Mathematical Decision Support to Optimise Hospital Capacity and Utilisation. Hospital planners and executives regularly contend with challenging capacity related decisions. Decisions relating to prioritisation, allocation and sharing of resources have a profound impact on productivity, efficiency and patient outcomes. There is a lack of data-driven or quantitative decision support to make well-informed capacity related decisions of a strategic or tactical nature in a single hospital, or across a ....Mathematical Decision Support to Optimise Hospital Capacity and Utilisation. Hospital planners and executives regularly contend with challenging capacity related decisions. Decisions relating to prioritisation, allocation and sharing of resources have a profound impact on productivity, efficiency and patient outcomes. There is a lack of data-driven or quantitative decision support to make well-informed capacity related decisions of a strategic or tactical nature in a single hospital, or across a regional healthcare system. This project aims to deliver decision support for holistic hospital capacity assessment and planning optimisation. This will yield significant benefits for the health sector, providing a tool to optimise the allocation of resources and provision of infrastructure for regional hospital services.Read moreRead less
Real-time scheduling of trains to control peak electricity demand. This project aims to develop new scheduling and control methods that will enable railways to reduce their demand for electricity during peak demand periods, without undue disruption to the timetable.
These new methods and systems will integrate with—and expand the capabilities of—an Australian train control system that is used by railways around the world. This will enable better management of electricity within a region and be ....Real-time scheduling of trains to control peak electricity demand. This project aims to develop new scheduling and control methods that will enable railways to reduce their demand for electricity during peak demand periods, without undue disruption to the timetable.
These new methods and systems will integrate with—and expand the capabilities of—an Australian train control system that is used by railways around the world. This will enable better management of electricity within a region and better use of renewable energy sources, with significant cost savings for railways and the wider community.Read moreRead less
Determining features that separate groups of protein sequences. This project aims to develop mathematical approaches for determining features that distinguish one group of proteins from another, based on their amino acid sequences. The groups of sequences will reflect different outcomes, so that identifying the fundamental features can result in targeted interventions against the poorer outcome. A simple comparison at each position or of known features can fail to determine robust differentiator ....Determining features that separate groups of protein sequences. This project aims to develop mathematical approaches for determining features that distinguish one group of proteins from another, based on their amino acid sequences. The groups of sequences will reflect different outcomes, so that identifying the fundamental features can result in targeted interventions against the poorer outcome. A simple comparison at each position or of known features can fail to determine robust differentiators and so more complex methods are required. The project will, for example, help identify HIV vaccine targets by comparing early HIV transmission sequences from those in chronic infection. The methods will be applicable to viral proteins where high mutation rates make this task even more complex.Read moreRead less
New mathematics for multi-extremal optimization and diffusion tensor imaging. This project aims to establish numerically certifiable mathematical theory and methods for semi-algebraic optimisation problems. Numerically certifiable optimisation principles and techniques are vital for the practical use of optimisation technologies because they can be readily implemented by common computer models and algorithms. Yet no such methodologies exist for multi-extremal, semi-algebraic optimisation problem ....New mathematics for multi-extremal optimization and diffusion tensor imaging. This project aims to establish numerically certifiable mathematical theory and methods for semi-algebraic optimisation problems. Numerically certifiable optimisation principles and techniques are vital for the practical use of optimisation technologies because they can be readily implemented by common computer models and algorithms. Yet no such methodologies exist for multi-extremal, semi-algebraic optimisation problems which are common in modern science and medicine. The expected outcomes of this project include enhanced optimisation methods for diffusion tensor imaging, an emerging technology in brain sciences.Read moreRead less
Microcantilevers for multifrequency atomic force microscopy. This project aims to design a microcantilever with high-performing sensors more sensitive and with better noise performance than the typical optical system used in commercial Atomic Force Microscopes (AFMs). The AFM, a nanotechnology instrument, uses a microcantilever (with an extremely shape probe) to interrogate a sample surface. It has made important discoveries in nanotechnology, life sciences, nanomachining, material science and d ....Microcantilevers for multifrequency atomic force microscopy. This project aims to design a microcantilever with high-performing sensors more sensitive and with better noise performance than the typical optical system used in commercial Atomic Force Microscopes (AFMs). The AFM, a nanotechnology instrument, uses a microcantilever (with an extremely shape probe) to interrogate a sample surface. It has made important discoveries in nanotechnology, life sciences, nanomachining, material science and data storage systems. Despite its success, the technique’s spatial resolution and quantitative measurements are limited. This project could lead to breakthrough technologies such as atomic force spectroscopy to study elastic modulus of nanostructures, and establish Australia's prominence in this emerging field.Read moreRead less
