sized Signalling Platforms?
Funder
National Health and Medical Research Council
Funding Amount
$611,995.00
Summary
Prions have been mostly associated with pathologies but recent discoveries show that prion-like behaviour may be beneficial, enhancing our immune response for example. To test this, we want to systematically explore all human proteins involved in the defence against pathogens, find new prion-like trends and probe their role in the innate immune response.
Dust Physics: a Challenge in International Thermonuclear Experimental Reactor. This proposal is highly relevant to development of the electricity-producing fusion power plants. The outcomes will contribute to the achievement of greater control, predictability, and cost efficiency of fusion reactors operation. The project falls within the " An Environmentally Sustainable Australia " research priority and will contribute to development of widely available energy source with essentially unlimited ....Dust Physics: a Challenge in International Thermonuclear Experimental Reactor. This proposal is highly relevant to development of the electricity-producing fusion power plants. The outcomes will contribute to the achievement of greater control, predictability, and cost efficiency of fusion reactors operation. The project falls within the " An Environmentally Sustainable Australia " research priority and will contribute to development of widely available energy source with essentially unlimited supply and manageable environmental impact. Read moreRead less
Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
Nonlinear Phenomena in RF Plasmas for Materials Processing Applications. This coordinated and experimental and theoretical proposal focuses on the investigation of the nonlinear phenomena in radio frequency plasma discharges suitable for material processing applications. The effect of time-varying and steady-state nonlinear plasma responses on the electromagnetic fields and the working parameters of the low-frequency inductively coupled plasmas will be investigated theoretically and experimenta ....Nonlinear Phenomena in RF Plasmas for Materials Processing Applications. This coordinated and experimental and theoretical proposal focuses on the investigation of the nonlinear phenomena in radio frequency plasma discharges suitable for material processing applications. The effect of time-varying and steady-state nonlinear plasma responses on the electromagnetic fields and the working parameters of the low-frequency inductively coupled plasmas will be investigated theoretically and experimentally. The expected outcome of the project will be used for optimizing the performance and stability of the low frequency inductively coupled plasma devices.Read moreRead less
An Australian Program in Precision Flavour Physics. Particle physics is a breakthrough scientific endeavour, addressing fundamental questions about the nature of the laws that govern the Universe we live in. Through engaging in appropriately chosen collaborative experiments at the cutting edge of the field, Australian science can make leading contributions to a deepening understanding that flows from discoveries in this area. Excellent training of young Australian researchers, enhancement of pub ....An Australian Program in Precision Flavour Physics. Particle physics is a breakthrough scientific endeavour, addressing fundamental questions about the nature of the laws that govern the Universe we live in. Through engaging in appropriately chosen collaborative experiments at the cutting edge of the field, Australian science can make leading contributions to a deepening understanding that flows from discoveries in this area. Excellent training of young Australian researchers, enhancement of public interest in science, and fostering of international cooperation and networking are all outcomes which this project will provide.Read moreRead less
Physics of extreme brightness temperatures in radioastronomical sources. Pulsars and some quasars are so very bright that the conventional explanation for radioastronomical emission from other sources either does not apply to them, or presents unsolved problems. We see (in radio waves) these sources through the interstellar medium which acts like a wrinkled pane of glass in distorting the image. New scientific ideas and methodologies are proposed here and will be explored in the project, with th ....Physics of extreme brightness temperatures in radioastronomical sources. Pulsars and some quasars are so very bright that the conventional explanation for radioastronomical emission from other sources either does not apply to them, or presents unsolved problems. We see (in radio waves) these sources through the interstellar medium which acts like a wrinkled pane of glass in distorting the image. New scientific ideas and methodologies are proposed here and will be explored in the project, with the objective to understand these sources and to extract information on their propreties and those of the interstellar medium. Read moreRead less