The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological method ....Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological methods. This work is expected to determine how nanomaterials’ attributes direct pathways for liver cell disposal and describe nanomaterial–liver interactions at the cellular level, information crucial in enabling safer nanomaterials for use in products such as drug formulations, sunscreens and cosmetics.Read moreRead less
Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The ....Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The research facility proposed involves significant training of applied mathematicians at honours, PhD and postdoctoral levels and multidisciplinary collaboration, ensuring that Australia maintains and develops an expertise in nanobiotechnology well into the future.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100040
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this ....ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this Hub include advanced manufacturing capacity for connected sensors, strategic partnerships and commercialisation skills to translate sensors research to create economic benefits such as jobs and locally-made products for domestic and export markets, as well as improving the health of Australians.Read moreRead less
Next generation easy-clean lenses by robust liquid-repellent nanotextures. This project aims to produce better performing self-cleaning lenses, which are less likely to get dirty and are easy to clean. It will develop water and oil repellent coatings with superior optical transparency and mechanical, solvent and UV stability for both hard coated and anti-reflection coated optical lenses. Engineering of stable, ultra-liquid repellent nanomaterials on transparent surfaces will create a foundation ....Next generation easy-clean lenses by robust liquid-repellent nanotextures. This project aims to produce better performing self-cleaning lenses, which are less likely to get dirty and are easy to clean. It will develop water and oil repellent coatings with superior optical transparency and mechanical, solvent and UV stability for both hard coated and anti-reflection coated optical lenses. Engineering of stable, ultra-liquid repellent nanomaterials on transparent surfaces will create a foundation of knowledge for the industrial development of the future generation of easy care coatings, with vast application potential.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100071
Funder
Australian Research Council
Funding Amount
$535,000.00
Summary
Photonic Chip Integration Facility. This project will create a Photonic Chip Integration Facility responding to newly emerging global trends towards low loss waveguides and wider coverage of the optical spectrum.
The tool will grow ultrahigh quality silicon nitride and oxide thin films in a manner that is compatible with electronics and other delicate materials, balancing flexibility for materials exploration with reliability and repeatability required for photonic chip systems research. The pr ....Photonic Chip Integration Facility. This project will create a Photonic Chip Integration Facility responding to newly emerging global trends towards low loss waveguides and wider coverage of the optical spectrum.
The tool will grow ultrahigh quality silicon nitride and oxide thin films in a manner that is compatible with electronics and other delicate materials, balancing flexibility for materials exploration with reliability and repeatability required for photonic chip systems research. The proposed facility will support Australian researchers from diverse disciplines spanning broadband networks, sensing, quantum technology, materials science, and beyond while providing a clear path for translating discoveries out of the lab towards scale up industrial manufacture
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Skin penetration of nanoparticles promoted by particle design, formulation and application method. This project seeks to better define the determinants of nanoparticle skin penetration and subsequent disposition in the body. The data would be used to guide minimal skin penetration of 'undesirable' nanoparticles and the properties required of 'safe' nanoparticles to enable effective human skin delivery in cosmetic and dermatological products.
ARC Centre of Excellence for Carbon Science and Innovation. ARC Centre of Excellence for Carbon Science and Innovation. This Centre aims to develop carbon-based catalysts for clean energy, CO2 capture, and green chemistry to reduce emissions. The Centre expects to use pioneering data-guided atomic-precision synthesis and multiscale analysis to transform fundamental science of carbon materials. Expected outcomes of this Centre will benefit new technologies for energy, environmental, and green che ....ARC Centre of Excellence for Carbon Science and Innovation. ARC Centre of Excellence for Carbon Science and Innovation. This Centre aims to develop carbon-based catalysts for clean energy, CO2 capture, and green chemistry to reduce emissions. The Centre expects to use pioneering data-guided atomic-precision synthesis and multiscale analysis to transform fundamental science of carbon materials. Expected outcomes of this Centre will benefit new technologies for energy, environmental, and green chemical industries by utilising abundant sunlight, seawater, and waste feedstocks. This should provide significant benefits, through industry collaborations, our new world-leading capacity will train a next generation of game changers to empower emerging carbon industries to solve grand socio-economic challenges, ultimately meeting zero-carbon emissions targets.Read moreRead less
Near Infrared (IR) Laser Dyes for Latent Fingermark Detection. This project will enable Australian law enforcement agencies to recover latent fingerprints from difficult surfaces through the use of near infrared dyes. The project will allow the recovery of fingerprints from a scene which would otherwise be lost to an investigation. We will provide new fingerprint development techniques and imaging methods to law enforcement agencies, enhancing their ability to identify a perpetrator and thereb ....Near Infrared (IR) Laser Dyes for Latent Fingermark Detection. This project will enable Australian law enforcement agencies to recover latent fingerprints from difficult surfaces through the use of near infrared dyes. The project will allow the recovery of fingerprints from a scene which would otherwise be lost to an investigation. We will provide new fingerprint development techniques and imaging methods to law enforcement agencies, enhancing their ability to identify a perpetrator and thereby reducing crime rates.Read moreRead less