A technology platform for multiple body site image-omics. The project aim is to derive a technology platform comprising new image processing and machine learning algorithms to integrate imaging and biological data across multiple body sites. The relationships between image features and biological data across multiple sites has not been discovered before. We propose the use of biological information from one sampled site to investigate other unsampled sites based on imaging-omics correspondences. ....A technology platform for multiple body site image-omics. The project aim is to derive a technology platform comprising new image processing and machine learning algorithms to integrate imaging and biological data across multiple body sites. The relationships between image features and biological data across multiple sites has not been discovered before. We propose the use of biological information from one sampled site to investigate other unsampled sites based on imaging-omics correspondences. We will use a data-driven, searchable graph model approach for knowledge discovery within the population data. The project will provide new insights into systems biology and bioinformatics that will then inform and promote benefits in life sciences, with potential future benefits in healthcare.Read moreRead less
Active and interactive analysis of prescription data for harm minimisation. Active and interactive analysis of prescription data for harm minimisation. This project aims to enhance prescription monitoring to reduce and prevent dangers to the public from inappropriate drug use. The project will develop a framework integrating active machine learning, interactive data mining, and data visualization into analysis of prescription data. The expected outcomes include online interactive analysis of lar ....Active and interactive analysis of prescription data for harm minimisation. Active and interactive analysis of prescription data for harm minimisation. This project aims to enhance prescription monitoring to reduce and prevent dangers to the public from inappropriate drug use. The project will develop a framework integrating active machine learning, interactive data mining, and data visualization into analysis of prescription data. The expected outcomes include online interactive analysis of large scale prescription data and a system that can interact with health professionals to provide high quality real time prescription monitoring, thereby improving patient outcomes and the efficiency of the healthcare system.Read moreRead less
The development of automated advanced data analysis techniques for the detection of aberrant patterns of prescribing controlled drugs. The state of the art in ICT for healthcare monitoring is rapidly advancing, however, the value of data depends on effective tools and techniques. This project will develop novel techniques for the detection of emerging patterns in the prescribing of controlled drugs, supporting Queensland Health’s role in patient harm minimisation.
Reconstructing proteins to explain and engineer biological diversity. The aim of this project is to develop computational methods to construct entirely new proteins. Computational reconstruction of enzymes that have been extinct for over 400 million years has revealed remarkable opportunities for biotechnological innovation. The intended outcomes are to develop bioinformatics methods to broaden the scope of ancestral protein reconstruction to include protein super-families, to establish what spe ....Reconstructing proteins to explain and engineer biological diversity. The aim of this project is to develop computational methods to construct entirely new proteins. Computational reconstruction of enzymes that have been extinct for over 400 million years has revealed remarkable opportunities for biotechnological innovation. The intended outcomes are to develop bioinformatics methods to broaden the scope of ancestral protein reconstruction to include protein super-families, to establish what specific changes led to the evolutionary success of a protein, and to re-run evolution to generate proteins that perform in conditions suitable for industrial and agricultural applications, in particular the production of hydroxylated fatty acids for bioplastics. By examining proteins from many life forms, the project plans to develop a novel bioinformatics strategy to understand their evolution and engineer new proteins for use in production of chemical commodities.Read moreRead less
An integrated virtual functional human body (VFHB). This research is aimed at extracting and harnessing new knowledge from the immense volume of biomedical imaging data that is currently generated in healthcare through innovative information technologies. These technologies will allow a ‘virtual functional human body’ in a realistic, comprehensible visual format to be built, which will be accessible to researchers and lay individuals. It is expected that it will lead to a paradigm-change in the ....An integrated virtual functional human body (VFHB). This research is aimed at extracting and harnessing new knowledge from the immense volume of biomedical imaging data that is currently generated in healthcare through innovative information technologies. These technologies will allow a ‘virtual functional human body’ in a realistic, comprehensible visual format to be built, which will be accessible to researchers and lay individuals. It is expected that it will lead to a paradigm-change in the delivery of information systems, scientific discovery and impact on a lay individual's perception of their health status such that it will empower them to actively participate in their health and general well-being.Read moreRead less
