Electron scattering and transport for plasma-liquid interactions. The project aims to address the emerging technologies associated with the interaction of plasmas with liquids and biological matter, including plasma medicine. The project expects to generate new knowledge on the role of electron-induced processes through the development of complete and accurate sets of microscopic cross-sections for electrons with biomolecules within tissue. This microscopic data will inform new microscopic model ....Electron scattering and transport for plasma-liquid interactions. The project aims to address the emerging technologies associated with the interaction of plasmas with liquids and biological matter, including plasma medicine. The project expects to generate new knowledge on the role of electron-induced processes through the development of complete and accurate sets of microscopic cross-sections for electrons with biomolecules within tissue. This microscopic data will inform new microscopic models for non-equilibrium electron transport in liquids and biological matter, and its coupling to plasmas. The expected outcomes of this project include progress towards the optimisation of safety/efficacy of future generation plasma medicine devices through detailed understanding of plasma-biological tissue interactions.Read moreRead less
Non-equilibrium presolvation electron processes at the gas-liquid interface. The interaction of low-temperature plasma electrons with liquids has served as a reducing agent in various technological applications in water treatment, agriculture, biofuels and medicine. Predictive control of the plasma-liquid interface is essential to unlocking the potential of these applications, and this has been limited by the absence of the relevant non-equilibrium transport theory describing electrons at the pl ....Non-equilibrium presolvation electron processes at the gas-liquid interface. The interaction of low-temperature plasma electrons with liquids has served as a reducing agent in various technological applications in water treatment, agriculture, biofuels and medicine. Predictive control of the plasma-liquid interface is essential to unlocking the potential of these applications, and this has been limited by the absence of the relevant non-equilibrium transport theory describing electrons at the plasma-liquid interface together with fundamental data describing electron interactions with liquids. The project will develop a state of the art presolvation electron transport model informed by world first measurements of electron cross-sections for radicals and liquids and apply it to model plasma electrochemistry processes.Read moreRead less
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Low-energy electron transport in soft-condensed biological matter. To obtain optimal accuracy and selectivity of ionising radiation based technologies requires an understanding and quantification of the underpinning fundamental physical processes. This project will focus on developing accurate theoretical models of low-energy electron transport in biological matter which account for new physical mechanisms.
Slipping out unnoticed: a new bacterial lipoprotein transport system. Worldwide markets for biotechnology-derived products are projected to grow to at least $50 billion per year for the next 10 years. The cornerstone of biotechnology is the production of proteins. The applicant has discovered a new pathway for protein production in bacteria. The primary objective of this project is to use a diverse array of biochemical and biophysical techniques to understand how this new protein production pl ....Slipping out unnoticed: a new bacterial lipoprotein transport system. Worldwide markets for biotechnology-derived products are projected to grow to at least $50 billion per year for the next 10 years. The cornerstone of biotechnology is the production of proteins. The applicant has discovered a new pathway for protein production in bacteria. The primary objective of this project is to use a diverse array of biochemical and biophysical techniques to understand how this new protein production platform works. We will also assess this new pathway for the production of proteins of interest to the biotechnology sector. This project expects to determine how this system can be exploited for use in the growing Australian bioeconomy.Read moreRead less
Novel collision experiments with metastable neon atoms in an atom trap. The aim of this project is to investigate collisions involving atoms in long lived excited states (metastable states). The project will utilise a magneto-optical trap to investigate electron-atom collisions as well as interatomic collisions for ultra-cold atoms. The outcomes of such investigations extend scientific knowledge of these important processes as a well as provide data for testing fundamental scattering theories. T ....Novel collision experiments with metastable neon atoms in an atom trap. The aim of this project is to investigate collisions involving atoms in long lived excited states (metastable states). The project will utilise a magneto-optical trap to investigate electron-atom collisions as well as interatomic collisions for ultra-cold atoms. The outcomes of such investigations extend scientific knowledge of these important processes as a well as provide data for testing fundamental scattering theories. This scientific knowledge may lead to further technological advances such as more efficient light sources or a metastable-atom laser that could be used for the production of nano-scale electric circuits.Read moreRead less
Reconceptualising industry sector development within the contemporary Australian city: The case of the information technology sector. This project will aim to uncover the reasons why Australia's Information Technology industry is ranked low among OECD countries by evaluating the impact of global and urban geography of the sector on the sector's performance. It will show how policies to achieve more advanced IT sector development need to consider Australia's distinctive position in the global eco ....Reconceptualising industry sector development within the contemporary Australian city: The case of the information technology sector. This project will aim to uncover the reasons why Australia's Information Technology industry is ranked low among OECD countries by evaluating the impact of global and urban geography of the sector on the sector's performance. It will show how policies to achieve more advanced IT sector development need to consider Australia's distinctive position in the global economy and particular factors in the Sydney and Melbourne IT clusters that both help, and hinder, development in ways not considered in present policy models.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100151
Funder
Australian Research Council
Funding Amount
$744,000.00
Summary
Multi-kilohertz laser for attosecond and ultrafast science. Griffith University's Australian Attosecond Science Facility was established 12 years ago to facilitate internationally leading research into strong-field laser science. The facility is unique in Australia as it has the capability to precisely manipulate highly-amplified and ultra-short light pulses to investigate the dynamics of matter. The scientific outputs from the facility have delivered important new scientific advances in strong ....Multi-kilohertz laser for attosecond and ultrafast science. Griffith University's Australian Attosecond Science Facility was established 12 years ago to facilitate internationally leading research into strong-field laser science. The facility is unique in Australia as it has the capability to precisely manipulate highly-amplified and ultra-short light pulses to investigate the dynamics of matter. The scientific outputs from the facility have delivered important new scientific advances in strong-field physics enabling the development of new technologies. This grant will be used to procure an upgraded laser system enabling an order of magnitude enhancement of the output light for the next-generation research and maintaining international competitiveness of Australian investigators in this field.Read moreRead less
Exploring Scanning Ultrasound (SUS), A Novel Method To Treat And Prevent Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$765,708.00
Summary
We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.