Sex preselection of stallion spermatozoa. This study will develop novel techniques that will maintain and optimise the fertility of sex-sorted stallion semen before and after processing through a flow cytometer. Ultimately, spermatozoa obtained from ejaculation or from the testes sperm storage site (epididymes) at the time of castration will be sorted into X- (female) or Y- (male) populations and used to inseminate mares and thus, enable horse breeders to predetermine the sex of their foal at th ....Sex preselection of stallion spermatozoa. This study will develop novel techniques that will maintain and optimise the fertility of sex-sorted stallion semen before and after processing through a flow cytometer. Ultimately, spermatozoa obtained from ejaculation or from the testes sperm storage site (epididymes) at the time of castration will be sorted into X- (female) or Y- (male) populations and used to inseminate mares and thus, enable horse breeders to predetermine the sex of their foal at the time of insemination. The introduction of sex-sorted semen into the Australian horse industry (worth some $6.2 billion) will ensure that Australia leads the world in equine reproductive technology.Read moreRead less
Marker assisted selection of honey bees. The project will develop new molecular markers for commercially relevant trait of honey bees and ways of using these to implement marker-assisted selection for honey bee genetic improvement. Beekeepers need to use genetically improved stock to remain competitive. Honey production needs to be improved, and new ways of identifying disease resistant bees are needed. Unfortunately, breeding bees is very difficult. This project will use modern molecular gen ....Marker assisted selection of honey bees. The project will develop new molecular markers for commercially relevant trait of honey bees and ways of using these to implement marker-assisted selection for honey bee genetic improvement. Beekeepers need to use genetically improved stock to remain competitive. Honey production needs to be improved, and new ways of identifying disease resistant bees are needed. Unfortunately, breeding bees is very difficult. This project will use modern molecular genetic techniques to help find new efficient ways to breed better bees. The benefits will be a more viable beekeeping sector, a keystone industry that provides pollination services essential to many horticultural industriesRead moreRead less
Improving diagnostic accuracy and treatment options for equine PPID. Equine Pituitary Pars Intermedia Dysfunction (PPID) is a common, chronic and potentially life-threatening disease of older horses and ponies. Although a treatment is available, the disease is poorly understood and there are some concerns that the current diagnostic technology is not delivering accurate results. Thus, this project aims to develop a more accurate diagnostic test for PPID, while exploring the relationship between ....Improving diagnostic accuracy and treatment options for equine PPID. Equine Pituitary Pars Intermedia Dysfunction (PPID) is a common, chronic and potentially life-threatening disease of older horses and ponies. Although a treatment is available, the disease is poorly understood and there are some concerns that the current diagnostic technology is not delivering accurate results. Thus, this project aims to develop a more accurate diagnostic test for PPID, while exploring the relationship between PPID and metabolic syndrome, to generate new insights into the cause and consequences of both diseases. As an added benefit, the project will assist horseracing laboratories to improve their detection methods for peptide doping in younger competition horses.
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Improving the Sustainability of Australian Livestock Production Systems. The sustainability of livestock production systems must urgently be improved. This Future Fellowship builds upon Dr Zamira Gibb's portfolio of high-impact research to deliver extension and adoption activities which will improve the outcomes of cattle and horse selective breeding programs; allowing the dissemination of low-methane genetics to remote Northern Australian cattle breeding regions, reducing wastage of breeding ho ....Improving the Sustainability of Australian Livestock Production Systems. The sustainability of livestock production systems must urgently be improved. This Future Fellowship builds upon Dr Zamira Gibb's portfolio of high-impact research to deliver extension and adoption activities which will improve the outcomes of cattle and horse selective breeding programs; allowing the dissemination of low-methane genetics to remote Northern Australian cattle breeding regions, reducing wastage of breeding horses and dairy cattle, and improving foal heath and offspring longevity. This project will address the environmental, ethical, and economic concerns which threaten the sustainability of these culturally significant livestock industries which are the cornerstone of everyday life in regional communities. Read moreRead less
Enhancing fertility for the Thoroughbred and Standardbred industries. Enhancing fertility for the Thoroughbred and Standardbred industries. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project aims to provide a platform for competitive collaborations between universities, biotechnology companies and horse breeders: the end-users of technological developments in equine reproduction. The Thoroughbred and Standardbred bree ....Enhancing fertility for the Thoroughbred and Standardbred industries. Enhancing fertility for the Thoroughbred and Standardbred industries. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project aims to provide a platform for competitive collaborations between universities, biotechnology companies and horse breeders: the end-users of technological developments in equine reproduction. The Thoroughbred and Standardbred breeding industries contribute over $6.5 billion per annum to the Australian economy and employ thousands of staff across their value chains. However, these industries suffer from breeding program inefficiencies that amount to over $800 million in annual losses. Expected outcomes are novel reproductive technologies and specialised research capabilities that will make the Australian equine industry a global leader.Read moreRead less
Enhancing the efficiency of equine reproduction: relevant to the Thoroughbred and Standardbred breeding industries. The purpose of this project is to link the equine breeding industry with a major centre of reproductive research at the University of Newcastle. By creating this unique nexus, major efficiency gains will be achieved for this industry that will not only secure its international competitiveness but also significantly enhance its profitability.
