Development and Evaluation of Well-Defined Polymer-RNA Conjugates as Improved Therapeutics. Gene-based drugs offer an enormous potential to treat a wide range of diseases including, but not limited to, AIDS, hepatitis, and cancer. However, effective delivery of these drugs in body is needed to convert their therapeutic potential to clinically applicable treatments. Our multidisciplinary team will aim to develop novel, polymer-gene hybrid materials for efficient delivery of gene based therapeuti ....Development and Evaluation of Well-Defined Polymer-RNA Conjugates as Improved Therapeutics. Gene-based drugs offer an enormous potential to treat a wide range of diseases including, but not limited to, AIDS, hepatitis, and cancer. However, effective delivery of these drugs in body is needed to convert their therapeutic potential to clinically applicable treatments. Our multidisciplinary team will aim to develop novel, polymer-gene hybrid materials for efficient delivery of gene based therapeutics. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of new materials and strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project. Read moreRead less
Biodegradable Porous HEMA-Based Polymers: Innovative Strategies for the Design and Tuneable Single-Step Production of a Novel Class of Scaffolds for Tissue Engineering. This project will lead to the development of new biocompatible, biodegradable, porous materials ideally suited to many applications in tissue engineering. These new biomaterials will be relatively inexpensive to manufacture, via simple processes using non-toxic reagents. The key properties of the biomaterials will be controllable ....Biodegradable Porous HEMA-Based Polymers: Innovative Strategies for the Design and Tuneable Single-Step Production of a Novel Class of Scaffolds for Tissue Engineering. This project will lead to the development of new biocompatible, biodegradable, porous materials ideally suited to many applications in tissue engineering. These new biomaterials will be relatively inexpensive to manufacture, via simple processes using non-toxic reagents. The key properties of the biomaterials will be controllable by appropriate choice of starting materials. The availability of these new biomaterials will facilitate future developments in tissue engineering, which will ultimately lead to improved medical outcomes in areas as diverse as joint and bone repair and organ regeneration. Local manufacture of these biomaterials would also contribute to the development of the Australian biotechnology industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989125
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Enhanced Capacity in Ultra-Trace Level Detection and Speciation of Compounds of Environmental, Biological and Materials Science Interest. The proposed integrated facility will strongly support collaborative research in areas of high national priority. These are environmental sustainability, development of new materials and designing molecules of therapeutic value on the basis of better understanding the relevant biological processes. This support will lead to maximizing the outcomes of numerous ....Enhanced Capacity in Ultra-Trace Level Detection and Speciation of Compounds of Environmental, Biological and Materials Science Interest. The proposed integrated facility will strongly support collaborative research in areas of high national priority. These are environmental sustainability, development of new materials and designing molecules of therapeutic value on the basis of better understanding the relevant biological processes. This support will lead to maximizing the outcomes of numerous projects already funded by the Australian Research Council which require accurate and highly sensitive analysis. This will improve the cost effectiveness of research funding and will further strengthen the outstanding reputation of Australia science worldwide.Read moreRead less
Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anti ....Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anticancer drugs. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project.Read moreRead less
Controlled synthesis of well-aligned single crystalline one-dimensional semiconducting nanomaterials for energy application. This proposal is at the forefront of a number of important fields, and therefore the outcomes are expected to be of great interest to a broad spectrum of industry sectors, including advanced materials, nanotechnology, and sustainable energy. The novel synthetic methods and the targeting material system could lead to advanced materials for energy application. The outcomes o ....Controlled synthesis of well-aligned single crystalline one-dimensional semiconducting nanomaterials for energy application. This proposal is at the forefront of a number of important fields, and therefore the outcomes are expected to be of great interest to a broad spectrum of industry sectors, including advanced materials, nanotechnology, and sustainable energy. The novel synthetic methods and the targeting material system could lead to advanced materials for energy application. The outcomes of this project will place Australian researchers among the pioneering groups in this area and will benefit several major technology-related fields including materials manufacture technology and sustainable energy.Read moreRead less
Preparations, Properties, and Applications of New Hydrogels. This project aims to develop a new polymeric matrix system for improved biological separations such as fibrinogen, DNA and RNA. These new hydrogels and membranes will not only be capable of separating biomacromolecules, not possible within the existing systems, but will also develop a new size exclusion type separation system for electrophoresis. The success of the project will have a significant impact in the biotechnology industry. P ....Preparations, Properties, and Applications of New Hydrogels. This project aims to develop a new polymeric matrix system for improved biological separations such as fibrinogen, DNA and RNA. These new hydrogels and membranes will not only be capable of separating biomacromolecules, not possible within the existing systems, but will also develop a new size exclusion type separation system for electrophoresis. The success of the project will have a significant impact in the biotechnology industry. Particularly, it will provide efficient methodologies to fractionate a number of important blood products and strengthen Australian's leading role in this field.Read moreRead less
