I am a medical retinal specialist who is involved in a spectrum of basic and clinical research into the cause, risk factors, prevention and treatment of age related macular degeneration, the most common cause of vision loss in Australia.
Blue Mountains Cohort Study: Incidence Of Eye Disease, Hearing Loss And Other Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$813,250.00
Summary
The proposed study aims to determine the cumulative 10-year incidence and progression of the major eye diseases that threaten vision in older Australians, including age-related maculopathy, cataract, glaucoma and diabetic retinopathy. The cumulative 5-year incidence of age-related hearing loss and prevalence of loss of smell will also be determined. The study will assess risk factors and associations with these diseases, using information collected at the baseline, 5-year and 10-year examination ....The proposed study aims to determine the cumulative 10-year incidence and progression of the major eye diseases that threaten vision in older Australians, including age-related maculopathy, cataract, glaucoma and diabetic retinopathy. The cumulative 5-year incidence of age-related hearing loss and prevalence of loss of smell will also be determined. The study will assess risk factors and associations with these diseases, using information collected at the baseline, 5-year and 10-year examinations on medical history, ocular factors, vascular disease, smoking, diet, plus environmental and blood factors. The study aims to assess the impact of these sensory impairments on measures of dependence, quality of life, general health, age-related cognitive impairment, depression and on mortality. The study will be conducted in Katoomba on the cohort of residents from two postcode areas who originally attended the Blue Mountains Eye Study during the period 1992-4. Examinations will commence by May, 2002 and be completed by April, 2004. We hope to examine 2,032 of the original cohort of 3,654 people. This project will build on the data already collected by the Blue Mountains Eye Study, one of the most successful community surveys conducted in Australia. The 10-year follow-up period will provide increased statistical power and precision to assess the role of possible risk factors for eye disease already identified by the earlier baseline and 5-year studies of this population. The hearing component of the study will provide the first longitudinal data on hearing loss from a large older Australian population.Read moreRead less
Inhibition Of Bone Resorption Increases Skeletal Mechanical Strength By Thickening Trabecular Structures
Funder
National Health and Medical Research Council
Funding Amount
$175,648.00
Summary
This project will identify the basis by which a number of therapies for osteoporosis decrease the risk of bone fractures. Currently at least four classes of these compounds in current use for the treatment of osteoporosis. Some of them have been found to have a very marked beneficial effect by halving the risk of fracture. This study will determine if each of these classes of compounds have the ability to increase the mechanical strength of bone to the same level and if each of these compounds h ....This project will identify the basis by which a number of therapies for osteoporosis decrease the risk of bone fractures. Currently at least four classes of these compounds in current use for the treatment of osteoporosis. Some of them have been found to have a very marked beneficial effect by halving the risk of fracture. This study will determine if each of these classes of compounds have the ability to increase the mechanical strength of bone to the same level and if each of these compounds has the same effects on bone structure. Further the effects of stimulating bone formation by subjecting the skeletal to mechanical stress, on the efficacy of each of the therapies will be established. Conversely the effect of aging, which imposes a limitation on bone formation, will be studied.Read moreRead less
Outcome Of High Tibial Osteotomy For Medial Compartment Osteoarthritis Of The Knee: A Long-term Follow-up
Funder
National Health and Medical Research Council
Funding Amount
$65,070.00
Summary
In the young, active person, medial compartment osteoarthritis of the knee is a difficult problem to manage. Surgical options, such as total knee replacement, are often unsuccessful, due to functional restrictions and the need for revision surgery. An alternative is to extend the life of the arthritic knee by moving the primary weight-bearing surface to the other compartment (laterally), in an operation known as a high tibial osteotomy. This research looks at the outcome of this procedure.
