Heteronuclear parallel imaging and spectroscopy for magnetic resonance. This project will develop novel imaging technology for improved interrogation of biological processes in living tissue. Successful outcomes of this project are expected to contribute significantly to biomedical research efforts, such as improved early detection and treatment of cancer and chronic disease.
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less
Development of improved technologies for high throughput screening of potential disease susceptibility genes. This research is aimed at developing more efficient strategies to identify genes involved in common, human disorders. We aim to develop cost-effective, high throughput approaches for DNA extraction and preparation, accurately determining DNA concentration and quality and for undertaking extensive polymorphism genotyping and analysis. The suitability of equipment, analysis packages and so ....Development of improved technologies for high throughput screening of potential disease susceptibility genes. This research is aimed at developing more efficient strategies to identify genes involved in common, human disorders. We aim to develop cost-effective, high throughput approaches for DNA extraction and preparation, accurately determining DNA concentration and quality and for undertaking extensive polymorphism genotyping and analysis. The suitability of equipment, analysis packages and software, will be assessed and better technologies and packages developed. The study involves collaboration between a research centre with considerable expertise in molecular genetics and Corbett Research, a leader in the field of molecular equipment production. The development of better gene screening technologies has both molecular and commercial significance.Read moreRead less
Estimating The Risk of Preterm Birth Using Blood Tests. This research falls under National Research Priority 'A Healthy Start to Life'. The overall aim of this project is to develop risk estimates for preterm birth that may be used in clinical practice for the management of pregnancy. The project is concerned with developing computational methods, software, and a clinical interface that may be used by obstetricians. As well as identifying women at high risk of preterm birth, this approach will a ....Estimating The Risk of Preterm Birth Using Blood Tests. This research falls under National Research Priority 'A Healthy Start to Life'. The overall aim of this project is to develop risk estimates for preterm birth that may be used in clinical practice for the management of pregnancy. The project is concerned with developing computational methods, software, and a clinical interface that may be used by obstetricians. As well as identifying women at high risk of preterm birth, this approach will also help identify women at very low risk of preterm birth, and so those women more suited to management by midwives, either in a hospital or home birth setting.Read moreRead less
Intelligent training (iTraining) for the human Achilles tendon. The project aims to improve understanding of the mechanical environment of the Achilles tendon. The Achilles tendon plays a crucial role in human motor function and is also a structure that is commonly injured and notoriously difficult to treat. A major barrier to improving Achilles tendon function, preventing tendon injury and enhancing tendon repair is a poor understanding of the mechanical environment of the Achilles tendon durin ....Intelligent training (iTraining) for the human Achilles tendon. The project aims to improve understanding of the mechanical environment of the Achilles tendon. The Achilles tendon plays a crucial role in human motor function and is also a structure that is commonly injured and notoriously difficult to treat. A major barrier to improving Achilles tendon function, preventing tendon injury and enhancing tendon repair is a poor understanding of the mechanical environment of the Achilles tendon during training and rehabilitation. The project aims to develop a better understanding of the loading conditions that optimise tendon metabolism. Based on this, it then intends to develop new technologies to estimate the mechanical behaviour of the human Achilles tendon in real time based on integrated use of wearable technology, and new training guidelines that will optimise human tendon adaptation.Read moreRead less
Antimicrobial contact lens cases. Contamination of contact lens cases is now recognised as a major risk factor driving the incidence of corneal infections during contact lens wear. This project will develop novel antimicrobial materials for manufacture of lens cases for the prevention of infections associated with contact lens wear.
Optimising vascularisation of tissue engineering chambers for construction of robust tissues. We have produced a device that has commercial application in several fields of basic science, biotechnology and bioengineering. When its full potential is achieved, our innovative organ chamber will strengthen Australia's standing in the biotechnology field and enrich specific applications. The knowledge gained from understanding the growth of blood vessels will benefit several fields including chemical ....Optimising vascularisation of tissue engineering chambers for construction of robust tissues. We have produced a device that has commercial application in several fields of basic science, biotechnology and bioengineering. When its full potential is achieved, our innovative organ chamber will strengthen Australia's standing in the biotechnology field and enrich specific applications. The knowledge gained from understanding the growth of blood vessels will benefit several fields including chemical bioengineering, tissue engineering and repair, polymer chemistry, therapeutics in many areas (like cancer, heart disease, diabetes), hormone manufacture for agricultural, veterinary and medical purposes and cosmetics manufacture. The project will train several post-doctoral fellows and PhD students in this cutting edge field of researchRead moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453623
Funder
Australian Research Council
Funding Amount
$164,640.00
Summary
Peripheral quantitative computed tomography facility for analysing bone material and structural properties. We aim to establish a facility that allows non-invasive measurement of apparent material and structural properties of small animal and human bone using leading-edge technology, peripheral quantitative computed tomography (pQCT). pQCT measurements, incorporated into our fundamental bone research will improve our understanding of the role of mechanical, environmental and local factors in re ....Peripheral quantitative computed tomography facility for analysing bone material and structural properties. We aim to establish a facility that allows non-invasive measurement of apparent material and structural properties of small animal and human bone using leading-edge technology, peripheral quantitative computed tomography (pQCT). pQCT measurements, incorporated into our fundamental bone research will improve our understanding of the role of mechanical, environmental and local factors in regulating bone and mineral metabolism and altering bone properties. This has implications for maximising bone strength and promoting optimal health throughout life. The facility will be used for a diverse range of multidisciplinary basic bone research and is vital in order to maintain international competitiveness in the field.Read moreRead less
Adding a health dimension to integrated automation solutions for intelligent homes. We present a vision for the implementation of intelligent health care technology in the home of the future, focusing on areas of research that have the highest potential payoff over the next ten years for the community, the government and our industry partners. By "intelligent health care technology" we mean smart devices and systems that are aware of their context and can therefore assimilate information to supp ....Adding a health dimension to integrated automation solutions for intelligent homes. We present a vision for the implementation of intelligent health care technology in the home of the future, focusing on areas of research that have the highest potential payoff over the next ten years for the community, the government and our industry partners. By "intelligent health care technology" we mean smart devices and systems that are aware of their context and can therefore assimilate information to support care decisions. We aim to integrate these systems into existing home automation systems designed and marketed by our industrial collaborators. Outcomes will be underpinned by new knowledge acquisition and knowledge based decision systems.Read moreRead less
A comprehensive framework for interactive home telehealth research. We propose the development of a comprehensive research framework for the next generation of home telecare technology. The framework will support the unattended recording of patient physiological data and allow for patient management and information review by health professionals. It will include knowledge management tools to support clinical decision making. Research will also be conducted into the development of mobile communit ....A comprehensive framework for interactive home telehealth research. We propose the development of a comprehensive research framework for the next generation of home telecare technology. The framework will support the unattended recording of patient physiological data and allow for patient management and information review by health professionals. It will include knowledge management tools to support clinical decision making. Research will also be conducted into the development of mobile community networks and ambulatory monitoring technologies based around Bluetooth piconets.
The long-term outcomes of this research will be improved patient health outcomes in the chronically ill and a decreased overall health care expenditure by reducing hospital admissions.Read moreRead less