Large-scale computational modelling of epidemics in Australia. The project aims to develop novel computational epidemiological models to contribute to guidelines for optimal prophylaxis, vaccination and case management. Emerging threats posed by infectious diseases and bioterrorism could have dramatic effects on the Australian population, productivity and economy. The project aims to improve the accuracy and scope of modern computational epidemiological models by integrating large-scale Census d ....Large-scale computational modelling of epidemics in Australia. The project aims to develop novel computational epidemiological models to contribute to guidelines for optimal prophylaxis, vaccination and case management. Emerging threats posed by infectious diseases and bioterrorism could have dramatic effects on the Australian population, productivity and economy. The project aims to improve the accuracy and scope of modern computational epidemiological models by integrating large-scale Census datasets and explicitly simulating the entire population down to the level of single individuals, coupled with complex network-based and information flow analysis. The intended outcomes include a more precise and efficient forecasting of critical epidemic dynamics, and increased effectiveness of prevention, mitigation and management of socio-economic, socio-ecological and national security crises.Read moreRead less
Developing a Hemodynamic Model for Improving Clinical Treatment of Vascular Diseases. Stroke caused by vascular diseases is the second greatest single killer, which is taking away thousands of lives and costing billions every year in Australia. Improving the existing clinical treatments of these diseases is thus of utmost urgency. This project is targeted to developing a reliable Hemodynamic model through comprehensive experimental validation approach. It will not only foster a more in-depth res ....Developing a Hemodynamic Model for Improving Clinical Treatment of Vascular Diseases. Stroke caused by vascular diseases is the second greatest single killer, which is taking away thousands of lives and costing billions every year in Australia. Improving the existing clinical treatments of these diseases is thus of utmost urgency. This project is targeted to developing a reliable Hemodynamic model through comprehensive experimental validation approach. It will not only foster a more in-depth research of vascular diseases but also provide a virtual forecasting tool for physicians or surgeons to develop guidance on diagnosis and therapeutic planning of clinical treatment, which brings great socio-economic benefit to the health of the Australian community.Read moreRead less
Superhuman place recognition with a unified model of human visual processing and rodent spatial memory. Current robotic and personal navigation systems leave much to be desired; GPS only works in open outdoor areas, lasers are expensive and cameras are highly sensitive to changing environmental conditions. In contrast, nature has evolved superb navigation systems. This project aims to solve the challenging problem of place recognition, a key component of navigation, by modelling the visual recog ....Superhuman place recognition with a unified model of human visual processing and rodent spatial memory. Current robotic and personal navigation systems leave much to be desired; GPS only works in open outdoor areas, lasers are expensive and cameras are highly sensitive to changing environmental conditions. In contrast, nature has evolved superb navigation systems. This project aims to solve the challenging problem of place recognition, a key component of navigation, by modelling the visual recognition skills of humans and the rodent spatial memory system. This project looks to combine the best understood and most capable components of place recognition in nature to create a whole more capable than its parts, produce advances in robotic and personal navigation technology and lead to breakthroughs in understandings of the brain.Read moreRead less
Topological Approaches for Three Dimensional Graph Drawing. Human analysis of huge quantities of relational data in biotechnology, web engineering, social networks, and computer networks requires visualization. In recent years, three-dimensional visualisation has promised to give new insights into such abstract data. However the past ten years of visualization research has had very little impact on the industry; visualization software providers have not adopted visualization methods developed b ....Topological Approaches for Three Dimensional Graph Drawing. Human analysis of huge quantities of relational data in biotechnology, web engineering, social networks, and computer networks requires visualization. In recent years, three-dimensional visualisation has promised to give new insights into such abstract data. However the past ten years of visualization research has had very little impact on the industry; visualization software providers have not adopted visualization methods developed by academics. We hypothesise that current 3D relational visualization methods fail because they do not pay attention to the human perception of topology. In this project we will leverage mathematical topology to construct new methods for the 3D visualization of relational data.
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New Methods for Interactive Visualization of Large Microarray Data Sets. This project will investigate methods for visualising graphs produced by AI-based analysis of real-world biological data. These new visualisation methods will assist biologists to develop new DNA Microarray experiments, the source of raw data for visualisation. Data from new enhanced experiments, plus background knowledge from integrated public databases will produce richer data for visualisation, thus creating a positive f ....New Methods for Interactive Visualization of Large Microarray Data Sets. This project will investigate methods for visualising graphs produced by AI-based analysis of real-world biological data. These new visualisation methods will assist biologists to develop new DNA Microarray experiments, the source of raw data for visualisation. Data from new enhanced experiments, plus background knowledge from integrated public databases will produce richer data for visualisation, thus creating a positive feedback loop in the course of research into both topics.Read moreRead less