Australian Laureate Fellowships - Grant ID: FL200100220
Funder
Australian Research Council
Funding Amount
$3,364,492.00
Summary
Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-ass ....Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-associated change in gut bacterial composition, metabolic profiling to identify changes in functionality of the ageing microbiome and a combination of in vitro and in vivo screening approaches to establish molecular mechanisms. The new knowledge will facilitate development of improved models of health care.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL110100199
Funder
Australian Research Council
Funding Amount
$2,529,601.00
Summary
Responding to the challenges of identity change: an advanced social identity approach to issues of leadership, health and well-being. This project develops an integrated framework for understanding how changes to identity that are associated with the changing fabric of the modern world impact on Australians' health and well-being. The project will develop and test strategies for tackling these challenges and minimising their negative consequences.
Australian Laureate Fellowships - Grant ID: FL200100096
Funder
Australian Research Council
Funding Amount
$3,367,940.00
Summary
Mapping the genetic and lifestyle landscape of Healthy Ageing. This project aims to dissect how genes interact with the environment to control healthy ageing using a multidisciplinary approach combining state-of-the-art omics technologies, metabolic and ageing phenotyping and genetic analysis and a highly diverse model system. The project is expected to establish fundamental new understanding of the ageing process by identifying genes that regulate ageing either alone or in response to diet; by ....Mapping the genetic and lifestyle landscape of Healthy Ageing. This project aims to dissect how genes interact with the environment to control healthy ageing using a multidisciplinary approach combining state-of-the-art omics technologies, metabolic and ageing phenotyping and genetic analysis and a highly diverse model system. The project is expected to establish fundamental new understanding of the ageing process by identifying genes that regulate ageing either alone or in response to diet; by defining the mechanism by which such genes control ageing and by identifying biomarkers that predict different ageing outcomes. This knowledge will contribute to future strategies based on genetic testing and biomarkers to optimise healthy ageing in humans. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL180100072
Funder
Australian Research Council
Funding Amount
$3,460,832.00
Summary
Causes and consequence of human trait variation. This project aims to exploit the availability of Big Data from the genomics revolution to understand the relationship between the genome, the environment and complex human traits. New statistical methods and user-friendly software tools will be developed and applied to datasets on millions of individuals to generate new knowledge on human life history variation and healthy ageing. This project will position Australia to benefit from rapid advances ....Causes and consequence of human trait variation. This project aims to exploit the availability of Big Data from the genomics revolution to understand the relationship between the genome, the environment and complex human traits. New statistical methods and user-friendly software tools will be developed and applied to datasets on millions of individuals to generate new knowledge on human life history variation and healthy ageing. This project will position Australia to benefit from rapid advances in genomic technologies, to build and sustain critical capacity in statistical genetics, and better understand the causes and consequence of individual differences in human traits from genetic and environmental factors across the entire human lifespan.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100260
Funder
Australian Research Council
Funding Amount
$2,775,898.00
Summary
Using ancient microbiomes and genomes to reconstruct human history. Using ancient microbiomes and genomes to reconstruct human history. This project aims to generate unique insights into the processes and history that produced the current distribution of modern humans and the bacteria we carry with us (our microbiome). The project will use combined signals of bacterial, genomic and climate data to reconstruct the impacts of migrations, changes in diet, environment, and health in different parts ....Using ancient microbiomes and genomes to reconstruct human history. Using ancient microbiomes and genomes to reconstruct human history. This project aims to generate unique insights into the processes and history that produced the current distribution of modern humans and the bacteria we carry with us (our microbiome). The project will use combined signals of bacterial, genomic and climate data to reconstruct the impacts of migrations, changes in diet, environment, and health in different parts of the world. A key aspect will be the creation of a program to map the genetic history of indigenous Australia, and the impacts of colonisation on indigenous people around the world. Research advances will be transferred to Early Career Researchers through an innovative program of workshops, and the resulting data will be used to create a new format for Australian genetic databases.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL150100096
Funder
Australian Research Council
Funding Amount
$3,030,714.00
Summary
