Enabling Methodologies for the Synthesis of Biologically Active Compounds. This project seeks to establish flexible methods of chemical synthesis for creating new molecular scaffolds capable of achieving selective enzyme inhibition. The approach aims to exploit the vast and biologically-programmed structural diversity associated with natural products. Unique, small molecule organic compounds will be obtained that reveal details of the operation of key enzymes in bacterial and mammalian systems. ....Enabling Methodologies for the Synthesis of Biologically Active Compounds. This project seeks to establish flexible methods of chemical synthesis for creating new molecular scaffolds capable of achieving selective enzyme inhibition. The approach aims to exploit the vast and biologically-programmed structural diversity associated with natural products. Unique, small molecule organic compounds will be obtained that reveal details of the operation of key enzymes in bacterial and mammalian systems. Such new knowledge would allow for the design of highly selective therapeutic agents relevant to the treatment of a range of diseases including bacterial infections, diabetes and cancer. The high-end scientific training and privileged forms of matter arising from this work would provide major benefit to the biotech sector.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100803
Funder
Australian Research Council
Funding Amount
$365,094.00
Summary
Impact of screen time on preschoolers’ social skills and cognitive function. This project aims to determine how the quantity and nature of screen time interacts with parental co-participation to affect pre-schoolers’ social skills and cognitive functioning. Seventy per cent of pre-schoolers exceed current screen time guidelines and this causes considerable concern among Australian parents. This project will assist in evaluating how much, and which types, of screen time have benefits for social ....Impact of screen time on preschoolers’ social skills and cognitive function. This project aims to determine how the quantity and nature of screen time interacts with parental co-participation to affect pre-schoolers’ social skills and cognitive functioning. Seventy per cent of pre-schoolers exceed current screen time guidelines and this causes considerable concern among Australian parents. This project will assist in evaluating how much, and which types, of screen time have benefits for social skills and cognitive functioning. It will also provide insights into the ways parents may best support these outcomes. Findings are expected to provide evidence for policy development and inform programs to support healthy behaviours to give young children the best start in life.Read moreRead less
Synthetic genes as reference standards for biology and biomanufacture. Reference standards are needed to improve the measurement of biology and the reliability of biomanufacturing processes. This project aims to engineer synthetic genes capable of acting as reference standards for DNA, RNA and protein. The synthetic genes can be transcribed into mRNA standards, and translated into protein standards, and be further integrated into living cells to measure internal cellular processes.
The outcomes ....Synthetic genes as reference standards for biology and biomanufacture. Reference standards are needed to improve the measurement of biology and the reliability of biomanufacturing processes. This project aims to engineer synthetic genes capable of acting as reference standards for DNA, RNA and protein. The synthetic genes can be transcribed into mRNA standards, and translated into protein standards, and be further integrated into living cells to measure internal cellular processes.
The outcomes include a unified understanding of gene expression and more accurate next-generation sequencing and mass-spectrophotometry technologies. The synthetic genes also allow standardisation and optimisation of biomanufacturing processes that will produce mRNA and biologics products at a higher purity and lower cost.Read moreRead less
Improving predictions of species distribution dynamics. This project aims to mainstream methods for improved prediction of species distributions under the impacts of environmental change. This is important because these predictions are commonly used to guide environmental decisions, but the standard modelling methods used to produce them have critical limitations. This project intends to (i) make key statistical developments to methods for modelling dynamics of species distributions and (ii) tra ....Improving predictions of species distribution dynamics. This project aims to mainstream methods for improved prediction of species distributions under the impacts of environmental change. This is important because these predictions are commonly used to guide environmental decisions, but the standard modelling methods used to produce them have critical limitations. This project intends to (i) make key statistical developments to methods for modelling dynamics of species distributions and (ii) translate the methods into practice, through guidelines, tools and training, engagement with users and case studies addressing species of current concern. This should provide significant benefits because it will enable better decisions and more effective and cost-efficient management actions.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100578
Funder
Australian Research Council
Funding Amount
$355,208.00
Summary
Next generation soil carbon satellite-based measurement for carbon markets. Soil carbon sequestration is a federal government priority to offset greenhouse gas emissions. Efforts to advance this opportunity are hindered by the high technical costs of soil carbon quantification. This project will develop an innovative and potentially commercialisable technology that integrates ground data, unmanned aerial vehicles (UAVs), satellites, Eddy covariance CO2 flux towers, soil carbon (C) models, and ar ....Next generation soil carbon satellite-based measurement for carbon markets. Soil carbon sequestration is a federal government priority to offset greenhouse gas emissions. Efforts to advance this opportunity are hindered by the high technical costs of soil carbon quantification. This project will develop an innovative and potentially commercialisable technology that integrates ground data, unmanned aerial vehicles (UAVs), satellites, Eddy covariance CO2 flux towers, soil carbon (C) models, and artificial intelligence (AI) to improve the accuracy of satellite-based soil C modelling. The project will provide an accurate and cost-effective solution to quantification of soil C changes to unlock a large potential of carbon offsets in rangelands in Australia and worldwide.Read moreRead less