Directed Molecular Evolution Of G Protein-coupled Receptors For Stable And Functional Expression In Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$383,479.00
Summary
Approximately half of all prescription drugs on the market act on G protein coupled receptors (GPCRs). The mechanisms underlying GPCR function are mainly unknown due to a lack of structural information. No solved structures exist for any of the estimated 800 human GPCRs, making it difficult to design new drugs. By applying advanced protein engineering techniques I aim to produce human GPCRs in bacteria to ultimately acquire structural information, which will enable novel drug development.
Assembly And Function Of Two Interacting Oncogenic Scaffolds
Funder
National Health and Medical Research Council
Funding Amount
$705,585.00
Summary
Aberrant signaling by the protein kinase superfamily is a known driving force for many cancers and inflammatory diseases. Recently, a subset of kinase-like proteins, termed pseudokinases, have emerged as crucial regulators of kinase signalling pathways. This proposal focuses on elucidating the scaffolding function and assembly of two pseudokinases, termed SgK223 and SgK269, which display oncogenic properties and aims to understand how their signalling abilities are subverted in a disease state.
Design And Engineering Of Adnectins For Diagnosis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$803,152.00
Summary
This project aims to engineer a naturally-occurring human protein, called an adnectin, to produce molecules that are able to bind specific targets in the human body, and as such may be used in the diagnosis and therapy of a range of diseases.
Alzheimer’s disease (AD), is the most common form of dementia, accounting for between 50-70% of all cases. There is general agreement that current treatments for AD/dementia are inadequate so new treatment strategies are desperately needed. I am addressing these challenges by developing new technologies to generate next generation treatments for AD.
Crosstalk Between The Repressive Histone Methyltransferases PRC2 And G9A: Structure-function Investigation To Open New Therapeutic Opportunities
Funder
National Health and Medical Research Council
Funding Amount
$595,205.00
Summary
The gene expression programs need to be precisely regulated and the misregulation of these programs can cause a broad range of human diseases. My research will focus on two protein complexes, which heavily contribute to the regulation of gene expression. My study will open a new path for developing new therapeutic strategies.
The New Dimensions of the Quantum Universe. This Fellowship will help build and strengthen significant world-class research capacity at the frontier of fundamental science. More students will be motivated to pursue careers in science, increasing the number of talented, world-class science graduates in Australia. It will forge strong research links both locally and internationally so as to enhance existing networks and create new ones. It will greatly enhance Australia's standing in particle phys ....The New Dimensions of the Quantum Universe. This Fellowship will help build and strengthen significant world-class research capacity at the frontier of fundamental science. More students will be motivated to pursue careers in science, increasing the number of talented, world-class science graduates in Australia. It will forge strong research links both locally and internationally so as to enhance existing networks and create new ones. It will greatly enhance Australia's standing in particle physics, the epitome of Big Science, and garner new respect from one of the world's most influential scientific communities. Having this kind of world-class research in Australia, will also help foster public education and advance the public understanding of fundamental science.
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Branes and unification. This project will explore theories which hypothesis that our universe is a 3-dimensional mem-(brane) residing in higher dimensional space. We will construct completely realistic theories and find ways to test them experimentally. This project is at the forefront of international developments in our understanding of the universe - an area that has grown in importance following the construction of the Large Hadron Collider at the European Giant accelerator laboraroty. The p ....Branes and unification. This project will explore theories which hypothesis that our universe is a 3-dimensional mem-(brane) residing in higher dimensional space. We will construct completely realistic theories and find ways to test them experimentally. This project is at the forefront of international developments in our understanding of the universe - an area that has grown in importance following the construction of the Large Hadron Collider at the European Giant accelerator laboraroty. The project will expose postgraduate students to exciting developments in this fascinating field pf physics.Read moreRead less
Particle physics and cosmology of neutrinos. Neutrinos are a particularly interesting class of elementary particle. The Standard Model of particle physics sees neutrinos as having exactly zero mass. However, recent experimental data have all but demonstrated that massless neutrinos are inconsistent with observations. If neutrinos have mass, then quantum mechanics allows them to oscillate between the different neutrino types as they propagate through space. Nonzero neutrino masses and the associa ....Particle physics and cosmology of neutrinos. Neutrinos are a particularly interesting class of elementary particle. The Standard Model of particle physics sees neutrinos as having exactly zero mass. However, recent experimental data have all but demonstrated that massless neutrinos are inconsistent with observations. If neutrinos have mass, then quantum mechanics allows them to oscillate between the different neutrino types as they propagate through space. Nonzero neutrino masses and the associated oscillations lead to important new physics in the elementary particle domain and in cosmology. This project will explore the implications of neutrino oscillations in diverse areas in particle physics and cosmology.Read moreRead less
The Origin of Mass at the Large Hadron Collider. The Large Hadron Collider is an enormous worldwide effort to understand the building blocks of the Universe. This project will help strengthen world-class research capacity in one of the most exciting frontiers of basic research. It will excite more high-achieving students to pursue careers in science increasing the number of talented graduates in Australia. In addition the big fundamental questions addressed in this research are of great fascin ....The Origin of Mass at the Large Hadron Collider. The Large Hadron Collider is an enormous worldwide effort to understand the building blocks of the Universe. This project will help strengthen world-class research capacity in one of the most exciting frontiers of basic research. It will excite more high-achieving students to pursue careers in science increasing the number of talented graduates in Australia. In addition the big fundamental questions addressed in this research are of great fascination to the general public and will help to further advance the public education of science.Read moreRead less