Assessment To Service Outcomes - Care Pathways For Older Australians With Dementia, CVD And Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$656,029.00
Summary
The project aims to use existing data source to answer questions similar to �What happens to people after they have been assessed and recommended for aged care? in respect of service delivery for people with one of the three chronic conditions dementia, arthritis or cardiovascular disease. The project is to provide information about issues such as �bed blockers� and determine if the outcomes are different for people who have been assessed for aged care while they are in hospital. It is to chart ....The project aims to use existing data source to answer questions similar to �What happens to people after they have been assessed and recommended for aged care? in respect of service delivery for people with one of the three chronic conditions dementia, arthritis or cardiovascular disease. The project is to provide information about issues such as �bed blockers� and determine if the outcomes are different for people who have been assessed for aged care while they are in hospital. It is to chart changes in service use over time and examine factors that affect the type of care used by older people.Read moreRead less
Relationship Between Nigral Injury, Dopamine Handling And Dyskinesia In Parkinsonism
Funder
National Health and Medical Research Council
Funding Amount
$65,685.00
Summary
Parkinson's Disease is a disabling condition that results from loss of nerve cells (neurones) in the part of the brain known as the substantia nigra (SN). These neurones make dopamine. Symptoms become apparent when 80% of these neurones are gone, suggesting that compensation can occur in the brain. Dopamine can be replaced with the drug L-dopa. Unfortunately this benefit is not sustained and is frequently marred by the production of unpleasant writhing wriggling movements called dyskinesia. Thes ....Parkinson's Disease is a disabling condition that results from loss of nerve cells (neurones) in the part of the brain known as the substantia nigra (SN). These neurones make dopamine. Symptoms become apparent when 80% of these neurones are gone, suggesting that compensation can occur in the brain. Dopamine can be replaced with the drug L-dopa. Unfortunately this benefit is not sustained and is frequently marred by the production of unpleasant writhing wriggling movements called dyskinesia. These movements can also complicate the treatment for schizophrenia and other neurological conditions. The way the brain compensates for loss of SN neurones and why dyskinesia occur is unknown. However we present a hypothesis that the mechanisms for compensation also produce the dyskinesia. We have shown that an injury to the SN results in a compensatory response of vigorous sprouting of the surviving dopamine neurones. This sprouting may also explain why dyskinesias occur. The aim of this study is to establish whether the degree of compensatory response corresponds with the severity of dyskinesia and how this compensatory response can be modified or regulated.Read moreRead less
Osteoporosis is a major and increasing public health problem. Fracture, the ultimate consequence of osteoporosis is associated with significant morbidity, mortality and economic costs. The Dubbo Osteoporosis Epidemiology Study, starting in 1989, with over 2000 women and men, is one of the longest running epidemiological studies in osteoporosis worldwide. It has been at the forefront of epidemiological advances in osteoporosis. It has identified osteoporotic fracture risks including low bone dens ....Osteoporosis is a major and increasing public health problem. Fracture, the ultimate consequence of osteoporosis is associated with significant morbidity, mortality and economic costs. The Dubbo Osteoporosis Epidemiology Study, starting in 1989, with over 2000 women and men, is one of the longest running epidemiological studies in osteoporosis worldwide. It has been at the forefront of epidemiological advances in osteoporosis. It has identified osteoporotic fracture risks including low bone density and bone loss, muscle weakness and postural instability, as well as the extent of the problem in men, and the significant costs, ill-heath and mortality associated with fracture. Despite the clarification of risk factors over the past decade, there are significant gaps in knowledge about osteoporosis, particularly in the accurate prediction of fracture risk and in identification of factors related to fracture-associated mortality and survival post fracture. Although bone density is one of the best predictors of fracture risk, it incompletely discriminates between those who will fracture from those who will not. Although a number of clinical risk factors, and other measures of bone strength, such as quantitative ultrasound and geometry, have been shown to be independent predictors of fracture risk, it is not clear that these measures can be integrated with BMD to improve fracture prediction. The aim of the current study, is to develop and validate models using bone density, other measures of bone strength and clinical parameters that will more accurately predict fracture risk and mortality following fracture in older men and women. The more precise identification of those at high risk of fracture and at risk for poor outcomes following fracture will provide a rational basis for the development of more cost effective interventions for prevention of fracture and its associated morbidity and mortality.Read moreRead less