Assessing gene function in the developing brain using zebrafish as a model system. As the average life expectancy in western countries increases there is an increasing incidence of mental health problems in the general population. Therapeutic approaches to Alzhemier's and Parkinson's disease as well as to brain injury arising from stroke rely on a thorough understanding of the molecular and physiological mechanisms of normal growth of this tissue. These are the very processes that need to be rea ....Assessing gene function in the developing brain using zebrafish as a model system. As the average life expectancy in western countries increases there is an increasing incidence of mental health problems in the general population. Therapeutic approaches to Alzhemier's and Parkinson's disease as well as to brain injury arising from stroke rely on a thorough understanding of the molecular and physiological mechanisms of normal growth of this tissue. These are the very processes that need to be reactivated in these diseases for recovery of function. This project seeks to understand normal development of the brain and in doing so it will expose novel targets for therapy in the aged. Read moreRead less
A prospective study of the mental health of grandparents providing part-time child care for their preschool age grandchildren. This project addresses national research priorities and will identify the characteristics of a high-risk subgroup of Australian grandparents for whom the childcare burden has a deleterious impact on health and well being. Results will enable development of improved approaches to education and awareness in health professionals and the lay community about this subgroup, fa ....A prospective study of the mental health of grandparents providing part-time child care for their preschool age grandchildren. This project addresses national research priorities and will identify the characteristics of a high-risk subgroup of Australian grandparents for whom the childcare burden has a deleterious impact on health and well being. Results will enable development of improved approaches to education and awareness in health professionals and the lay community about this subgroup, facilitating early identification and intervention. The study will provide evidence-based guidance to policy makers about the most appropriate support services for grandparents involved in high levels of childcare, reducing their level of stress and improving the quality of the childcare they provide.
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A prospective study of the transition to grandparenthood: psychosocial adjustment, well-being and productive ageing. Given the increasingly common childcare role that grandparents are required to play in Australian society, and the increasing demands of grandparenting, potential benefits arising from this study adhere to the requirements of the National Research Priority Area "Promoting and Maintaining Good Health." They include: identifying the characteristics of the group of grandparents for w ....A prospective study of the transition to grandparenthood: psychosocial adjustment, well-being and productive ageing. Given the increasingly common childcare role that grandparents are required to play in Australian society, and the increasing demands of grandparenting, potential benefits arising from this study adhere to the requirements of the National Research Priority Area "Promoting and Maintaining Good Health." They include: identifying the characteristics of the group of grandparents for whom the change of role and lifestyle produces negative effects; providing increased awareness in health professionals and the lay community about this subgroup, enabling appropriate early identification and intervention; supplying evidence-based data to inform strategies to reduce stress in the grandparents and improve the quality of childcare they provide.Read moreRead less
Investigating older Australians' beliefs about and understanding of mental health and their practice of relevant protective behaviours. Healthy ageing and mental health are acknowledged national priorities. This project will generate new knowledge relating to older Australians' mental health literacy and the motivators and barriers influencing their engagement in protective behaviours. The resulting communications strategy will provide tangible outcomes for the industry partners to utilise. The ....Investigating older Australians' beliefs about and understanding of mental health and their practice of relevant protective behaviours. Healthy ageing and mental health are acknowledged national priorities. This project will generate new knowledge relating to older Australians' mental health literacy and the motivators and barriers influencing their engagement in protective behaviours. The resulting communications strategy will provide tangible outcomes for the industry partners to utilise. The project will thus produce knowledge advancement and tools for practitioners, both of which will enhance public welfare and reduce long-term healthcare costs. While this project focuses on older Australians, those of all ages will benefit from a communications campaign that provides individuals with knowledge to protect and strengthen their mental health.Read moreRead less
Preventing Suicide: A psychological autopsy study of the last contact with a health professional before suicide. In Australia, 48% of all suicides in 2000 were by 35-64 year olds; an additional 13% were by 65 years and over. This study will examine the last clinical contact older suicide victims had with health professionals in order to determine whether this contact offers an opportunity for intervention. For the first time in Australia, GP's, health professionals, and the deceased's next-of-ki ....Preventing Suicide: A psychological autopsy study of the last contact with a health professional before suicide. In Australia, 48% of all suicides in 2000 were by 35-64 year olds; an additional 13% were by 65 years and over. This study will examine the last clinical contact older suicide victims had with health professionals in order to determine whether this contact offers an opportunity for intervention. For the first time in Australia, GP's, health professionals, and the deceased's next-of-kin will be interviewed to determine the context surrounding the deceased's death, and the abilities of health professionals to identify warning signs and to intervene prior to suicide. Given our ageing population, the outcomes will be significant in educating all health professionals to identify suicidal signs, and to prevent premature death in the elderly.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882275
