The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100440
Funder
Australian Research Council
Funding Amount
$419,693.00
Summary
A novel approach in crowd evacuation planning: Behavioural intervention. The ability to rapidly and safely evacuate crowds can mean the difference between death and survival in mass emergencies. While the immediate reaction of the public to an emergency is paramount for their survival, their role in crisis management is often not fully harnessed. This project establishes an innovative and pragmatic approach in urban emergency planning: optimising evacuations through behavioural training. Pioneer ....A novel approach in crowd evacuation planning: Behavioural intervention. The ability to rapidly and safely evacuate crowds can mean the difference between death and survival in mass emergencies. While the immediate reaction of the public to an emergency is paramount for their survival, their role in crisis management is often not fully harnessed. This project establishes an innovative and pragmatic approach in urban emergency planning: optimising evacuations through behavioural training. Pioneering empirical steps will be taken to discover optimum strategies that individual crowd members should adopt, and to establish the extent to which modifying crowd response can be effective. The outcomes will result in educational guides that will increase public awareness and community preparedness for public emergencies.Read moreRead less
Sustainable Australian food production within secure global supply chains. This project aims at exploring future pathways for the Australian food system to remain secure under future disruptive changes, environmentally and socially sustainable, and able to offer healthy food choices. It will reveal the connections among food supply chains, diets and human health, and portray a food system that achieves public health and sustainability goals while positioning Australia securely into the global su ....Sustainable Australian food production within secure global supply chains. This project aims at exploring future pathways for the Australian food system to remain secure under future disruptive changes, environmentally and socially sustainable, and able to offer healthy food choices. It will reveal the connections among food supply chains, diets and human health, and portray a food system that achieves public health and sustainability goals while positioning Australia securely into the global supply chain network. These goals will be achieved by creating the Australian Food Lab, which will provide a collaborative research platform for environmental scientists, economists, public health experts, and food industry representatives for investigating issues pertaining to the future of our food system.Read moreRead less
Multi-Country Study on Health Effects of Bushfire Air Pollution. Catastrophic bushfires are a major natural disaster, causing serious air pollution. However, aligning bushfire air pollution and public health policies becomes a significant challenge, because limited studies are available on relationships between bushfire air pollution and human health, particularly for the prolonged exposure. We will characterize the nature of the relationships between bushfire air pollution and mortality/morbidi ....Multi-Country Study on Health Effects of Bushfire Air Pollution. Catastrophic bushfires are a major natural disaster, causing serious air pollution. However, aligning bushfire air pollution and public health policies becomes a significant challenge, because limited studies are available on relationships between bushfire air pollution and human health, particularly for the prolonged exposure. We will characterize the nature of the relationships between bushfire air pollution and mortality/morbidity by developing a multi-country study; and estimate the burden of diseases attributed to bushfire air pollution. This project will provide essential scientific evidence to policy-makers and stakeholders in the development, prioritization and implementation of health protection strategies and policies.
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Discovery Early Career Researcher Award - Grant ID: DE210100494
Funder
Australian Research Council
Funding Amount
$455,333.00
Summary
A novel electronic nose to locate victims of mass disaster events . The risk of global mass disaster events is increasing due to climate change and acts of terrorism. The most critical action following these events is locating victims. This proposal aims to develop an electronic nose capable of locating living and deceased victims by targeting volatile chemical components emitted from the human body. This project expects to overcome current limitations of current detection methods (e.g. cost, li ....A novel electronic nose to locate victims of mass disaster events . The risk of global mass disaster events is increasing due to climate change and acts of terrorism. The most critical action following these events is locating victims. This proposal aims to develop an electronic nose capable of locating living and deceased victims by targeting volatile chemical components emitted from the human body. This project expects to overcome current limitations of current detection methods (e.g. cost, limited operational time, deployment constraints in hazardous scenarios). The expected project outcomes include the development of innovative techniques that will improve mass disaster recovery on a global scale and provide significant benefit to human welfare. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101652
Funder
Australian Research Council
Funding Amount
$434,404.00
Summary
Assessing climate risk for future food supply. The aim of this project is to assess the impacts of future disruptive climate events and disasters on Australia's food system. This will be achieved by developing a world-first Integrated Assessment Modelling Lab, a collaborative research platform for comprehensive assessment of the effects of extreme climate events (bushfires/drought/floods/cyclones) on Australia's food supply. The project will use this capability to assess impacts on Australia's n ....Assessing climate risk for future food supply. The aim of this project is to assess the impacts of future disruptive climate events and disasters on Australia's food system. This will be achieved by developing a world-first Integrated Assessment Modelling Lab, a collaborative research platform for comprehensive assessment of the effects of extreme climate events (bushfires/drought/floods/cyclones) on Australia's food supply. The project will use this capability to assess impacts on Australia's national and international supply chains, industry sectors and on socio-economic groups. The outcomes will offer opportunities to improve national responses to the changing climate and build resilience by designing adaptation plans to safeguard national and international food supply chains.Read moreRead less
The infectome of NSW dairy calves, a genomic microbial surveillance . Infectious diseases are the main cause of disease and mortality in calves. The knowledge of the diversity of infectious disease-causing agents in NSW dairy cattle is not comprehensive. Thus, the immediate goal of this proposal is to redress this knowledge gap using untargeted microbial genomic sequencing to characterise and identify known and emerging enteric and respiratory pathogens in dairy calves. We will determine the occ ....The infectome of NSW dairy calves, a genomic microbial surveillance . Infectious diseases are the main cause of disease and mortality in calves. The knowledge of the diversity of infectious disease-causing agents in NSW dairy cattle is not comprehensive. Thus, the immediate goal of this proposal is to redress this knowledge gap using untargeted microbial genomic sequencing to characterise and identify known and emerging enteric and respiratory pathogens in dairy calves. We will determine the occurrence and distribution of their microbial species across all NSW dairy regions. This will enable the Australian dairy industry to improve animal health and productivity, and diagnostic capacity, which will allow farmers to make informed management decisions about disease control strategies. Read moreRead less
More than a reserve? Measuring the benefits of private protected areas. This project aims to develop a framework for understanding the full suite of benefits derived from privately protected areas in Australia. It will develop and test a new interdisciplinary approach to measure the ecological, socio-cultural, and economic benefits of protected areas to both human and non-human beneficiaries. Outcomes will include a systematic process to effectively gather data, analyse, and report on the full s ....More than a reserve? Measuring the benefits of private protected areas. This project aims to develop a framework for understanding the full suite of benefits derived from privately protected areas in Australia. It will develop and test a new interdisciplinary approach to measure the ecological, socio-cultural, and economic benefits of protected areas to both human and non-human beneficiaries. Outcomes will include a systematic process to effectively gather data, analyse, and report on the full suite of benefits derived from protected areas. The framework will provide a robust evidence base for the range of benefits provided by private protected areas. This will be vital to manage and grow Australia’s protected area network to reduce biodiversity and environmental declines, and meet international commitments.Read moreRead less
New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput anal ....New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput analytical cultivation, molecular networking, and chemical and biological analyses, expected outcomes include an enhanced ability to explore and exploit valuable chemistry hidden within microbial genomes, leading to the discovery of new classes of natural antiparasitic to safeguard livestock.
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Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less