Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
Coevolution of sundew bugs and sundews. This project aims to conduct a study of insect-plant interactions to determine if insects and plants coevolve or if they diversify by other evolutionary processes. Insect-plant coevolution is a hotly contested field in evolutionary biology. In Australia, a remarkable interaction exists between carnivorous plants and a group of bugs that steal the plant’s prey. This system offers a great opportunity to test competing coevolutionary theories through a combin ....Coevolution of sundew bugs and sundews. This project aims to conduct a study of insect-plant interactions to determine if insects and plants coevolve or if they diversify by other evolutionary processes. Insect-plant coevolution is a hotly contested field in evolutionary biology. In Australia, a remarkable interaction exists between carnivorous plants and a group of bugs that steal the plant’s prey. This system offers a great opportunity to test competing coevolutionary theories through a combination of historical and ecological approaches. The project expects to showcase the evolution and uniqueness of Australia’s native biota.Read moreRead less
Situational Assessment as a Marker of Cognitive Skill Decay. The aim of this study is to test how differences in exposure to complex tasks change the capacity for situational assessment. Amongst drivers, pilots and electricity controllers, the capacity to assess and respond effectively to changes in the operational environment are critical in sustaining performance and ensuring the safety and security of the public. Establishing the nature of this relationship will enable, for the first time, ob ....Situational Assessment as a Marker of Cognitive Skill Decay. The aim of this study is to test how differences in exposure to complex tasks change the capacity for situational assessment. Amongst drivers, pilots and electricity controllers, the capacity to assess and respond effectively to changes in the operational environment are critical in sustaining performance and ensuring the safety and security of the public. Establishing the nature of this relationship will enable, for the first time, objective measures of cognitive skill decay. In evaluating cognitive skill decay more accurately, we will provide a cost-effective, easily administered tool, enabling practitioners to identify and address areas of development and providing data to anticipate when cognitive skill decay is most likely to occur.Read moreRead less