Funder
Australian Research Council
Funding Amount
$110,000.00
Summary
Facility for analysing behaviour, learning and motor skills in animal models. Mental disorders are one of the largest costs to the community today and account for more than 50% of the time lost from work. Moreover, these disorders are disabling conditions that relate to fundamental, basic questions of identity and individuality. This collaborative behavioural facility at The University of Queensland will underpin excellent research into how neurological changes affect behaviour and thinking, pro ....Facility for analysing behaviour, learning and motor skills in animal models. Mental disorders are one of the largest costs to the community today and account for more than 50% of the time lost from work. Moreover, these disorders are disabling conditions that relate to fundamental, basic questions of identity and individuality. This collaborative behavioural facility at The University of Queensland will underpin excellent research into how neurological changes affect behaviour and thinking, provide infrastructure to test current models on brain functions, and support the development of new compounds to treat these disorders, thus resulting in significant national and community benefits in improved health outcomes and increased work productivity.Read moreRead less
The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perce ....The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perceive and manage important aspects of human diversity.Read moreRead less
Novel cellular functions of the microtubule-associated protein tau: Physiological and pathological implications. The social and economic burden of Alzheimer's disease (AD) is enormous, and by 2040 more than 500,000 Australians will suffer from this disease. A key histopathological hallmark of this and many other related diseases are insoluble deposits of the protein tau. Research into novel functions of tau in signalling and transport (both of which are heavily compromised in diseased brains) wi ....Novel cellular functions of the microtubule-associated protein tau: Physiological and pathological implications. The social and economic burden of Alzheimer's disease (AD) is enormous, and by 2040 more than 500,000 Australians will suffer from this disease. A key histopathological hallmark of this and many other related diseases are insoluble deposits of the protein tau. Research into novel functions of tau in signalling and transport (both of which are heavily compromised in diseased brains) will be followed directly by assay development for tau-directed drug screening. The national benefit of this research is manifold by (a) patenting new data, (b) developing treatment strategies for an un-curable disease, and (c) establishing links to the growing Australian biotech industry (in addition to existing links to international pharmaceutical companies).Read moreRead less
Pathogenesis of Alzheimer's disease: Dissecting synaptosomal dysfunction in transgenic animal models. There is no cure for Alzheimer's disease (AD). This project will dissect pathogenic mechanisms, identify new drug targets, and develop treatment strategies, all of which will be patented and eventually lead to a decrease in health costs in Australia. This research clearly falls under the national research priority of promoting and maintaining good health. Our findings are expected to benefit pat ....Pathogenesis of Alzheimer's disease: Dissecting synaptosomal dysfunction in transgenic animal models. There is no cure for Alzheimer's disease (AD). This project will dissect pathogenic mechanisms, identify new drug targets, and develop treatment strategies, all of which will be patented and eventually lead to a decrease in health costs in Australia. This research clearly falls under the national research priority of promoting and maintaining good health. Our findings are expected to benefit patients in addition to those suffering from AD, as pathocascades and pathogenic mechanisms are shared between a range of neurodegenerative disorders. Read moreRead less
Characterisation of a novel neural-specific ATPase in cholesterol transport. Ageing is determined by both genetic and metabolic factors. To a large part, the detailed mechanisms of ageing remain to be unexplored. Genetically, the timing of cell ageing entails the loss of telomeres (tips of chromosomes). However, the buildup of metabolic wastes resets the timing prematurely. Metabolic products accumulate from excess production or a shortfall of removal activity, which occurs in the various parts ....Characterisation of a novel neural-specific ATPase in cholesterol transport. Ageing is determined by both genetic and metabolic factors. To a large part, the detailed mechanisms of ageing remain to be unexplored. Genetically, the timing of cell ageing entails the loss of telomeres (tips of chromosomes). However, the buildup of metabolic wastes resets the timing prematurely. Metabolic products accumulate from excess production or a shortfall of removal activity, which occurs in the various parts of ageing cells in tissues such as brain. Traffic jams of cholesterol transport in the secretory pathway induce early ageing of the nerve cells. We investigate a novel mechanism controlling cholesterol transport in nerve cell ageing.Read moreRead less