Rubbery nanoparticles for improved plastics, additives and adhesives through novel low-temperature polymerization. This project will create the enabling science for producing better pressure-sensitive adhesives, leather treatment, bitumen additives and engineering plastics, by the first-ever synthesis of acrylic latex at low temperatures. This will allow certain reaction processes to predominate that will result in molecular architectures that are very different from those currently made. The re ....Rubbery nanoparticles for improved plastics, additives and adhesives through novel low-temperature polymerization. This project will create the enabling science for producing better pressure-sensitive adhesives, leather treatment, bitumen additives and engineering plastics, by the first-ever synthesis of acrylic latex at low temperatures. This will allow certain reaction processes to predominate that will result in molecular architectures that are very different from those currently made. The result will be enhanced material properties, such as better-wearing leather coatings, greater scratch and shock resistance in vehicle and domestic plastics (with reduced environmental insult in manufacture and usage), improved endurance for bitumen road surfaces, and layered packaging that needs less adhesive per unit of strength.Read moreRead less
Novel nanostructured InVO4 and related vanadates photocatalysts for water splitting under visible light irradiation. This proposal is at the forefront of a number of important fields, and therefore the outcomes are expected to be of great interest to a broad spectrum of industry sectors, including sustainable energy supply, solar energy applications, and environmental purification. This novel material system could lead to highly efficient photocatalysts for application in solar energy to split w ....Novel nanostructured InVO4 and related vanadates photocatalysts for water splitting under visible light irradiation. This proposal is at the forefront of a number of important fields, and therefore the outcomes are expected to be of great interest to a broad spectrum of industry sectors, including sustainable energy supply, solar energy applications, and environmental purification. This novel material system could lead to highly efficient photocatalysts for application in solar energy to split water to produce hydrogen. The outcomes of this project will position Australian researchers among the pioneering groups in this area and will benefit several major technology-related fields including sustainable energy supply, environmental protection engineering, and materials manufacture technology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560751
Funder
Australian Research Council
Funding Amount
$432,474.00
Summary
Facility for the Analysis of Biomacromolecular Interactions. A facility for the analysis of biological macromolecules and their interactions with ligand molecules is required to support a large number of research projects in high priority areas including mechanisms of aging, drug development and bio/nanotechnology at three different universities. The instrumentation will (i) afford quantitative measurements of binding affinities between biological and chemical macromolecules, which are available ....Facility for the Analysis of Biomacromolecular Interactions. A facility for the analysis of biological macromolecules and their interactions with ligand molecules is required to support a large number of research projects in high priority areas including mechanisms of aging, drug development and bio/nanotechnology at three different universities. The instrumentation will (i) afford quantitative measurements of binding affinities between biological and chemical macromolecules, which are available only in small quantities, and small, drug related molecules (by microcalorimetry and dual polarization interferometry), and (ii) provide equipment necessary for sample characterization and purification prior to quantitative measurements (CD spectroscopy, and FPLC equipment).Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238094
Funder
Australian Research Council
Funding Amount
$197,000.00
Summary
Fine and Ultrafine Particle - Characterisation and Research Facility. The proposed grant aims to establish an integrated facility for characterising and researching fine and ultrafine particles. It will serve various research groups of three collaborating universities. Current facilities are limited to characterisation of liquid-borne particles down to 10 nm size. To extend the groups research interests into aerosols and nanoparticles the facilities requested in this grant are essential. Equipme ....Fine and Ultrafine Particle - Characterisation and Research Facility. The proposed grant aims to establish an integrated facility for characterising and researching fine and ultrafine particles. It will serve various research groups of three collaborating universities. Current facilities are limited to characterisation of liquid-borne particles down to 10 nm size. To extend the groups research interests into aerosols and nanoparticles the facilities requested in this grant are essential. Equipment critical for research into catalytic processes is also requested. Integration of the groups will create a force that institutions and industries,nation-wide, can turn to when the need for competent analytical and research solutions for particles and catalysis arises.Read moreRead less