Improving Outcomes From Hepatitis B Infection In Aboriginal And Torres Strait Islander People In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Hepatitis B infection is common in Indigenous Australians causing serious problems such as liver failure and liver cancer. In the NT, there is an unusual and aggressive type. This project will establish if this unique strain does cause more liver failure and liver cancer. I will develop a special urine test to enable checking for liver cancer, and assess whether the use of the "Hep B Story" App will help people to have a better understanding of hepatitis B.
Role Of TNF-á In Growth, Lineage Commitment And Differentiation Of Liver Progenitor Cells
Funder
National Health and Medical Research Council
Funding Amount
$228,589.00
Summary
The infection rate of HBV is 20% in Chinese and 10% in Australian in particularly aboriginal. The end-point of this disease is development liver failure and need functional replacement of the liver. Cell therapy represents an alternative of liver transplantation owing to shortage of organ. The information derived from this study is essential for developing strategies to promote growth and differentiation of liver progenitor cell both in vivo and in vitro for therapies to treat liver diseases.
Epidemiology And Prevention Of Viral Hepatitis-related Hepatocellular Carcinoma
Funder
National Health and Medical Research Council
Funding Amount
$532,507.00
Summary
Liver cancer (HCC) is a serious global issue with high mortality. Viral hepatitis is a major risk and HCC can be prevented by early detection and treatment of hepatitis B infection. The PROLIFICA study aims to identify risks for HCC in West Africa, evaluate prevention strategies and develop simple diagnostic tests to help with HCC management in resource-poor settings. This important research will be directly translatable for HCC prevention in Australia and the Asia-Pacific region.
Population-level Epidemiological Trends In Hepatocellular Carcinoma In Queensland 1996 - 2010.
Funder
National Health and Medical Research Council
Funding Amount
$251,695.00
Summary
Incidence and mortality of hepatocellular carcinoma (HCC, the most common form of liver cancer) is increasing in Australia, driven by viral hepatitis infections. Disease burden is not defined in Queensland, particularly for Indigenous, migrant and regional and remote communities. Such factors may influence risk of viral hepatitis, access to treatment, and incidence and survival of HCC. Defining disease burdens will enable clinical programs targeted at groups most at risk in order to impact HCC t ....Incidence and mortality of hepatocellular carcinoma (HCC, the most common form of liver cancer) is increasing in Australia, driven by viral hepatitis infections. Disease burden is not defined in Queensland, particularly for Indigenous, migrant and regional and remote communities. Such factors may influence risk of viral hepatitis, access to treatment, and incidence and survival of HCC. Defining disease burdens will enable clinical programs targeted at groups most at risk in order to impact HCC trends.Read moreRead less
Modelling The Evolution Of Hepatitis C Virus By Integrating Large Sequence- And Immunological-databases.
Funder
National Health and Medical Research Council
Funding Amount
$289,980.00
Summary
Two hundred million people are infected with the Hepatitis C virus. There is no vaccine and the rate at which new strains of the virus arise enable it to evade the human immune system. This study aims to decipher how new viral strains are generated and transmitted, thereby enabling the development of new vaccines.
Injecting Drug Use, Incarceration, Infection: Investigating Opportunities For Public Health Interventions In Disadvantaged Populations
Funder
National Health and Medical Research Council
Funding Amount
$329,564.00
Summary
New knowledge required to address infectious diseases and mental illness among two disadvantaged and overlapping groups -people who inject drugs (PWID) and prisoners – will be produced: Cross sectional and longitudinal studies will examine HIV risk in specific populations; A system to track the emergence of injecting will be developed; The global scale of mental illness and TB among PWID will be determined; and how to improve coverage and delivery of TB prevention and treatment will be explored.