Development of emotional functioning during adolescence. Development of emotional functioning during adolescence: This fellowship project aims to understand factors that increase risk and provide protection from the development of emotional distress during the adolescent years. Adolescence is a critical stage in the development of emotional functioning, and behaviours developed at this time can influence the entire life course. The research plans to follow a large group of teenagers over many ye ....Development of emotional functioning during adolescence. Development of emotional functioning during adolescence: This fellowship project aims to understand factors that increase risk and provide protection from the development of emotional distress during the adolescent years. Adolescence is a critical stage in the development of emotional functioning, and behaviours developed at this time can influence the entire life course. The research plans to follow a large group of teenagers over many years and will focus on risk and protective factors that are open to possible modification. The intended outcomes seek to support the development of prevention and promotion programs and public health initiatives to maximise positive emotional development in young people. It is hoped that these will lead to increased productivity and better quality of life.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL190100011
Funder
Australian Research Council
Funding Amount
$3,232,000.00
Summary
Contemporary life engagement and cognitive resilience in ageing. The aim of this Laureate Fellowship is to make a significant advance in our understanding of cognitive ageing through the adult life course by discovering how contemporary lifestyles and experience impact on cognitive resilience and cognitive function. Population ageing is occurring globally, creating an urgent need for evidence to inform strategies to promote ageing well and productively. Through assessment of adults aged 18-90 (a ....Contemporary life engagement and cognitive resilience in ageing. The aim of this Laureate Fellowship is to make a significant advance in our understanding of cognitive ageing through the adult life course by discovering how contemporary lifestyles and experience impact on cognitive resilience and cognitive function. Population ageing is occurring globally, creating an urgent need for evidence to inform strategies to promote ageing well and productively. Through assessment of adults aged 18-90 (across the life course), this project will evaluation the impact of technology, life space and sensory function on brain structure and function, and cognition. Intended benefits include provision of evidence to inform interventions and policies that optimize cognitive resilience and reduce cognitive decline.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL110100247
Funder
Australian Research Council
Funding Amount
$2,461,000.00
Summary
Understanding the implications of population ageing for the future costs of funding health care, aged care and aged pensions in Australia. Decisions about health insurance, aged care, superannuation and retirement are often very complex, and most people find making the best choices extremely challenging. This project will develop new models and design new policies that can help people make better decisions in these areas, leading to greater well being in retirement.
Australian Laureate Fellowships - Grant ID: FL210100044
Funder
Australian Research Council
Funding Amount
$3,465,000.00
Summary
Governance for Planetary Health Equity. The Laureate Fellowship will use the novel lens of Planetary Health Equity to expose the importance of addressing planetary as well as human systems in achieving global health equity, and investigate the role of governance in realizing that aim. Using international and multi-sectoral comparative analysis, it intends to elucidate how institutions and actors can enable the development of coherent policy and business practices that advance planetary health eq ....Governance for Planetary Health Equity. The Laureate Fellowship will use the novel lens of Planetary Health Equity to expose the importance of addressing planetary as well as human systems in achieving global health equity, and investigate the role of governance in realizing that aim. Using international and multi-sectoral comparative analysis, it intends to elucidate how institutions and actors can enable the development of coherent policy and business practices that advance planetary health equity. Expected outcomes include the design of policies and business practices that promote planetary health equity and a governance framework that enables coherent action. The Laureate has the potential to reduce health inequities and climate change, and relieve pressure on health systems.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992245
Funder
Australian Research Council
Funding Amount
$3,088,350.00
Summary
The Virtual Geological Observatory: a four dimensional view into the Earth through deep-time data-mining. The Fellowship aims to reveal the underlying processes of plate tectonic cycles, paleogeography, sea-level change and the formation of ore deposits and hydrocarbon resources since the explosion of life during the Cambrian period. Using a mantle convection framework, we will discover how the cyclicity in mid-ocean ridge creation and the subduction dynamics associated with the aggregation and ....The Virtual Geological Observatory: a four dimensional view into the Earth through deep-time data-mining. The Fellowship aims to reveal the underlying processes of plate tectonic cycles, paleogeography, sea-level change and the formation of ore deposits and hydrocarbon resources since the explosion of life during the Cambrian period. Using a mantle convection framework, we will discover how the cyclicity in mid-ocean ridge creation and the subduction dynamics associated with the aggregation and dispersal of Gondwana and Pangea has been driving plate tectonic cycles and cyclicity at the Earth's surface. A Virtual Geological Observatory will transform our understanding of this ancient world by fusing geodata-mining and high-performance computer simulation outputs in the plate-tectonic context.Read moreRead less