Whole Body Vibration For Osteoporosis: Shaking Up Our Treatment Options
Funder
National Health and Medical Research Council
Funding Amount
$961,017.00
Summary
Our aim is to examine the ability of vibration alone and in combination with osteoporosis drugs to reduce hip fracture in postmenopausal women. In Australia, 1 in 2 women >60yrs, will sustain an osteoporotic fracture. Only drugs notably decrease fracture; however none are entirely effective and some patients don’t respond. Whole body vibration has emerged as a potentially effective therapy. A combination of vibration and drugs may enhance the effects of both and revolutionise treatment.
Discovery Early Career Researcher Award - Grant ID: DE160100755
Funder
Australian Research Council
Funding Amount
$371,000.00
Summary
Evolution of genome architecture. The project aims to understand how changes to genome architecture over evolutionary time are linked to the diversity of animal morphology. Our genome sequence is arranged into higher order structures that enable coordinated gene expression. The appropriate expression of genes in time and space is necessary to produce the multitude of cell types that make up a multicellular organism. Yet, to date, genome topology is poorly explored, especially between species. Th ....Evolution of genome architecture. The project aims to understand how changes to genome architecture over evolutionary time are linked to the diversity of animal morphology. Our genome sequence is arranged into higher order structures that enable coordinated gene expression. The appropriate expression of genes in time and space is necessary to produce the multitude of cell types that make up a multicellular organism. Yet, to date, genome topology is poorly explored, especially between species. The project involves comparisons of the 3D structure of genomes in divergent species. These findings are expected to inform the underlying principles of gene regulation in animals and species evolution.Read moreRead less
Robust Productivity Measurement: An Econometric Distance Function Approach. Accurate measures of productivity are required in a range of economic analyses. For example, in the assessment of the success of microeconomic reforms, or in price-cap regulation of utility and transport infrastructure firms. In this project we investigate the use of econometric distance functions as a means of obtaining improved productivity measures. This new approach addresses the main criticisms of alternative ap ....Robust Productivity Measurement: An Econometric Distance Function Approach. Accurate measures of productivity are required in a range of economic analyses. For example, in the assessment of the success of microeconomic reforms, or in price-cap regulation of utility and transport infrastructure firms. In this project we investigate the use of econometric distance functions as a means of obtaining improved productivity measures. This new approach addresses the main criticisms of alternative approaches, such as the single output restriction in the production function approach, the optimisation assumptions embedded in both the value dual approach and the Törnqvist index approach, and the statistical noise criticism of the data envelopment analysis approach.Read moreRead less
Web Services Reputation Management. This project directly supports the National Research Priority 4: Safeguarding Australia. More specifically, it aims at creating mechanisms that will make it more difficult to use the Internet as a platform for launching attacks against the business processes of Australian organisations that provide and consume Web services. At the same time this will stimulate the establishment of high quality WS markets. As direct social benefit of this research, Australian o ....Web Services Reputation Management. This project directly supports the National Research Priority 4: Safeguarding Australia. More specifically, it aims at creating mechanisms that will make it more difficult to use the Internet as a platform for launching attacks against the business processes of Australian organisations that provide and consume Web services. At the same time this will stimulate the establishment of high quality WS markets. As direct social benefit of this research, Australian organisations will be able to integrate the best quality Web services as part of their business processes, and thereby avoid being negatively impacted by low quality and deceptive Web services. Read moreRead less
An international evaluation of work-family balance: Validation of the work-family balance measure and theoretical model. Work-family imbalance costs Australia $8 billion per annum, via staff absenteeism, turnover, and health costs. By employing two Australian and three international experts, this project will investigate the long-term process of work-family balance, identify effective employment policies, and produce a new balance measure for use by industry and government. This will lead to imp ....An international evaluation of work-family balance: Validation of the work-family balance measure and theoretical model. Work-family imbalance costs Australia $8 billion per annum, via staff absenteeism, turnover, and health costs. By employing two Australian and three international experts, this project will investigate the long-term process of work-family balance, identify effective employment policies, and produce a new balance measure for use by industry and government. This will lead to improved health, personal satisfaction and employment choices for working Australians, and hence higher productivity for industry. The research addresses the second national research priority: promoting and maintaining good health. The consequential contributions to knowledge will directly benefit Australia's regard within the global academic community.Read moreRead less
Signaling Pathways To Enhance Potency Of AMPK-targeting Drugs
Funder
National Health and Medical Research Council
Funding Amount
$661,966.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to epidemics of obesity-related metabolic diseases that place enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Our goal is to improve AMPK drug potency by identifying novel processes that sensitize AMPK to drugs.