TSuNAMi: Time Series Network Animal Modelling. Our proposal is motivated by and based upon the successful representation of time series as a network (or graph). We construct an abstract representation of a system from measurements of its changing behaviour over time. Properties of that structure (the network) then allow us to infer diagnostic information of the system. Specifically, we propose to apply this to livestock welfare during transport. By measuring the biological and environment condi ....TSuNAMi: Time Series Network Animal Modelling. Our proposal is motivated by and based upon the successful representation of time series as a network (or graph). We construct an abstract representation of a system from measurements of its changing behaviour over time. Properties of that structure (the network) then allow us to infer diagnostic information of the system. Specifically, we propose to apply this to livestock welfare during transport. By measuring the biological and environment condition of the animal we construct a network representation of that system. Geometric features of that network can then be used to infer health or duress of the subject. This proposal will develop the generic mathematical machinery to connect geometric features of the network with system behaviour. Read moreRead less
What predictions can I trust? Stability of chaotic random dynamical systems. This project aims to make significant progress on the intricate question of global stability of non-autonomous chaotic dynamical systems. Using ergodic theory, this project expects to determine when and how errors in dynamical models that are small and frequent, or large and infrequent, can cause dramatic changes in meaningful mathematical model outputs. Expected outcomes include the discovery of mathematical mechanisms ....What predictions can I trust? Stability of chaotic random dynamical systems. This project aims to make significant progress on the intricate question of global stability of non-autonomous chaotic dynamical systems. Using ergodic theory, this project expects to determine when and how errors in dynamical models that are small and frequent, or large and infrequent, can cause dramatic changes in meaningful mathematical model outputs. Expected outcomes include the discovery of mathematical mechanisms underlying large-scale (in)stability for time-dependent dynamical systems, and reliable numerical methods for detecting instabilities. This research is expected to lead to improved characterisations of shocks or collapse in externally driven dynamical systems and assist scientists to gauge which predictions they can trust.Read moreRead less
Modern mathematics to unravel the birth of coherence in dynamical systems. This project aims to reveal the precise mathematical mechanisms underlying the emergence and disappearance of long-lived coherent features in dynamical systems. This project expects to generate new fundamental mathematics in the area of dynamical systems, using innovative operator-theoretic approaches to carefully tease apart the lifecycles of coherent structures. The expected outcomes of this project include new mathemat ....Modern mathematics to unravel the birth of coherence in dynamical systems. This project aims to reveal the precise mathematical mechanisms underlying the emergence and disappearance of long-lived coherent features in dynamical systems. This project expects to generate new fundamental mathematics in the area of dynamical systems, using innovative operator-theoretic approaches to carefully tease apart the lifecycles of coherent structures. The expected outcomes of this project include new mathematical theory and computational algorithms to anticipate the genesis and destruction of coherent objects, which are key organisers of complex geophysical flows. This breakthrough mathematics should provide significant benefits, such as improved prediction of eddy transport and persistence of weather and climate patterns.Read moreRead less
Mathematical modelling of information flow in social networks. This proposal aims to develop new mathematical and statistical methods to understand information flow in social networks. By using novel information theoretic techniques, it will create new methods to characterise social information flow in social networks. These tools will allow derivation of fundamental limits of predictability for AI methods applied to digital data. New mathematics of information flow will produce insights into so ....Mathematical modelling of information flow in social networks. This proposal aims to develop new mathematical and statistical methods to understand information flow in social networks. By using novel information theoretic techniques, it will create new methods to characterise social information flow in social networks. These tools will allow derivation of fundamental limits of predictability for AI methods applied to digital data. New mathematics of information flow will produce insights into social influence in online social networks. Benefits include: better understanding of how echo chambers may form in social networks, predictive models for how misinformation can spread online such as during an emergency, and a framework for intercomparison of AI methods applied to digital data on individuals. Read moreRead less
Cooperative control of networked systems with constraints. This project aims to address the challenge of networked systems in deploying teams of robotic agents. Control of the networked system is extremely difficult due to real world constraints imposed on each agent. This project will focus on motion constraints, equipment/capability constraints, and spatial constraints. In addition to theoretical advances, the wider scientific community will benefit directly, because the control algorithms dev ....Cooperative control of networked systems with constraints. This project aims to address the challenge of networked systems in deploying teams of robotic agents. Control of the networked system is extremely difficult due to real world constraints imposed on each agent. This project will focus on motion constraints, equipment/capability constraints, and spatial constraints. In addition to theoretical advances, the wider scientific community will benefit directly, because the control algorithms developed are expected to allow straightforward deployment of robotic teams. There are myriad applications for cooperative robotic agents, ranging from surveillance, to environmental monitoring using underwater and aerial drone formations – with an array of benefits and impacts including economic, commercial and societal. The results are intended to ensure and cement Australia’s front-line position in the current technological revolution known as “Industry 4.0”.Read moreRead less