Personalised Medicine Markers Of Anti-EGFR Antibody Therapy In Metastatic Colorectal Cancer: Accelerating Clinical Translation With Collaborative Meta-analyses Based On Individual-participant Data
Funder
National Health and Medical Research Council
Funding Amount
$300,953.00
Summary
When selecting cancer therapy we take into account ‘biomarkers’, biological cancer characteristics that predict treatment success. We will work with an international group, the Advanced Colorectal Cancer Database, to analyse individual patient clinical trial data. We intend to validate biomarkers used to select treatment with cetuximab or panitumumab. Cancer genes called KRAS, NRAS, PTEN, PIK3CA, EREG and BRAF will be examined. Our study will provide best evidence for personalised treatment.
Targeting Sphingosine Kinase 1 To Sensitise Acute Myeloid Leukaemia To BH3 Mimetic Therapy
Funder
National Health and Medical Research Council
Funding Amount
$670,005.00
Summary
Acute Myeloid Leukaemia (AML) patients are currently treated with chemotherapeutics and despite their success at achieving disease remission these responses are often short lived, resulting in relapse and death. We have identified sphingosine kinase 1 as a new drug target in AML. This proposal aims to examine the role of targeting sphingosine kinase 1 in combination with new targeted therapies in patient samples and preclinical mouse models of AML.
A Major Upgrade of the Pierre Auger Cosmic Ray Observatory. A major upgrade is under-way to enhance the sensitivity of the 3000 square kilometre Pierre Auger Observatory in its search for the origin of the highest energy cosmic rays, the most energetic particles known in the Universe. This follows an unexpected Auger result that indicates a significant fraction of these cosmic rays are heavy nuclei. This project, assisting the upgrade, is expected to significantly improve the observatory's abil ....A Major Upgrade of the Pierre Auger Cosmic Ray Observatory. A major upgrade is under-way to enhance the sensitivity of the 3000 square kilometre Pierre Auger Observatory in its search for the origin of the highest energy cosmic rays, the most energetic particles known in the Universe. This follows an unexpected Auger result that indicates a significant fraction of these cosmic rays are heavy nuclei. This project, assisting the upgrade, is expected to significantly improve the observatory's ability to identify the mass, and hence the electric charge, of the incoming cosmic rays, allowing astrophysical source directions to be identified for the low charge particles less affected by cosmic magnetic fields. The project will also contribute to the understanding of particle interactions at energies well beyond those explored at the Large Hadron Collider.Read moreRead less
Exploring the high energy sky with the Pierre Auger Observatory. Cosmic rays are enormously energetic particles that must originate in the most violent environments in the Universe. This work will use the 3000 sq km Pierre Auger Observatory, built in collaboration with Australian physicists, to pinpoint the origin of these rare particles, thus laying to rest one of the longest standing mysteries in astronomy.
The Dawn of Extreme Gamma Ray Astronomy. This project aims to reveal the highest energy cosmic-ray particles in our galaxy, produced in extreme and still unknown astrophysical processes. Their interaction with nuclei in space produces the highest energy gamma ray light. Our project will make use of this extreme gamma ray light with upgraded and next-generation gamma-ray telescope arrays. With accompanying data from Australian radio telescopes, and computer models of the cosmic ray interactions, ....The Dawn of Extreme Gamma Ray Astronomy. This project aims to reveal the highest energy cosmic-ray particles in our galaxy, produced in extreme and still unknown astrophysical processes. Their interaction with nuclei in space produces the highest energy gamma ray light. Our project will make use of this extreme gamma ray light with upgraded and next-generation gamma-ray telescope arrays. With accompanying data from Australian radio telescopes, and computer models of the cosmic ray interactions, our project can finally determine from where these cosmic rays originate, yielding insight into our galaxy's evolution. Complex machine learning methods will be needed in a project that provides a world-leading student training ground, motivated by a century old mystery in astronomy.Read moreRead less
Exploring the High Energy Universe with Neutrinos detected in IceCube. The project aims to use the high energy neutrinos observed by the IceCube detector at the South Pole to uncover
the nature of the most energetic objects in the Universe. This project expects to find out what distant objects made
the neutrinos, understand their distribution through the Universe, and see if they are also cosmic and gamma ray
acceleration and production sites. Expected outcomes of this project include solving th ....Exploring the High Energy Universe with Neutrinos detected in IceCube. The project aims to use the high energy neutrinos observed by the IceCube detector at the South Pole to uncover
the nature of the most energetic objects in the Universe. This project expects to find out what distant objects made
the neutrinos, understand their distribution through the Universe, and see if they are also cosmic and gamma ray
acceleration and production sites. Expected outcomes of this project include solving this long-standing mystery in
high-energy astrophysics, development of new data analysis techniques, training new scientists, and educating
the public. These should provide significant benefits to science and society, through a better educated and critical
thinking workforce and public, ready to face future challenges.Read moreRead less
Unlocking the universe's high energy secrets with large scale neutrino detectors at the South Pole. Some of the most violent objects in the universe produce extremely energetic radiation in the form of particles, gamma-rays and neutrinos. Innovative observatories like IceCube, a cubic kilometre of instrumented ice at the South Pole, are being used to identify these astrophysical sources and the mechanisms that produce this extreme radiation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100170
Funder
Australian Research Council
Funding Amount
$159,450.00
Summary
Contribution to the AugerPrime upgrade of the Pierre Auger observatory. This project will support basic research into the properties of the highest energy particles in our Universe by contributing to the upgrade of the 3000 square kilometre Pierre Auger Observatory. A major detector upgrade (AugerPrime) is underway to enhance the sensitivity of the observatory for these high-energy cosmic rays. This follows an unexpected Auger result that indicates a significant fraction of these cosmic rays con ....Contribution to the AugerPrime upgrade of the Pierre Auger observatory. This project will support basic research into the properties of the highest energy particles in our Universe by contributing to the upgrade of the 3000 square kilometre Pierre Auger Observatory. A major detector upgrade (AugerPrime) is underway to enhance the sensitivity of the observatory for these high-energy cosmic rays. This follows an unexpected Auger result that indicates a significant fraction of these cosmic rays consist of heavy nuclei. AugerPrime will significantly improve the observatory's ability to identify the mass, and hence the charge, of the particles, allowing astrophysical source directions to be identified for the low charge particles which are less deflected by cosmic magnetic fields. The upgrade will also improve the understanding of particle physics at energies well beyond those explored at the Large Hadron Collider.Read moreRead less
A multi-messenger approach to understanding the high-energy Universe. Some of the most violent objects in the Universe produce extremely energetic radiation in the form of particles, gamma-rays and neutrinos. Innovative observatories like IceCube, a cubic kilometre of instrumented ice at the South Pole, are being used to identify these astrophysical sources and the mechanisms that produce this extreme radiation.