The genetics of social regulation of reproduction in honey bees. The aim is to characterise the genes that regulate worker reproduction in honeybees and to understand how the effects of these genes are regulated by the social environment. There is an inherent conflict between the interests of each worker (that can increase its biological fitness by laying eggs) and the collective workers (that are disadvantaged by their half sister's reproduction). How sterility is normally maintained in socia ....The genetics of social regulation of reproduction in honey bees. The aim is to characterise the genes that regulate worker reproduction in honeybees and to understand how the effects of these genes are regulated by the social environment. There is an inherent conflict between the interests of each worker (that can increase its biological fitness by laying eggs) and the collective workers (that are disadvantaged by their half sister's reproduction). How sterility is normally maintained in social insects remains an important unsolved mystery of biology. To solve this mystery we will use genomic techniques characterize the genes that control sterility and show how they are regulated by the social environment.Read moreRead less
A New Recombinant Subunit Vaccine against Equine Herpesviruses 1 and 4. Equine herpesviruses 1 and 4 (EHV-1 and EHV-4) cause respiratory disease, abortion and myeloencephalitis in horse populations worldwide. Despite extensive use of whole virus vaccines, these two viruses continue to circulate among Australian horses and are a continuing threat to brading, and to racing performance. The current vaccines are expensive and are marked in Australia by an overseas company. The project will assess th ....A New Recombinant Subunit Vaccine against Equine Herpesviruses 1 and 4. Equine herpesviruses 1 and 4 (EHV-1 and EHV-4) cause respiratory disease, abortion and myeloencephalitis in horse populations worldwide. Despite extensive use of whole virus vaccines, these two viruses continue to circulate among Australian horses and are a continuing threat to brading, and to racing performance. The current vaccines are expensive and are marked in Australia by an overseas company. The project will assess the ability of a new subunit vaccine produced by recombinant DNA technology to 1) provide horses with high levels of protective immune responses and 2) to prevent or limit EHV-1 and EHV-4 infection following experimental challenge.Read moreRead less
Equine rhinitis A virus; molecular pathogenesis and methods for control. The horse industry in Australia is primarily based in rural locations and is a major contributor to the national economy both in terms of direct economic contribution to gross domestic product and as a major employer of people in regional Australia. The research proposed in this project will improve our understanding of the pathogenesis of a virus that causes respiratory disease in horses that is related to the virus that c ....Equine rhinitis A virus; molecular pathogenesis and methods for control. The horse industry in Australia is primarily based in rural locations and is a major contributor to the national economy both in terms of direct economic contribution to gross domestic product and as a major employer of people in regional Australia. The research proposed in this project will improve our understanding of the pathogenesis of a virus that causes respiratory disease in horses that is related to the virus that causes foot and mouth disease in ruminants and swine. The technology developed during this project would have a global market.Read moreRead less
Proteomic approaches for the detection of administered peptide hormones, growth factors and related substances in the horse. This project will develop innovative techniques for the detection of new protein doping agents potentially used within the Australian horse racing industry.