Learned Academies Special Projects - Grant ID: LA170100011
Funder
Australian Research Council
Funding Amount
$170,000.00
Summary
The use of big data for social policy: benefits and risks. This project aims to investigate the benefits and risks of using ‘big data’ and analytics for social policy. Drawing on documentary sources and interviews with experts and stakeholders, the project will use five case studies to examine the capability, underlying assumptions and possible impacts of such techniques. The project will bring together a multi-disciplinary team of social and data scientists to identify the infrastructural, tech ....The use of big data for social policy: benefits and risks. This project aims to investigate the benefits and risks of using ‘big data’ and analytics for social policy. Drawing on documentary sources and interviews with experts and stakeholders, the project will use five case studies to examine the capability, underlying assumptions and possible impacts of such techniques. The project will bring together a multi-disciplinary team of social and data scientists to identify the infrastructural, technical, and social, ethical and legal issues that need to be addressed. The project will define key issues for future research, promote collaboration between the social sciences and big data disciplines, while creating opportunities for building capability for researchers in the social sciences. Read moreRead less
Recombination of mitochondrial genomes: what can we learn from chigger mites? This project will bring three benefits to Australia. First, it will enhance Australia's research capacity in the fields of organelle genomics and evolutionary biology. Second, it will yield highly skilled young researchers: a postdoctoral fellow (Shao), a PhD student and two BSc Honours students. Third, it will generate new knowledge about genome recombination in animal mitochondria. Recombination is a fundamental, yet ....Recombination of mitochondrial genomes: what can we learn from chigger mites? This project will bring three benefits to Australia. First, it will enhance Australia's research capacity in the fields of organelle genomics and evolutionary biology. Second, it will yield highly skilled young researchers: a postdoctoral fellow (Shao), a PhD student and two BSc Honours students. Third, it will generate new knowledge about genome recombination in animal mitochondria. Recombination is a fundamental, yet poorly understood issue in mitochondrial genomics and evolutionary biology. Knowledge from this project will also improve our understanding of other important issues that are associated with animal mitochondria; like the mechanisms of mitochondrial disease and ageing, and the evolution of modern humans and other animals.Read moreRead less
A molecular/morphological view of animal evolution based on marsupials. This project aims to provide high-accuracy methods of evolutionary inference extendable to nearly all other organisms. It aims to research the evolution of animal diversity and calibrate evolutionary timescales on a case study of marsupial mammals, and differentiate between internal and external factors that govern animals’ ability to adapt and diversify. The project will collate a large, open-source three-dimensional catalo ....A molecular/morphological view of animal evolution based on marsupials. This project aims to provide high-accuracy methods of evolutionary inference extendable to nearly all other organisms. It aims to research the evolution of animal diversity and calibrate evolutionary timescales on a case study of marsupial mammals, and differentiate between internal and external factors that govern animals’ ability to adapt and diversify. The project will collate a large, open-source three-dimensional catalogue of the evolving marsupial skeleton, which could provide a detailed and publicly accessible narrative of the evolutionary past and future adaptability of Australian marsupials. The proposed development of methods to quantify the effect of past and present biodiversity crises (e.g. environmental change) is expected to inform longer-term conservation planning.Read moreRead less
Antibiotic resistance is a looming public health crisis. New antibiotics with new mechanisms of action are desperately needed. The long-term goal of this research is to develop new drugs that disarm bacteria to overcome the problem of antibiotic resistance.