Personalised Medicine Markers Of Anti-EGFR Antibody Therapy In Metastatic Colorectal Cancer: Accelerating Clinical Translation With Collaborative Meta-analyses Based On Individual-participant Data
Funder
National Health and Medical Research Council
Funding Amount
$300,953.00
Summary
When selecting cancer therapy we take into account ‘biomarkers’, biological cancer characteristics that predict treatment success. We will work with an international group, the Advanced Colorectal Cancer Database, to analyse individual patient clinical trial data. We intend to validate biomarkers used to select treatment with cetuximab or panitumumab. Cancer genes called KRAS, NRAS, PTEN, PIK3CA, EREG and BRAF will be examined. Our study will provide best evidence for personalised treatment.
Targeting Sphingosine Kinase 1 To Sensitise Acute Myeloid Leukaemia To BH3 Mimetic Therapy
Funder
National Health and Medical Research Council
Funding Amount
$670,005.00
Summary
Acute Myeloid Leukaemia (AML) patients are currently treated with chemotherapeutics and despite their success at achieving disease remission these responses are often short lived, resulting in relapse and death. We have identified sphingosine kinase 1 as a new drug target in AML. This proposal aims to examine the role of targeting sphingosine kinase 1 in combination with new targeted therapies in patient samples and preclinical mouse models of AML.
A Major Upgrade of the Pierre Auger Cosmic Ray Observatory. A major upgrade is under-way to enhance the sensitivity of the 3000 square kilometre Pierre Auger Observatory in its search for the origin of the highest energy cosmic rays, the most energetic particles known in the Universe. This follows an unexpected Auger result that indicates a significant fraction of these cosmic rays are heavy nuclei. This project, assisting the upgrade, is expected to significantly improve the observatory's abil ....A Major Upgrade of the Pierre Auger Cosmic Ray Observatory. A major upgrade is under-way to enhance the sensitivity of the 3000 square kilometre Pierre Auger Observatory in its search for the origin of the highest energy cosmic rays, the most energetic particles known in the Universe. This follows an unexpected Auger result that indicates a significant fraction of these cosmic rays are heavy nuclei. This project, assisting the upgrade, is expected to significantly improve the observatory's ability to identify the mass, and hence the electric charge, of the incoming cosmic rays, allowing astrophysical source directions to be identified for the low charge particles less affected by cosmic magnetic fields. The project will also contribute to the understanding of particle interactions at energies well beyond those explored at the Large Hadron Collider.Read moreRead less
Exploring the high energy sky with the Pierre Auger Observatory. Cosmic rays are enormously energetic particles that must originate in the most violent environments in the Universe. This work will use the 3000 sq km Pierre Auger Observatory, built in collaboration with Australian physicists, to pinpoint the origin of these rare particles, thus laying to rest one of the longest standing mysteries in astronomy.
Unlocking the universe's high energy secrets with large scale neutrino detectors at the South Pole. Some of the most violent objects in the universe produce extremely energetic radiation in the form of particles, gamma-rays and neutrinos. Innovative observatories like IceCube, a cubic kilometre of instrumented ice at the South Pole, are being used to identify these astrophysical sources and the mechanisms that produce this extreme radiation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100170
Funder
Australian Research Council
Funding Amount
$159,450.00
Summary
Contribution to the AugerPrime upgrade of the Pierre Auger observatory. This project will support basic research into the properties of the highest energy particles in our Universe by contributing to the upgrade of the 3000 square kilometre Pierre Auger Observatory. A major detector upgrade (AugerPrime) is underway to enhance the sensitivity of the observatory for these high-energy cosmic rays. This follows an unexpected Auger result that indicates a significant fraction of these cosmic rays con ....Contribution to the AugerPrime upgrade of the Pierre Auger observatory. This project will support basic research into the properties of the highest energy particles in our Universe by contributing to the upgrade of the 3000 square kilometre Pierre Auger Observatory. A major detector upgrade (AugerPrime) is underway to enhance the sensitivity of the observatory for these high-energy cosmic rays. This follows an unexpected Auger result that indicates a significant fraction of these cosmic rays consist of heavy nuclei. AugerPrime will significantly improve the observatory's ability to identify the mass, and hence the charge, of the particles, allowing astrophysical source directions to be identified for the low charge particles which are less deflected by cosmic magnetic fields. The upgrade will also improve the understanding of particle physics at energies well beyond those explored at the Large Hadron Collider.Read moreRead less
A multi-messenger approach to understanding the high-energy Universe. Some of the most violent objects in the Universe produce extremely energetic radiation in the form of particles, gamma-rays and neutrinos. Innovative observatories like IceCube, a cubic kilometre of instrumented ice at the South Pole, are being used to identify these astrophysical sources and the mechanisms that produce this extreme radiation.
I am a molecular geneticist with a main research focus in the identification and characterisation of genes and molecular pathways involved in intellectual disability and epilepsy.
Building Central Asia: Linking the Growth of Asia to its Exhumation. The consumption of the Tethys Ocean and the associated collision of Gondwana-derived terranes with Eurasia resulted in the uplift of the highest mountain belt on Earth: the Himalayas. However, stresses from this collision zone propagated far into the Eurasian interior by reactivating faults and creating mountain belts along these fault zones. This project aims to map and model how and when fault (re)activation occurred by integ ....Building Central Asia: Linking the Growth of Asia to its Exhumation. The consumption of the Tethys Ocean and the associated collision of Gondwana-derived terranes with Eurasia resulted in the uplift of the highest mountain belt on Earth: the Himalayas. However, stresses from this collision zone propagated far into the Eurasian interior by reactivating faults and creating mountain belts along these fault zones. This project aims to map and model how and when fault (re)activation occurred by integrating multi-method thermochronological and structural data on major Meso-Cenozoic Central Asian fault systems. The resulting time-integrated tectonic model will aid in the understanding of the India-Eurasia collision, the building of the mountainous Central Asian landscape and its influence on the Asian climate.Read moreRead less
Cell type-specific transgene expression to increase Fe content in cereal grains. The grains industry forms a vital part of the Australian economy and farm sector. Increased iron concentrations of wheat and other cereal grains would greatly increase their nutritional value for people worldwide, thereby increasing their market value and profitability for farmers. High iron wheat would also lower the production costs of many Australian wheat products by reducing or eliminating the need for iron for ....Cell type-specific transgene expression to increase Fe content in cereal grains. The grains industry forms a vital part of the Australian economy and farm sector. Increased iron concentrations of wheat and other cereal grains would greatly increase their nutritional value for people worldwide, thereby increasing their market value and profitability for farmers. High iron wheat would also lower the production costs of many Australian wheat products by reducing or eliminating the need for iron fortification of wheat flour. High iron cereals promote healthy development of young Australians and can improve preventative healthcare by reducing the incidence of iron deficiency anaemia and biochemical deficiency.Read moreRead less